The compositional construction of Markov processes II

In an earlier paper we introduced a notion of Markov automaton, together with parallel operations which permit the compositional description of Markov processes. We illustrated by showing how to describe a system of n dining philosophers, and we observed that Perron-Frobenius theory yields a proof that the probability of reaching deadlock tends to one as the number of steps goes to infinity. In this paper we add sequential operations to the algebra (and the necessary structure to support them). The extra operations permit the description of hierarchical systems, and ones with evolving geometry

A Profile of Smoking and Health in Wales

No abstract available

Optimal hurricane overwash thickness for maximizing marsh resilience to sea level rise

The interplay between storms and sea level rise, and between ecology and sediment transport governs the behavior of rapidly evolving coastal ecosystems such as marshes and barrier islands. Sediment deposition during hurricanes is thought to increase the resilience of salt marshes to sea level rise by increasing soil elevation and vegetation productivity. We use mesocosms to simulate burial of Spartina alterniflora during hurricane-induced overwash events of various thickness (0-60 cm), and find that adventitious root growth within the overwash sediment layer increases total biomass by up to 120%. In contrast to most previous work illustrating a simple positive relationship between burial depth and vegetation productivity, our work reveals an optimum burial depth (510 cm) beyond which burial leads to plant mortality. The optimum burial depth increases with flooding frequency, indicating that storm deposition ameliorates flooding stress, and that its impact on productivity will become more important under accelerated sea level rise. Our results suggest that frequent, low magnitude storm events associated with naturally migrating islands may increase the resilience of marshes to sea level rise, and in turn, slow island migration rates. Synthesis: We find that burial deeper than the optimum results in reduced growth or mortality of marsh vegetation, which suggests that future increases in overwash thickness associated with more intense storms and artificial heightening of dunes could lead to less resilient marshes

MODELLING STOCK DYNAMICS IN THE SOUTHERN BENGUELA ECOSYSTEM FOR THE PERIOD 1978–2002

An ecosystem model of the southern Benguela was fitted to available time-series data for the period 1978–2002, to explore how changes in target fish populations in this ecosystem can be attributed to feeding interaction terms and population control patterns, the impact of fishing, and environmental forcing. Fishing patterns were estimated to explain only 2–3&#37 of the variability in the time-series, whereas an estimated productivity forcing pattern applied to phytoplankton explained 4–12&#37 of the variance represented by the sum of squares. Model settings describing prey vulnerability to their predators could explain around 40&#37 of the variability in the time-series. Modelled stock dynamics in the southern Benguela ecosystem more closely represent observed timeseries when wasp-waist control by small pelagic fish is simulated. Overall, model simulations suggest that almost half the variance in the time-series can be explained based on a combination of fishing, vulnerability settings and productivity patterns. Variation in mortalities and prey preferences over time, as well as model fits in relation to available effort series, are discussed. The study advances a model with improved parameterization and credibility to assist with an ecosystem approach to South African fisheries management. Afr. J. mar. Sci. 26: 179–19

Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia.

We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel adapted-dosing schedule (25 mg/kg on days +3 and +4) for Fanconi anemia (FA). With median follow-up of 3 years (range, 37 days to 6.2 years), all six patients engrafted. Two patients with multiple pre-transplant comorbidities died, one from sepsis and one from sepsis with associated chronic GVHD. Four patients without preexisting comorbidities and early transplant referrals are alive with 100% donor chimerism and excellent performance status. We conclude that adjusted-dosing post-transplant CY is effective in in vivo TCD to promote full donor engraftment in patients with FA

Massive Upland to Wetland Conversion Compensated for Historical Marsh Loss in Chesapeake Bay, USA

Sea level rise leads to coastal transgression, and the survival of ecosystems depends on their ability to migrate inland faster than they erode and submerge. We compared marsh extent between nineteenth-century maps and modern aerial photographs across the Chesapeake Bay, the largest estuary in North America, and found that Chesapeake marshes have maintained their spatial extent despite relative sea level rise rates that are among the fastest in the world. In the mapped region (i.e., 25% of modern Chesapeake Bay marshland),94 km2of marsh was lost primarily to shoreline erosion,whereas 101 km2of marsh was created by upland drowning.Simple projections over the entire Chesapeake region suggestthat approximately 100,000 acres (400 km2) of uplands have converted to wetlands and that about a third of all present-day marsh was created by drowning of upland ecosystems since the late nineteenth century. Marsh migration rates were weakly correlated with topographic slope and the amount of development of adjacent uplands, suggesting that additional processes may also be important. Nevertheless, our results emphasize that the location of coastal ecosystems changes rapidly on century timescales and that sea level rise does not necessarily lead to overall habitat loss

Peripheral volume measurements as indices of peripheral circulatory factors in the cardiovascular orthostatic response

Peripheral volume measurements as indices of circulatory factors in cardiovascular orthostatic respons