Extraction of the πNN\pi NN coupling constant from NN scattering data

We reexamine Chew's method for extracting the $\pi NN$ coupling constant from np differential cross section measurements. Values for this coupling are extracted below 350 MeV, in the potential model region, and up to 1 GeV. The analyses to 1~GeV have utilized 55 data sets. We compare these results to those obtained via $\chi^2$ mapping techniques. We find that these two methods give consistent results which are in agreement with previous Nijmegen determinations.Comment: 12 pages of text plus 2 figures. Revtex file and postscript figures available via anonymous FTP at ftp://clsaid.phys.vt.edu/pub/n

Indication of asymptotic scaling in the reactions dd→p3dd\to p^3H, dd→n3dd\to n^3He and dp→dpdp\to dp

It is shown that the differential cross sections of the reactions $dd\to ^3He n$ and $dd\to ^3H p$ measured at c.m.s.scattering angle$\theta_{cm}=60^\circ$ in the interval of the deuteron beam energy 0.5 - 1.2 GeV demonstrate the scaling behaviour,$d\sigma/d t\sim s^{-22}$, which follows from constituent quark counting rules. It is found also that the differential cross section of the elastic $dp\to dp$ scattering at $\theta_{cm}=125^\circ-135^\circ$ follows the scaling regime $\sim s^{-16}$ at beam energies 0.5 - 5 GeV. These data are parameterized here using the Reggeon exchange.Comment: 6 pages, Latex, 2 eps figures; final version accepted by Pis'ma v ZHETF, corrected and completed reference

Origin of light nuclei in near earth orbit

The possible sources of light nuclei populations observed recently below the geomagnetic cutoff by the AMS experiment are discussed in terms of nuclear processes: fragmentation of the incoming flux of cosmic helium on atmospheric nuclei, and nuclear coalescence from proton and helium induced reactions. Results of simulations for deuterium, tritium, helium 3 and 4, are presented.Comment: 11 pages, 4 figure

Angular momentum sharing in dissipative collisions

Light charged particles emitted by the projectile-like fragment were measured in the direct and reverse collision of $^{93}$Nb and $^{116}$Sn at 25 AMeV. The experimental multiplicities of Hydrogen and Helium particles as a function of the primary mass of the emitting fragment show evidence for a correlation with net mass transfer. The ratio of Hydrogen and Helium multiplicities points to a dependence of the angular momentum sharing on the net mass transfer.Comment: 8 pages, 2 figure

Determination of the pion-nucleon coupling constant and scattering lengths

We critically evaluate the isovector GMO sum rule for forward pion-nucleon scattering using the recent precision measurements of negatively charged pion-proton and pion-deuteron scattering lengths from pionic atoms. We deduce the charged-pion-nucleon coupling constant, with careful attention to systematic and statistical uncertainties. This determination gives, directly from data a pseudoscalar coupling constant of 14.11+-0.05(statistical)+-0.19(systematic) or a pseudovector one of 0.0783(11). This value is intermediate between that of indirect methods and the direct determination from backward neutron-proton differential scattering cross sections. We also use the pionic atom data to deduce the coherent symmetric and antisymmetric sums of the negatively charged pion-proton and pion-neutron scattering lengths with high precision. The symmetric sum gives 0.0012+-0.0002(statistical)+-0.0008 (systematic) and the antisymmetric one 0.0895+-0.0003(statistical)+-0.0013(systematic), both in units of inverse charged pion-mass. For the need of the present analysis, we improve the theoretical description of the pion-deuteron scattering length.Comment: 27 pages, 5 figures, submitted to Phys. Rev. C, few modifications and clarifications, no change in substance of the pape

Multifragmentation threshold in ^{93}Nb+{nat}Mg collisions at 30 MeV/nucleon

We analyzed the $^{93}Nb$ on $^{nat}Mg$ reaction at 30 MeV/nucleon in the aim of disentangling binary sequential decay and multifragmentation decay close to the energy threshold, i.e. $\simeq 3$ MeV/nucleon. Using the backtracing technique applied to the statistical models GEMINI and SMM we reconstruct simulated charge, mass and excitation energy distributions and compare them to the experimental ones. We show that data are better described by SMM than by GEMINI in agreement with the fact that multifragmentation is responsible for fragment production at excitation energies around 3 MeV/nucleon.Comment: 16 pages, 12 figures, 5 tables Soumis \`a Nuclear Physics

Quasi-Elastic Scattering in the Inclusive (3^3He, t) Reaction

The triton energy spectra of the charge-exchange $^{12}$C($^3$He,t) reaction at 2 GeV beam energy are analyzed in the quasi-elastic nucleon knock-out region. Considering that this region is mainly populated by the charge-exchange of a proton in $^3$He with a neutron in the target nucleus and the final proton going in the continuum, the cross-sections are written in the distorted-wave impulse approximation. The t-matrix for the elementary exchange process is constructed in the DWBA, using one pion- plus rho-exchange potential for the spin-isospin nucleon- nucleon potential. This t-matrix reproduces the experimental data on the elementary pn $\rightarrow$np process. The calculated cross-sections for the $^{12}$C($^3$He,t) reaction at $2^o$ to $7^o$ triton emission angle are compared with the corresponding experimental data, and are found in reasonable overall accord.Comment: 19 pages, latex, 11 postscript figures available at [email protected], submitted to Phy.Rev.

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

Multiple protein ubiquitination events at DNA double-strand breaks (DSBs) regulate damage recognition, signaling and repair. It has remained poorly understood how the repair process of DSBs is coordinated with the apoptotic response. Here, we identified the E4 ubiquitin ligase UFD-2 as a mediator of DNA-damage-induced apoptosis in a genetic screen in Caenorhabditis elegans. We found that, after initiation of homologous recombination by RAD-51, UFD-2 forms foci that contain substrate-processivity factors including the ubiquitin-selective segregase CDC-48 (p97), the deubiquitination enzyme ATX-3 (Ataxin-3) and the proteasome. In the absence of UFD-2, RAD-51 foci persist, and DNA damage-induced apoptosis is prevented. In contrast, UFD-2 foci are retained until recombination intermediates are removed by the Holliday-junction-processing enzymes GEN-1, MUS-81 or XPF-1. Formation of UFD-2 foci also requires proapoptotic CEP-1 (p53) signaling. Our findings establish a central role of UFD-2 in the coordination between the DNA-repair process and the apoptotic response

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century