Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

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Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Desarrollos recientes en el diseño de embarcaciones rápidas

During the last twenty years, Damen Shipyards, a multinational shipbuilding group with 6000 employees worldwide, has done extensive research on the development of hull designs for fast monohull vessels. In the 1990s the Enlarged Ship Concept was developed, leading to highly improved sea keeping capabilities and vessel behaviour in waves at high speed. This hull design concept was applied in the Damen SPa 4207 patrol vessel and has proven extremely successful, reducing vertical accelerations by 50% and, thus, allowing vessels to keep operating at high speed in waves. Over 25 units of the Damen SPa 4207 have been delivered so far. After the successful introduction of the Enlarged Ship Concept, Damen and Delft University continued developing the next generation hull form: the axebow design. Compared to the already good sea keeping capacities of the Enlarged Ship Concept, model tests indicated a further reduction of vertical accelerations. This was proven by real-time measurements on the first built axebow vessels in 2006 and 2007. In the last 3 years, over 30 axe bow supply vessels have been delivered to very satisfied operators. As a next step, Damen has applied the axe bow design to the latest patrol vessel design, the Damen SPa 5009. The first vessel of this design is currently under construction and its trials are scheduled by the end of 2011. The paper describes the background of the research done by Damen and Delft University, focusing on the mathematical and scientific aspects of the axebow design and its application on various ship types. The development and design of the latest Damen patrol vessel, SPa 5009, will be introduced, describing its seakeeping performance, operatability and crew ergonomics. Finally, the paper will mention the current and future research topics that Damen and Delft University are working on together, identifying the developments of the future generation patrol vessels.Durante los últimos 20 años, los astilleros Damen, un grupo multinacional constructor de buques con 6000 empleados alrededor del mundo, han investigado ampliamente sobre el desarrollo de los diseños de cascos para embarcaciones rápidas monocasco. Durante los 90, el Concepto del Buque Ampliado fue desarrollado, conllevando a capacidades mejoradas de navegabilidad y comportamiento de la embarcación en oleaje a alta velocidad. Este concepto de diseño de casco se aplicó en la embarcación de patrullaje Damen SPa 4207, y se ha comprobado extremadamente exitoso, reduciendo aceleraciones verticales por 50% y, así, permitiendo que las embarcaciones sigan operando a alta velocidad en oleaje. Más de 25 unidades del Damen SPa 4207 se han entregado hasta la fecha. Luego de la presentación exitosa del Concepto del Buque Ampliado, Damen y la Universidad Delft continuaron desarrollando la forma de casco de la siguiente generación: el diseño de proa en arco (axebow design). Comparado con las ya buenas capacidades de navegabilidad del Concepto del Buque Ampliado, pruebas del modelo indican adicional reducción de la aceleración vertical. Esto se comprobó mediante mediciones en tiempo real en las primeras embarcaciones construidas con proa en arco (axebow) en 2006 y 2007. En los últimos tres años, más de 30 buques de suministro de proa en arco se han entregado a operadores muy satisfechos. Como paso siguiente, Damen ha aplicado el diseño de proa en arco a su más reciente diseño de embarcación de patrullaje, el Damen SPa 5009. La primera embarcación de este diseño está actualmente bajo construcción y sus pruebas están programadas para fines de 2011. El documento describe los antecedentes de la investigación realizada por Damen y la Universidad Delft, enfocándose en los aspectos matemáticos y científicos del diseño de proa en arco y su aplicación en varios tipos de embarcaciones. El desarrollo y diseño de la más reciente embarcación de patrullaje, SPa 5009, se presentará, describiendo su desempeño de navegabilidad, operabilidad y ergonomía de tripulación. Finalmente, el documento mencionará los temas de investigación actuales y a future sobre los cuales Damen y la Universidad Delft están trabajando conjuntamente, identificando los desarrollos de las embarcaciones de patrullaje de futura generación

The position of reporting guidelines in qualitative nursing research

Editorial

Transparency in the reporting of nursing research

Editorial

Automated database-guided expert-supervised orientation for immunophenotypic diagnosis and classification of acute leukemia

