Design, fabrication and testing of subscale propellant tanks with capillary traps Final report, 26 Jun. 1967 - 15 Mar. 1968

Hyrostatic stability characteristics of perforated plates and square-weave screens for fluid control during low-G operatio

Advanced propellant management system for spacecraft propulsion systems. Phase 1 - Survey study and evaluation

Apollo spacecraft propulsion system propellant managemen

Helical cationic antimicrobial peptide length and its impact on membrane disruption

AbstractCationic antimicrobial peptides (CAMPs) are important elements of innate immunity in higher organisms, representing an ancient defense mechanism against pathogenic bacteria. These peptides exhibit broad-spectrum antimicrobial activities, utilizing mechanisms that involve targeting bacterial membranes. Recently, a 34-residue CAMP (NA-CATH) was identified in cDNA from the venom gland of the Chinese cobra (Naja atra). A semi-conserved 11-residue pattern observed in the NA-CATH sequence provided the basis for generating an 11-residue truncated peptide, ATRA-1A, and its corresponding D-peptide isomer. While the antimicrobial and biophysical properties of the ATRA-1A stereoisomers have been investigated, their modes of action remain unclear. More broadly, mechanistic differences that can arise when investigating minimal antimicrobial units within larger naturally occurring CAMPs have not been rigorously explored. Therefore, the studies reported here are focused on this question and the interactions of full-length NA-CATH and the truncated ATRA-1A isomers with bacterial membranes. The results of these studies indicate that in engineering the ATRA-1A isomers, the associated change in peptide length and charge dramatically impacts not only their antimicrobial effectiveness, but also the mechanism of action they employ relative to that of the full-length parent peptide NA-CATH. These insights are relevant to future efforts to develop shorter versions of larger naturally occurring CAMPs for potential therapeutic applications

Feasibility and Informative Value of Environmental Sample Collection in the National Children\u27s Vanguard Study

Background: Birth cohort studies provide the opportunity to advance understanding of the impact of environmental factors on childhood health and development through prospective collection of environmental samples. Methods: We evaluated the feasibility and informative value of the environmental sample collection methodology in the initial pilot phase of the National Children\u27s Study, a planned U.S. environmental birth cohort study. Environmental samples were collected from January 2009–September 2010 at up to three home visits: pre-pregnancy (n¼306), pregnancy (n¼807), and 6-months postnatal (n¼117). Collections included air for particulate matter r2.5 mm (PM2.5), nitrogen dioxide, ozone, volatile organic compounds (VOCs), and carbonyls; vacuum dust for allergens/endotoxin; water for VOCs, trihalomethanes (THMs), and haloacetic acids (HAAs); and wipe samples for pesticides, semi-volatile organics, and metals. We characterized feasibility using sample collection rates and times and informative value using analyte detection frequencies (DF). Results: Among the 1230 home visits, environmental sample collection rates were high across all sample types (mean¼89%); all samples except the air PM2.5 samples had collection times o30 min. Informative value was low for water VOCs (median DF¼0%) and pesticide floor wipes (median DF¼5%). Informative value was moderate for air samples (median DF¼35%) and high for water THMs and HAAs (median DF¼91% and 75%, respectively). Conclusions: Though collection of environmental samples was feasible, some samples (e.g., wipe pesticides and water VOCs) yielded limited information. These results can be used in conjunction with other study design considerations, such as target population size and hypotheses of interest, to inform the method selection of future environmental health birth cohort studies

Pennsylvania Folklife Vol. 44, No. 1

• A Missing Link : The History of African Americans in Pennsylvania • The Twin City Elks Lodge: A Unifying Force in Farrell\u27s African American Community • The Greening of Philadelphia • The Saddlebag House Type and Pennsylvania Extendedhttps://digitalcommons.ursinus.edu/pafolklifemag/1141/thumbnail.jp

Characterization and prediction of permanent deformation properties of unbound granular materials for Pavement ME Design

