Switching from subcutaneous to oral semaglutidein type 2 diabetes: A prospective study

Funding for open access charge: Universidad de Málaga / CBU

Stratifying diffuse large B-cell lymphoma patients treated with chemoimmunotherapy: GCB/non-GCB by immunohistochemistry is still a robust and feasible marker

Diffuse large B cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas that can be classified into three molecular subtypes by gene expression profiling (GEP): GCB, ABC and unclassified. Immunohistochemistry-based cell of origin (COO) classification, as a surrogate for GEP, using three available immunohistochemical algorithms was evaluated in TMA-arranged tissue samples from 297 patients with de novo DLBCL treated by chemoimmunotherapy (R-CHOP and R-CHOP-like regimens). Additionally, the prognostic impacts of MYC, BCL2, IRF4 and BCL6 abnormalities detected by FISH, the relationship between the immunohistochemical COO classification and the immunohistochemical expression of MYC, BCL2 and pSTAT3 proteins and clinical data were evaluated. In our series, non-GCB DLBCL patients had significantly worse progression-free survival (PFS) and overall survival (OS), as calculated using the Choi, Visco-Young and Hans algorithms, indicating that any of these algorithms would be appropriate for identifying patients who require alternative therapies to R-CHOP. Whilst MYC abnormalities had no impact on clinical outcome in the non-GCB subtype, those patients with isolated MYC rearrangements and a GCB-DLBCL phenotype had worse PFS and therefore might benefit from novel treatment approaches

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4+ T cell activation, and proliferation than do individuals recovered from COVID-19, with patent inverse correlations between humoral and cellular variables early post-vaccination. However, almost 8 months post-vaccination, SARS-CoV-2-specific responses are comparable between both groups. Our data indicate that a previous history of COVID-19 differentially determines the functional T and B cell-mediated responses to BNT162b2 vaccination over time.C.d.F., J.G.-P., and J.A. are supported by Instituto de Salud Carlos III (ISCII). We thank JM Ligos and Cytek Biosciences for their technical support. Research in E.L.-C.’s lab was supported by Fundación Familia Alonso, Santander Bank, Real Seguros, Fundación Mutua Madrileña, Fundación Uria, Fundación La Caixa, and Ayuntamiento de Madrid.S

Efectos del desajuste de un reflector ortoconjugado sobre los sensores de corriente de fibra óptica spun compensados

The influence of the maladjusted angle in a Faraday rotator mirror on a compensated optical fibre sensor made of spun high birefringence optical fibre for magnetooptic current sensing have been analysed and discussed

JAK/STAT blockade reverses the malignant phenotype of Hodgkin and Reed-Sternberg cells.

Constitutive activation of the JAK/STAT pathway is a common phenomenon in classic Hodgkin lymphoma (cHL). The clinical potential of anti-JAK/STAT therapy is being explored in early-stage clinical trials. Notwithstanding, very little information is available about the complex biological consequences of this blockade. Here, we investigated the effects of JAK/STAT pharmacological inhibition on cHL cell models using ruxolitinib, a JAK 1/2 inhibitor that induces apoptosis by concentration- and time-dependent mechanisms. An unbiased whole-transcriptome approach identified expression of the anti-GCSF receptor (CSF3R) as a potential surrogate biomarker of JAK/STAT overactivation. In addition, longitudinal gene expression analyses provided further mechanistic information about pertinent biological pathways involved, including 37 gene pathways distributed in 3 main clusters: cluster 1 was characterized by upregulation of the G2/M checkpoint and major histocompatibility complex-related clusters; 2 additional clusters (2 and 3) showed a progressive downregulation of the tumor-promoting inflammation signatures: JAK/STAT and interleukin 1 (IL-1)/IL-4/IL-13/IL-17. Together, our results confirm the therapeutic potential of JAK/STAT inhibitors in cHL, identify CSF3R as a new biomarker, and provide supporting genetic data and mechanistic understanding.The authors acknowledge the MD Anderson Biobank and the Spanish Biobank Network, supported by the ISCIII, for their invaluable help with tumor samples and TMAs. The authors also thank Javier Suela, from NIMGenetics, for his invaluable assistance with the gene expression analyses. This work was supported by the Instituto de Salud Carlos III (ISCIII) , cofunded by the European Regional Development Fund/European Social Fund (PI19/00083) , Ministerio de Economia, Industria y Competitividad (MINECO) (CIBERONC CB16/12/00291) , Direccion General de Universidade Investigacion Consejeria de Educacion e Investigacion de la Comunidad de Madrid (B2017/BMD-3778) , and a Roche Foundation Research Grant; V.M. is a recipient of an iPFIS predoctoral fellowship from ISCIII-AES-2020 (FI20/00184) .S