Precise classification of acute leukemia (AL) is crucial for adequate treatment. EuroFlow has previously designed an AL orientation tube (ALOT) to guide towards the relevant classification panel (T-cell acute lymphoblastic leukemia (T-ALL), B-cell precursor (BCP)-ALL and/or acute myeloid leukemia (AML)) and final diagnosis. Now we built a reference database with 656 typical AL samples (145 T-ALL, 377 BCP-ALL, 134 AML), processed and analyzed via standardized protocols. Using principal component analysis (PCA)-based plots and automated classification algorithms for direct comparison of single-cells from individual patients against the database, another 783 cases were subsequently evaluated. Depending on the database-guided results, patients were categorized as: (i) typical T, B or Myeloid without or; (ii) with a transitional component to another lineage; (iii) atypical; or (iv) mixed-lineage. Using this automated algorithm, in 781/783 cases (99.7%) the right panel was selected, and data comparable to the final WHO-diagnosis was already provided in >93% of cases (85% T-ALL, 97% BCP-ALL, 95% AML and 87% mixed-phenotype AL patients), even without data on the full-characterization panels. Our results show that database-guided analysis facilitates standardized interpretation of ALOT results and allows accurate selection of the relevant classification panels, hence providing a solid basis for designing future WHO AL classifications

Outside the gate: sub-urban legal practices in early medieval England

Many aspects of English early medieval (Anglo-Saxon) legal landscapes can be discerned in archaeological and toponymic evidence, ranging from the locations of legislative councils and judicial assemblies to sites of capital punishment. Among the corpus of such sites a striking group can be detected at the periphery of urban spaces. Gates into a number of towns appear to have functioned as legislative meeting-places, and even gave their names to some legally constituted communities, while suburban locations also feature prominently as sites of gallows and public punishment. In this paper historical, archaeological and toponymic evidence is used to examine this phenomenon of suburban legal practices and to pose questions about the wider dimensions of the early medieval legal landscape

Recent Progress in the Use of Glucagon and Glucagon Receptor Antagonists in the Treatment of Diabetes Mellitus

Glucagon is an important pancreatic hormone, released into blood circulation by alpha cells of the islet of Langerhans. Glucagon induces gluconeogenesis and glycogenolysis in hepatocytes, leading to an increase in hepatic glucose production and subsequently hyperglycemia in susceptible individuals. Hyperglucagonemia is a constant feature in patients with T2DM. A number of bioactive agents that can block glucagon receptor have been identified. These glucagon receptor antagonists can reduce the hyperglycemia associated with exogenous glucagon administration in normal as well as diabetic subjects. Glucagon receptor antagonists include isoserine and beta-alanine derivatives, bicyclic 19-residue peptide BI-32169, Des-His1-[Glu9] glucagon amide and related compounds, 5-hydroxyalkyl-4-phenylpyridines, N-[3-cano-6- (1,1 dimethylpropyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]-2-ethylbutamide, Skyrin and NNC 250926. The absorption, dosage, catabolism, excretion and medicinal chemistry of these agents are the subject of this review. It emphasizes the role of glucagon in glucose homeostasis and how it could be applied as a novel tool for the management of diabetes mellitus by blocking its receptors with either monoclonal antibodies, peptide and non-peptide antagonists or gene knockout techniques

The experiences of people with liver disease of palliative and end-of-life care in the United Kingdom – a systematic literature review and metasynthesis

Background Liver disease is a growing health concern and a major cause of death. It causes multiple symptoms, including financial, psychological and social issues. To address these challenges, palliative care can support people alongside active treatment, and towards the end of life, but little is known about the care experiences of individuals with liver disease in the United Kingdom. This review aimed to explore the palliative and end-of-life care experiences of people with liver disease in the United Kingdom. Method A systematic review was conducted using a five-stage process and following Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines. Searches were across Web of Science, Scopus, EBSCO and grey literature until 10 May 2023. The review was registered through International Prospective Register of Systematic Reviews (PROSPERO). NVivo 12.5 was used to facilitate data analysis (systematic review registration: PROSPERO CRD42022382649). Results Of 6035 papers (excluding duplicates) found from searches, five met the inclusion criteria of primary research related to adults with liver disease receiving palliative and/or end-of-life care in the United Kingdom, published in English. Reflexive thematic analysis of the data was conducted. The themes identified were the experiences of people with liver disease of relating to healthcare professionals, using services, receiving support, and experiences of information and communication. These were connected by an overarching concept of disempowerment versus empowerment, with the notion of person-centred care as an important feature. Conclusion This review has found variations in the care experiences of people with advanced liver disease towards the end of life and an overall lack of access to specialist palliative care services. Where services are designed to be person-centred, experiences are more empowering. Further research is needed but with recognition that it is often unclear when care for people with liver disease is palliative or end-of-life. Patient and Public Contribution An online public involvement workshop was held on 18 April 2023 through Voice (2023). This included four people with liver disease and four carers to discuss the review findings and to design a qualitative research study to further explore the topic