The objective of this study is to characterize and predict the permanent deformation properties of unbound granular materials (UGMs) for Pavement ME Design. First, laboratory repeated load triaxial (RLT) tests are conducted on the UGMs from 11 quarries in Texas to measure the permanent strain curves. The shakedown theory is applied to evaluate the permanent deformation behavior of the selected UGMs. It is found that using Werkmeister's criteria to define the shakedown range boundaries is not suitable for the selected UGMs. Under this circumstance, new criteria are proposed to redefine the shakedown range boundaries for the flexible base materials in Texas. The new criteria are consistent with the current Texas flexible base specification in terms of aggregate classification. Second, the mechanistic-empirical design guide (MEPDG) model is used to determine the permanent deformation properties of the selected UGMs on the basis of the measured permanent strain curves. The determined permanent deformation properties are assigned as target values for the development of permanent deformation prediction models. Third, a series of performance-related base course properties are used to comprehensively characterize the UGMs, which include the dry density, moisture content, aggregate gradation, morphological properties, percent fines content, and methylene blue value. These performance-related base course properties are assigned as the inputs of the permanent deformation prediction models. Fourth, a multiple regression analysis is conducted to develop the prediction models for permanent deformation properties using these performance-related properties. The developed models are capable of accurately predicting the permanent deformation properties of UGMs. Compared to other prediction models (e.g., simple indicators-based models and Pavement ME Design models), the developed models have the highest prediction accuracy. It is also found that the Pavement ME model-predicted permanent strains are much lower than those measured from the RLT tests. This demonstrates that the current Pavement ME Design software substantially underestimates the rutting that occurs in base course. Finally, the developed prediction models are validated by comparing the predicted and measured permanent strains of other four base materials. The obtained R-squared value of 0.81 indicates that the developed models have a desirable accuracy in the prediction of permanent deformation properties of UGMs

The Two Variables in The Triple System HR 6469=V819 Her: One Eclipsing, One Spotted

A complete BV light curve, from 14 nights of good data obtained with the Vanderbilt University-Tennessee State University (VU-TSU) automatic telescope, are presented and solved with the Wilson-Devinney program. Third light is evaluated, with the companion star brighter by 0.58m in V and 0.11m in B. The eclipses are partial. Inferred color indices yield F2 V and F8 V for the eclipsing pair and G8 IV-III for the distant companion star. After removing the variability due to eclipses, we study the residual variability of the G8 IV-III star over the ten years 1982 to 1992. Each yearly light curve is fit with a two-spot model. Three relatively long-lived spots are identified, with rotation periods of 85.9d, 85.9d, and 86.1d. The weak and intermittent variability is understood because the G8 IV-III star has a Rossby number at the threshold for the onset of heavy spottedness

NUCLEAR MERCHANT SHIP REACTOR PROJECT. EXTENDED ZERO POWER TESTS NS SAVANNAH CORE I. Final Report

Experiments were performed on the NS Savannah Service Core I to supply irformation on future shipboard operation of the Nuclear Merchant Ship Reactor. Testing of instrumentation equipment was satisfactory. Correction factors for shipboard use were determined. Fast neutron flux, neutron fiux distribution, and stuck control rod studies were carried out successfully, as was a three- dimesional calculation to match two critical rod patterns. (auth

Site-specific prolapse surgery. I. Reliability and durability of native tissue paravaginal repair

Introduction and hypothesis: This study aims to compare native tissue abdominal and vaginal paravaginal repair, and to investigate whether surgical outcome was independent of operative route. Methods: Retrospective comparison of 111 displacement cysto-urethrocoeles, repaired between 1997 and 2007. Treatment was by surgeon assignment, 52 women having abdominal (APVR) and 59 vaginal paravaginal repairs. Main outcome measures were same-site prolapse recurrence, time to failure and surgical complications. Initial reliability was evaluated by chi-square test, 10-year durability by Kaplan-Meier survival analysis and Cox proportional hazards model. Results: When examined in the Cox proportional hazards model, anatomic results of APVR were more durable than a mechanically analogous transvaginal operation done [95% CI=1.029-2.708 (p value=0.038)]. Kaplan-Meier curves plateaued within 38 months. Symptom resolution was broadly equivalent. Surgical complication rate was 3.6%. Conclusions: Site-specific re-suture of torn native tissue has genuine curative potential. Most of the long-term success was attributable to site-specific repair, rather than nonspecific scar formation.9 page(s