Insights into the co-assemblies formed by different aromatic short-peptide amphiphiles

This study was supported by project PID2020-118498GB-I00 funded by MCIN/AEI/10.13039/501100011033, Spain and by project CTQ2017-85658-R funded by MCIN/AEI/10.13039/501100011033/FEDER "Una manera de hacer Europa", Spain, and by FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain) project P18-FR-3533. CGV and MCMT acknowledge respectively grants FPU17/00491 and PRE2018083773 funded by MCIN/AEI/10.13039/501100011033 and FSE "El FSE invierte en tu futuro", Spain. Thanks go to the CIC personnel of the University of Granada for technical assistance. We thank the Centro de Servicios de Informatica y Redes de Comunicaciones (CSIRC), Universidad de Granada, for providing the computing time. The authors acknowledge Dr Rosario Herranz and Dr Francisco Fueyo-Gonzalez for the fluorophore 9-azetidinyl-5-butyl-quinolimide (AQui) used in this study, which was synthesized at Instituto de Quimica Medica-CSIC (IQM-CSIC) with the support of the Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion grant FU201567284-R.We have investigated the co-self-assembly, in water and at room temperature, of different aromatic short peptides containing Fmoc- (fluorenylmethyloxycarbonyl-) and Nap- (2-(naphthalen-2-yloxy)acetyl) groups having also different chirality. Using a combination of spectroscopy and microscopy techniques we have shown that mixtures of peptides have a stronger preference to form co-assemblies giving rise to different types of fibrils of well-defined morphology. Kinetic analysis of fluorescence resonance energy transfer (FRET) between Fmoc- and Nap- side groups reported more information about the process of self-assembly between different dipeptides. We have shown that when peptides are mixed in an equimolar ratio, the kinetics of co-aggregation is faster than that occurring when the proportion is unbalanced. Moreover, following the emission band of Nap-excimers we have shown that these peptides form co-assemblies in an alternate fashion at an equimolar ratio. The mechanism of self-assembly has been studied by molecular dynamics and monitored by differential scanning calorimetry. The mechanical properties of the resulting composite hydrogels have been evaluated by rheology. These results show that the formation of co-assemblies is promoted by π–π interactions between the different aromatic groups resulting in accelerating polymerization due to destabilization of the intermediates.MCIN/AEI, Spain PID2020-118498GB-I00 FPU17/00491MCIN/AEI/FEDER "Una manera de hacer Europa", Spain CTQ2017-85658-RFEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades (Spain) P18-FR-3533FSE "El FSE invierte en tu futuro", Spain PRE2018083773Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion gran

Fotografía en la colección de arte contemporáneo de la Universidad de Granada

La serie editorial de Cuadernos Técnicos del Patrimonio surge debido a la necesidad de dotar al Vicerrectorado de Extensión Universitaria de publicaciones que aborden aspectos patrimoniales en relación con cuestiones de carácter transversal y que sirvan de vehículo de difusión y diálogo de las distintas colecciones que conforman el rico acervo universitario. El objetivo es convertir estos Cuadernos en un espacio de reflexión y debate sobre temas relacionados con la conservación, la restauración, la gestión, la difusión y la puesta en valor de los bienes muebles e inmuebles de la Universidad de Granada en toda su amplitud. No se plantean con un enfoque exclusivamente local pues su intención es abrirse a distintas problemáticas patrimoniales y convertirse en un instrumento que integre estudios de carácter nacional e internacional. Asimismo, entendemos que al Patrimonio hay que afrontarlo desde una perspectiva histórica pero también actual y en diálogo con la compleja realidad social

Tu salud la cuidas tú, y nosotros te ayudamos

El trabajo obtuvo el primer premio de la modalidad B: 'Una escuela más cooperativa y equitativa', de los Premios Joaquín Sama 2007. Se recogen páginas web de interés sobre la temática del trabajoSe describen un conjunto de actividades desarrolladas en el IES Siberia Extremeña (Talarrubias, Badajoz) para concienciar a los alumnos y a la comunidad educativa sobre los efectos nocivos del tabaco, el alcohol y otras drogas.ExtremaduraConsejería de Educación. Dirección General de Política Educativa; Calle Delgado Valencia, 6; 06800 Mérida (Badajoz); Tel. +34924006714; Fax +34924006716; [email protected]