The Hopf algebra structure of the Z3_3-graded quantum supergroup GLq,j(1∣1)_{q,j}(1|1)

In this work, we give some features of the Z$_3$-graded quantum supergroup

Multiband optical variability of 3C 279 on diverse time-scales

We have monitored the flat spectrum radio quasar, 3C 279, in the optical B, V, R, and I passbands from 2018 February to 2018 July for 24 nights, with a total of 716 frames, to study flux, colour, and spectral variability on diverse time-scales. 3C 279 was observed using seven different telescopes: two in India, two in Argentina, two in Bulgaria, and one in Turkey to understand the nature of the source in optical regime. The source was found to be active during the whole monitoring period and displayed significant flux variations in B, V, R, and I passbands. Variability amplitudes on intraday basis varied from 5.20 to 17.9 per cent. A close inspection of variability patterns during our observation cycle reveals simultaneity among optical emissions from all passbands. During the complete monitoring period, progressive increase in the amplitude of variability with frequency was detected for our target. The amplitudes of variability in B, V, R, and I passbands have been estimated to be 177 per cent, 172 per cent, 171 per cent, and 158 per cent, respectively. Using the structure function technique, we found intraday time-scales ranging from ∼23 min to about 115 min. We also studied colour–magnitude relationship and found indications of mild bluer-when-brighter trend on shorter time-scales. Spectral indices ranged from 2.3 to 3.0 with no clear trend on long-term basis. We have also generated spectral energy distributions for 3C 279 in optical B, V, R, and I passbands for 17 nights. Finally, possible emission mechanisms causing variability in blazars are discussed briefly.Fil: Agarwal, Aditi. Indian Institute of Astrophysics; IndiaFil: Cellone, Sergio Aldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Andruchow, Ileana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Mammana, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Complejo Astronómico "El Leoncito". Universidad Nacional de Córdoba. Complejo Astronómico "El Leoncito". Universidad Nacional de la Plata. Complejo Astronómico "El Leoncito". Universidad Nacional de San Juan. Complejo Astronómico "El Leoncito"; ArgentinaFil: Singh, Mridweeka. Aryabhatta Research Institute of Observational Sciences; IndiaFil: Anupama, G. C.. Indian Institute of Astrophysics; IndiaFil: Mihov, B.. Bulgarian Academy of Sciences; BulgariaFil: Raj, Ashish. Indian Institute of Astrophysics; IndiaFil: Slavcheva Mihova, L.. Bulgarian Academy of Sciences; BulgariaFil: Özdönmez, Aykut. Tübİtak National Observatory; TurquíaFil: Ege, Ergün. Istanbul University; Turquí

Vascular Wall-Resident CD44+ Multipotent Stem Cells Give Rise to Pericytes and Smooth Muscle Cells and Contribute to New Vessel Maturation

Here, we identify CD44(+)CD90(+)CD73(+)CD34(−)CD45(−) cells within the adult human arterial adventitia with properties of multipotency which were named vascular wall-resident multipotent stem cells (VW-MPSCs). VW-MPSCs exhibit typical mesenchymal stem cell characteristics including cell surface markers in immunostaining and flow cytometric analyses, and differentiation into adipocytes, chondrocytes and osteocytes under culture conditions. Particularly, TGFß1 stimulation up-regulates smooth muscle cell markers in VW-MPSCs. Using fluorescent cell labelling and co-localisation studies we show that VW-MPSCs differentiate to pericytes/smooth muscle cells which cover the wall of newly formed endothelial capillary-like structures in vitro. Co-implantation of EGFP-labelled VW-MPSCs and human umbilical vein endothelial cells into SCID mice subcutaneously via Matrigel results in new vessels formation which were covered by pericyte- or smooth muscle-like cells generated from implanted VW-MPSCs. Our results suggest that VW-MPSCs are of relevance for vascular morphogenesis, repair and self-renewal of vascular wall cells and for local capacity of neovascularization in disease processes

Paying for parking : improving stated-preference surveys

This article describes an experiment which introduced random ranges into the variables used for the design of a stated preference survey and its effects on willingness to pay for parking. User behaviour at the time of parking was modelled to determine their willingness to pay in order to get to their final destination more quickly. Calculating willingness to pay is fundamental during the social and economic assessment of projects. It is important to correctly model how car parks and their users interact in order to get values which represent reality as closely as possible. Willingness to pay is calculated using a stated preference survey and by calibrating multinomial logit models, taking variable tastes into account. It is shown that a value with a low variability can be obtained for willingness to pay by correctly establishing the context of the choice and randomly changing the variables around an average value

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis

Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized by intricate interplay of molecular interactions. Identification of targets for multifactorial diseases such as SBC, the most frequent complication of breast and prostate cancers, is a challenge. Towards achieving our aim of identification of targets specific to SBC, we constructed a 'Cancer Genes Network', a representative protein interactome of cancer genes. Using graph theoretical methods, we obtained a set of key genes that are relevant for generic mechanisms of cancers and have a role in biological essentiality. We also compiled a curated dataset of 391 SBC genes from published literature which serves as a basis of ontological correlates of secondary bone cancer. Building on these results, we implement a strategy based on generic cancer genes, SBC genes and gene ontology enrichment method, to obtain a set of targets that are specific to bone metastasis. Through this study, we present an approach for probing one of the major complications in cancers, namely, metastasis. The results on genes that play generic roles in cancer phenotype, obtained by network analysis of 'Cancer Genes Network', have broader implications in understanding the role of molecular regulators in mechanisms of cancers. Specifically, our study provides a set of potential targets that are of ontological and regulatory relevance to secondary bone cancer.Comment: 54 pages (19 pages main text; 11 Figures; 26 pages of supplementary information). Revised after critical reviews. Accepted for Publication in PLoS ON

