ALMA Observations of the Young Substellar Binary System 2M1207

We present ALMA observations of the 2M1207 system, a young binary made of a brown dwarf with a planetary-mass companion at a projected separation of about 40 au. We detect emission from dust continuum at 0.89 mm and from the $J = 3 - 2$ rotational transition of CO from a very compact disk around the young brown dwarf. The small radius found for this brown dwarf disk may be due to truncation from the tidal interaction with the planetary-mass companion. Under the assumption of optically thin dust emission, we estimated a dust mass of 0.1 $M_{\oplus}$ for the 2M1207A disk, and a 3$\sigma$ upper limit of $\sim 1~M_{\rm{Moon}}$ for dust surrounding 2M1207b, which is the tightest upper limit obtained so far for the mass of dust particles surrounding a young planetary-mass companion. We discuss the impact of this and other non-detections of young planetary-mass companions for models of planet formation, which predict the presence of circum-planetary material surrounding these objects.Comment: 10 pages, 6 figures, accepted for publication in A

InternationaL cross-sectIonAl and longItudinal assessment on aSthma cONtrol in European adult patients : the LIAISON study protocol

The study is funded by Chiesi Farmaceutici S.p.A., Parma, ItalyPeer reviewedPublisher PD

Changes in the use of anti-asthmatic medication in an international cohort

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe aim of this study was to describe changes in pharmacotherapy for asthma since the early 1990s in an international cohort of young and middle-aged adults. A total of 28 centres from 14 countries participated in a longitudinal study. The study included 8,829 subjects with a mean follow-up time of 8.7 yrs. Change in the prevalence of use for medication was expressed as absolute net change (95% confidence interval) standardised to a 10-yr period. The use of anti-asthmatics was found to have increased by 3.1% (2.4-3.7%) and the prevalence of symptomatic asthma by 4.0% (3.5-4.5%). In the sample with asthma in both surveys (n=423), the use of inhaled corticosteroids increased by 12.2% (6.6-17.8%). Despite this, only 17.2% were using inhaled corticosteroids on a daily basis at follow-up. Females with continuous asthma were more likely, compared with males, and smokers with asthma, to have started using inhaled corticosteroids since the first survey. The use of anti-asthmatics has increased in a pattern consistent with current consensus on treatment. However, despite increased use of inhaled corticosteroids, a large majority of subjects with symptomatic asthma do not use this treatment on a daily basis, particularly males and smokers with asthma

The modified patient enablement instrument: a Portuguese cross-cultural adaptation, validity and reliability study

"Article number: 16087"Enabling patients with asthma to obtain the knowledge, confidence and skills they need in order to assume a major role in the management of their disease is cost effective. It should be an integral part of any plan for long-term control of asthma. The modified Patient Enablement Instrument (mPEI) is an easily administered questionnaire that was adapted in the United Kingdom to measure patient enablement in asthma, but its applicability in Portugal is not known. Validity and reliability of questionnaires should be tested before use in settings different from those of the original version. The purpose of this study was to test the applicability of the mPEI to Portuguese asthma patients after translation and cross-cultural adaptation, and to verify the structural validity, internal consistency and reproducibility of the instrument. The mPEI was translated to Portuguese and back translated to English. Its content validity was assessed by a debriefing interview with 10 asthma patients. The translated instrument was then administered to a random sample of 142 patients with persistent asthma. Structural validity and internal consistency were assessed. For reproducibility analysis, 86 patients completed the instrument again 7 days later. Item-scale correlations and exploratory factor analysis were used to assess structural validity. Cronbach's alpha was used to test internal consistency, and the intra-class correlation coefficient was used for the analysis of reproducibility. All items of the Portuguese version of the mPEI were found to be equivalent to the original English version. There were strong item-scale correlations that confirmed construct validity, with a one component structure and good internal consistency (Cronbach's alpha >0.8) as well as high test-retest reliability (ICC=0.85). The mPEI showed sound psychometric properties for the evaluation of enablement in patients with asthma making it a reliable instrument for use in research and clinical practice in Portugal. Further studies are needed to confirm its responsiveness.Financial support for this work was provided by FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and National Funds through FCT-Foundation for Science and Technology under the project POCI-01-0145-FEDER-007038, and by the project NORTE-01-0145-FEDER-000013, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).info:eu-repo/semantics/publishedVersio

Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population

Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20–44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991–1993; n56,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998–2000; n518,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007–2010; n510,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19–1.59) from 1998–2000 to 2007–2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhiniti

ALMA observations of the young substellar binary system 2M1207

Funding: J.M.C. acknowledges support from the National Aeronautics and Space Administration under Grant No. 15XRP15_20140 issued through the Exoplanets Research Program. Support for this work was provided by NASA through Hubble Fellowship grant HST-HF2-51369.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.We present ALMA observations of the 2M1207 system, a young binary made of a brown dwarf with a planetary-mass companion at a projected separation of about 40 au. We detect emission from dust continuum at 0.89 mm and from the J=3-2 rotational transition of CO from a very compact disk around the young brown dwarf. The small radius found for this brown dwarf disk may be due to truncation from the tidal interaction with the planetary-mass companion. Under the assumption of optically thin dust emission, we estimate a dust mass of 0.1 M ⊕ for the 2M1207A disk and a 3σ upper limit of ∼1 MMoon for dust surrounding 2M1207b, which is the tightest upper limit obtained so far for the mass of dust particles surrounding a young planetary-mass companion. We discuss the impact of this and other non-detections of young planetary-mass companions for models of planet formation that predict circumplanetary material to surround these objects.Publisher PDFPeer reviewe

