1,068 research outputs found
Are There Age Spreads in Star Forming Regions?
A luminosity spread at a given effective temperature is ubiquitously seen in
the Hertzsprung-Russell (HR) diagrams of young star forming regions and often
interpreted in terms of a prolonged period (>=10 Myr) of star formation. I
review the evidence that the observed luminosity spreads are genuine and not
caused by astrophysical sources of scatter. I then address whether the
luminosity spreads necessarily imply large age spreads, by comparing HR diagram
ages with ages from independent clocks such as stellar rotation rate, the
presence of circumstellar material and lithium depletion. I argue that whilst
there probably is a true luminosity dispersion, there is little evidence to
support age spreads larger than a few Myr. This paradox could be resolved by
brief periods of rapid accretion during the class I pre main-sequence phase.Comment: To appear in the proceedings of JENAM10: Star Clusters in the Era of
Large Surveys, 8 page
Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration
The Gaia-ESO Survey: the most metal-poor stars in the Galactic bulge
We present the first results of the EMBLA survey (Extremely Metal-poor BuLge
stars with AAOmega), aimed at finding metal-poor stars in the Milky Way bulge,
where the oldest stars should now preferentially reside. EMBLA utilises
SkyMapper photometry to pre-select metal-poor candidates, which are
subsequently confirmed using AAOmega spectroscopy. We describe the discovery
and analysis of four bulge giants with -2.72<=[Fe/H]<=-2.48, the lowest
metallicity bulge stars studied with high-resolution spectroscopy to date.
Using FLAMES/UVES spectra through the Gaia-ESO Survey we have derived
abundances of twelve elements. Given the uncertainties, we find a chemical
similarity between these bulge stars and halo stars of the same metallicity,
although the abundance scatter may be larger, with some of the stars showing
unusual [{\alpha}/Fe] ratios.Comment: 7 pages, 5 figures. Accepted for publication by MNRA
Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis
Background: Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic secretion pathway (PSP) may enhance the risk for RP/CP in patients with CF.Methods: We enrolled: 48 patients affected by CF complicated by RP/CP and, as controls 35 patients with CF without pancreatitis and 80 unrelated healthy subjects. We tested a panel of 8 genes involved in the IPAT, i.e. PRSS1, PRSS2, SPINK1, CTRC, CASR, CFTR, CTSB and KRT8 and 23 additional genes implicated in the PSP.Results: We found 14/48 patients (29.2%) with mutations in genes involved in IPAT in the group of CF patients with RP/CP, while mutations in such genes were found in 2/35 (5.7%) patients with CF without pancreatitis and in 3/80 (3.8%) healthy subjects (p < 0.001). Thus, we found mutations in 12 genes of the PSP in 11/48 (22.9%) patients with CF and RP/CP. Overall, 19/48 (39.6%) patients with CF and RP/CP showed one or more mutations in the genes involved in the IPAT and in the PSP while such figure was 4/35 (11.4%) for patients with CF without pancreatitis and 11/80 (13.7%) for healthy controls (p < 0.001).Conclusions: The trans-heterozygous association between CFTR mutations in genes involved in the pathways of pancreatic enzyme activation and the pancreatic secretion may be risk factors for the development of recurrent or chronic pancreatitis in patients with CF
A precision measurement of direct CP violation in the decay of neutral kaons into two pions
The direct CP violation parameter Re(epsilon'/epsilon) has been measured from
the decay rates of neutral kaons into two pions using the NA48 detector at the
CERN SPS. The 2001 running period was devoted to collecting additional data
under varied conditions compared to earlier years (1997-99). The new data yield
the result: Re(epsilon'/epsilon) = (13.7 +/- 3.1) times 10^{-4}. Combining this
result with that published from the 1997, 98 and 99 data, an overall value of
Re(epsilon'/epsilon) = (14.7 +/- 2.2) times 10^{-4} is obtained from the NA48
experiment.Comment: 19 pages, 5 figures, to be published in Physics Letters
Measurement of the Ratio Gamma(KL -> pi+ pi-)/Gamma(KL -> pi e nu) and Extraction of the CP Violation Parameter |eta+-|
We present a measurement of the ratio of the decay rates Gamma(KL -> pi+
pi-)/Gamma(KL -> pi e nu), denoted as Gamma(K2pi)/Gamma(Ke3). The analysis is
based on data taken during a dedicated run in 1999 by the NA48 experiment at
the CERN SPS. Using a sample of 47000 K2pi and five million Ke3 decays, we find
Gamma(K2pi)/Gamma(Ke3) = (4.835 +- 0.022(stat) +- 0.016(syst)) x 10^-3. From
this we derive the branching ratio of the CP violating decay KL -> pi+ pi- and
the CP violation parameter |eta+-|. Excluding the CP conserving direct photon
emission component KL -> pi+ pi- gamma, we obtain the results BR(KL -> pi+ pi-)
= (1.941 +- 0.019) x 10^-3 and |eta+-| = (2.223 +- 0.012) x 10^-3.Comment: 20 pages, 7 figures, accepted by Phys. Lett.
First observation of the KS->pi0 gamma gamma decay
Using the NA48 detector at the CERN SPS, 31 KS->pi0 gamma gamma candidates
with an estimated background of 13.7 +- 3.2 events have been observed. This
first observation leads to a branching ratio of BR(KS->pi0 gamma gamma) = (4.9
+- 1.6(stat) +- 0.9(syst)) x 10^-8 in agreement with Chiral Perturbation theory
predictions.Comment: 10 pages, 4 figures submitted to Phys. Lett.
Search for CP violation in K0 -> 3 pi0 decays
Using data taken during the year 2000 with the NA48 detector at the CERN SPS,
a search for the CP violating decay K_S -> 3 pi0 has been performed. From a fit
to the lifetime distribution of about 4.9 million reconstructed K0/K0bar -> 3
pi0 decays, the CP violating amplitude eta_000 = A(K_S -> 3 pi0)/A(K_L -> 3
pi0) has been found to be Re(eta_000) = -0.002 +- 0.011 +- 0.015 and
Im(eta_000) = -0.003 +- 0.013 +- 0.017. This corresponds to an upper limit on
the branching fraction of Br(K_S -> 3 pi0) < 7.4 x 10^-7 at 90% confidence
level. The result is used to improve knowledge of Re(epsilon) and the CPT
violating quantity Im(delta) via the Bell-Steinberger relation.Comment: 18 pages, 7 figures, submitted to Phys. Lett.
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