Terahertz communications for 5G and beyond

A brief discussion about the exclusive properties and applications of terahertz technology is provided in this chapter. The frequency spectrum terahertz (THz) is also discussed. The applications of terahertz in the field of sensors and terahertz for communications are covered. State-of-the-art literature starting from the early to the latest research conducted is provided and analyzed in terms of the performance of terahertz systems. Terahertz, known as Tera waves or T-waves rather than submillimeter wave, has approximately a fraction of a wavelength less than 30 μm. T-wave is heavily used in sensing and imaging applications, and has no ionization hazards and is an excellent candidate frequency band to defeat the multipaths interference problems for pulse communications. The lower quantum energy of T-waves identifies its potential applications toward near-field imaging, telecommunications, spectroscopy, and sensing, including medical diagnoses and security screening. Identification of DNA signatures including complex real-time molecular dynamics through dielectric resonance is a good example of terahertz spectroscopy instruments nowadays. This concluding chapter will not only address the practical applications of terahertz communications, but also identify the research challenges that lie ahead in terms of terahertz antenna desig

Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli

Predictive understanding of cell signaling network operation based on general prior knowledge but consistent with empirical data in a specific environmental context is a current challenge in computational biology. Recent work has demonstrated that Boolean logic can be used to create context-specific network models by training proteomic pathway maps to dedicated biochemical data; however, the Boolean formalism is restricted to characterizing protein species as either fully active or inactive. To advance beyond this limitation, we propose a novel form of fuzzy logic sufficiently flexible to model quantitative data but also sufficiently simple to efficiently construct models by training pathway maps on dedicated experimental measurements. Our new approach, termed constrained fuzzy logic (cFL), converts a prior knowledge network (obtained from literature or interactome databases) into a computable model that describes graded values of protein activation across multiple pathways. We train a cFL-converted network to experimental data describing hepatocytic protein activation by inflammatory cytokines and demonstrate the application of the resultant trained models for three important purposes: (a) generating experimentally testable biological hypotheses concerning pathway crosstalk, (b) establishing capability for quantitative prediction of protein activity, and (c) prediction and understanding of the cytokine release phenotypic response. Our methodology systematically and quantitatively trains a protein pathway map summarizing curated literature to context-specific biochemical data. This process generates a computable model yielding successful prediction of new test data and offering biological insight into complex datasets that are difficult to fully analyze by intuition alone.National Institutes of Health (U.S.) (NIH grant P50-GM68762)National Institutes of Health (U.S.) (Grant U54-CA112967)United States. Dept. of Defense (Institute for Collaborative Biotechnologies

Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle

Background: Gene regulation by transcription factors (TF) is species, tissue and time specific. To better understand how the genetic code controls gene expression in bovine muscle we associated gene expression data from developing Longissimus thoracis et lumborum skeletal muscle with bovine promoter sequence information.Results: We created a highly conserved genome-wide promoter landscape comprising 87,408 interactions relating 333 TFs with their 9,242 predicted target genes (TGs). We discovered that the complete set of predicted TGs share an average of 2.75 predicted TF binding sites (TFBSs) and that the average co-expression between a TF and its predicted TGs is higher than the average co-expression between the same TF and all genes. Conversely, pairs of TFs sharing predicted TGs showed a co-expression correlation higher that pairs of TFs not sharing TGs. Finally, we exploited the co-occurrence of predicted TFBS in the context of muscle-derived functionally-coherent modules including cell cycle, mitochondria, immune system, fat metabolism, muscle/glycolysis, and ribosome. Our findings enabled us to reverse engineer a regulatory network of core processes, and correctly identified the involvement of E2F1, GATA2 and NFKB1 in the regulation of cell cycle, fat, and muscle/glycolysis, respectively.Conclusion: The pivotal implication of our research is two-fold: (1) there exists a robust genome-wide expression signal between TFs and their predicted TGs in cattle muscle consistent with the extent of promoter sharing; and (2) this signal can be exploited to recover the cellular mechanisms underpinning transcription regulation of muscle structure and development in bovine. Our study represents the first genome-wide report linking tissue specific co-expression to co-regulation in a non-model vertebrate

Contrast medium-induced nephropathy. Aspects on incidence, consequences, risk factors and prevention

Contrast media-induced nephropathy (CIN) is a well-known complication of radiological examinations employing iodine contrast media (I-CM). The rapid development and frequent use of coronary interventions and multi-channel detector computed tomography with concomitant administration of relatively large doses of I-CM has contributed to an increasing number of CIN cases during the last few years. Reduced renal function, especially when caused by diabetic nephropathy or renal arteriosclerosis, in combination with dehydration, congestive heart failure, hypotension, and administration of nephrotoxic drugs are risk factors for the development of CIN. When CM-based examinations cannot be replaced by other techniques in patients at risk of CIN, focus should be directed towards analysis of number and type of risk factors, adequate estimation of GFR, institution of proper preventive measures including hydration and post-procedural observation combined with surveillance of serum creatinine for 1-3 days. For the radiologist, there are several steps to consider in order to minimise the risk for CIN: use of “low-“ or “iso-osmolar” I-CM and dosing the I-CM in relation to GFR and body weight being the most important as well as utilizing radiographic techniques to keep the I-CM dose in gram iodine as low as possible below the numerical value of estimated GFR. There is as yet no pharmacological prevention that has been proven to be effective