Bright C2H emission in protoplanetary discs in Lupus: High volatile C/O > 1 ratios

Context. Recent ALMA surveys in different star-forming regions have shown that CO emission in protoplanetary discs is much fainter than expected. Accordingly, CO-based gas masses and gas to dust ratios are orders of magnitude lower than previously thought. This may be explained either as fast gas dispersal, or as chemical evolution and locking up of volatiles in larger bodies leading to the low observed CO fluxes. The latter processes lead to enhanced C/O ratios in the gas, which may be reflected in enhanced abundances of carbon-bearing molecules like C2H. Aims. The goal of this work is to use C2H observations to understand whether low CO fluxes are caused by volatile depletion or by fast gas dissipation. Methods. We present ALMA Cycle 4 C2H (N = 3-2, J = 7/ 2-5/ 2, F = 4-3 and F = 3-2) observations of a subsample of nine sources in the Lupus star-forming region. The integrated C2H emission is determined and compared to previous CO isotopologue observations and physical-chemical model predictions. Results. Seven out of nine discs are detected in C2H, whose line emission is almost as bright as 13CO. All detections are significantly brighter than the typical sensitivity of the observations, hinting at a bimodal distribution of the C2H line intensities. This conclusion is strengthened when our observations are compared with additional C2H observations of other discs. When compared with physical-chemical models, the observed C2H fluxes can be reproduced only if some level of volatile carbon and oxygen depletion is allowed and [C]/[O] > 1 in the gas. Models with reduced gas-to-dust ratios near unity however fail to reproduce the observed C2H line luminosity. A steeper than linear correlation between C2H and CN emission line is found for the Lupus discs. This is linked to the fact that C2H emission lines are affected more strongly by [C]/[O] variations than CN lines. Ring-like structures are detected both in C2H and in continuum emission but, as for CN, they do not seem to be connected. The source Sz 71 shows ring-shaped emission in both C2H and CN with the location of the peak intensity coinciding, within our 30 au resolution. Conclusions. Our new ALMA C2H observations favour volatile carbon and oxygen depletion rather than fast gas dispersal to explain the faint CO observations for most of the discs. This result has implications for disc-evolution and planet-formation theories, as disc gas masses may be larger than expected if CO is considered to be the main carbon carrier in the gas phase

Stringent limits on the magnetic field strength in the disc of TW Hya: ALMA observations of CN polarisation

Despite their importance in the star formation process, measurements of magnetic field strength in proto-planetary discs remain rare. While linear polarisation of dust and molecular lines can give insight into the magnetic field structure, only observations of the circular polarisation produced by Zeeman splitting provide a direct measurement of magnetic field strenghts. One of the most promising probes of magnetic field strengths is the paramagnetic radical CN. Here we present the first Atacama Large Millimeter/submillimeter Array (ALMA) observations of the Zeeman splitting of CN in the disc of TW Hya. The observations indicate an excellent polarisation performance of ALMA, but fail to detect significant polarisation. An analysis of eight individual CN hyperfine components as well as a stacking analysis of the strongest (non-blended) hyperfine components yields the most stringent limits obtained so far on the magnetic field strength in a proto-planetary disc. We find that the vertical component of the magnetic field |Bz|â

High gas-to-dust size ratio indicating efficient radial drift in the mm-faint CX Tauri disk

The large majority of protoplanetary disks have very compact continuum emission (≲ 15 AU) at millimeter wavelengths. However, high angular resolution observations that resolve these small disks are still lacking, due to their intrinsically fainter emission compared with large bright disks. In this Letter we present 1.3 mm ALMA data of the faint disk (∼10 mJy) orbiting the TTauri star CX Tau at a resolution of ∼40 mas, ∼5 AU in diameter. The millimeter dust disk is compact, with a 68% enclosing flux radius of 14 AU, and the intensity profile exhibits a sharp drop between 10 and 20 AU, and a shallow tail between 20 and 40 AU. No clear signatures of substructure in the dust continuum are observed, down to the same sensitivity level of the DSHARP large program. However, the angular resolution does not allow us to detect substructures on the scale of the disk aspect ratio in the inner regions. The radial intensity profile closely resembles the inner regions of more extended disks imaged at the same resolution in DSHARP, but with no rings present in the outer disk. No inner cavity is detected, even though the disk has been classified as a transition disk from the spectral energy distribution in the near-infrared. The emission of 12CO is much more extended, with a 68% enclosing flux radius of 75 AU. The large difference of the millimeter dust and gas extents (> 5) strongly points to radial drift, and closely matches the predictions of theoretical models