About Designing an Observer Pattern-Based Architecture for a Multi-objective Metaheuristic Optimization Framework

Multi-objective optimization with metaheuristics is an active and popular research field which is supported by the availability of software frameworks providing algorithms, benchmark problems, quality indicators and other related components. Most of these tools follow a monolithic architecture that frequently leads to a lack of flexibility when a user intends to add new features to the included algorithms. In this paper, we explore a different approach by designing a component-based architecture for a multi-objective optimization framework based on the observer pattern. In this architecture, most of the algorithmic components are observable entities that naturally allows to register a number of observers. This way, a metaheuristic is composed of a set of observable and observer elements, which can be easily extended without requiring to modify the algorithm. We have developed a prototype of this architecture and implemented the NSGA-II evolutionary algorithm on top of it as a case study. Our analysis confirms the improvement of flexibility using this architecture, pointing out the requirements it imposes and how performance is affected when adopting it.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Actividades preventivas en la mujer. Actualización PAPPS 2020

Se revisa la evidencia científica en las actividades preventivas de la atención de la mujer en relación con el seguimiento del embarazo, las actividades preventivas en la planificación y seguimiento de los métodos anticonceptivos, actividades preventivas en la menopausia, y la prevención de las fracturas osteoporóticas

Prevalencia de esofagitis eosinofílica: estudio multicéntrico en población pediátrica evaluada en 36 centros de gastroenterología de América Latina

Introducción y objetivo: La esofagitis eosinofílica es una enfermedad crónica, mediada inmunológicamente, descrita en series y publicaciones alrededor del mundo. En los últimos 20 años diversos estudios han intentado evaluar la incidencia y prevalencia de la enfermedad. El objetivo del presente trabajo es estimar la prevalencia de esofagitis eosinofílica en un grupo de niños atendidos en 36 centros de gastroenterología pediátrica de 10 países latinoamericanos. Materiales y métodos: A través de un protocolo multicéntrico, observacional y transversal se estimó la prevalencia de período de esofagitis eosinofílica entre los niños atendidos en consulta externa y sometidos a endoscopia superior diagnóstica por cualquier motivo en 36 centros de 10 países latinoamericanos durante un período de 3 meses. Resultados: Entre abril y junio de 2016 108 casos de esofagitis eosinofílica fueron evaluados. Asimismo, un promedio de 29,253 consultas ambulatorias y 4,152 endoscopias superiores de carácter diagnóstico fueron realizadas en los 36 centros participantes. La tasa de prevalencia de esofagitis eosinofílica en la población estudiada (n = 29,253) fue de 3,69 casos × 1,000 (IC 95%: 3.04 a 4.44) y entre los niños sometidos a endoscopia superior de rutina (n = 4,152) fue de 26 x 1,000 (IC 95%: 22.6 a 29.4). Conclusión: La tasa general de prevalencia de período de esofagitis eosinofílica en un grupo de niños evaluados en 36 centros latinoamericanos de gastroenterología pediátrica resultó de 3,69 × 1,000, y entre aquellos sometidos a endoscopia fue de 26 × 1,000. La prevalencia mostró una importante variabilidad entre los países y centros participantes. Este es el primer estudio de prevalencia de esofagitis eosinofílica pediátrica en Latinoamérica. Abstract: Introduction and objective: Eosinophilic esophagitis is a chronic, immune-mediated disease described in case series and publications worldwide. Over the past twenty years, the authors of different studies have attempted to evaluate its incidence and prevalence. The objetive of the present study was to estimate the prevalence of eosinophilic esophagitis in a group of children seen at 36 pediatric gastroenterology centers in ten Latin American countries. Materials and methods: A multicenter, observational, and cross-sectional study was conducted that estimated the period prevalence of eosinophilic esophagitis in children seen at outpatient consultation and that underwent diagnostic upper gastrointestinal endoscopy for any indication at 36 centers in 10 Latin American countries, within a 3-month time frame. Results: Between April and June 2016, 108 cases of eosinophilic esophagitis were evaluated. Likewise, an average of 29,253 outpatient consultations and 4,152 diagnostic upper gastrointestinal endoscopies were carried out at the 36 participating centers. The period prevalence of eosinophilic esophagitis in the population studied (n = 29,253) was 3.69 cases × 1,000 (95% CI: 3.04 to 4.44), and among the children that underwent routine upper gastrointestinal endoscopy (n = 4,152), it was 26 x 1,000 (95% CI: 22.6 to 29.4). Conclusions: The general period prevalence of eosinophilic esophagitis in a group of children evaluated at 36 Latin American pediatric gastroenterology centers was 3.69 × 1,000, and in the children that underwent endoscopy, it was 26 × 1,000. There was important prevalence variability between the participating countries and centers. The present analysis is the first study conducted on the prevalence of pediatric eosinophilic esophagitis in Latin America. Palabras clave: Esofagitis, Eosinofílica, Niños, Prevalencia, Latinoamérica, Keywords: Esophagitis, Eosinophilic, Children, Prevalence, Latin Americ

Infestación por Hirudo medicinalis (sanguijuela)

Las sanguijuelas son anélidos hermafroditas de los que existen más de 700 especies, siendo Hirudo medicinalis la más conocida por su empleo durante más de 2000 años en Medicina. Sin embargo, con el advenimiento de la Medicina científica cayeron en desuso siendo hoy día poco conocidas. Presentamos el caso de un varón de 71 años que consultó en el Servicio de Urgencias por el hallazgo de restos hemáticos en la saliva y sensación de cuerpo extraño en la orofaringe, descubriéndose como causa de los síntomas una infestación accidental por este gusano. Se comenta la rareza de este hallazgo y se describe el empleo actual de la sanguijuela en técnicas de microcirugía reconstructiva, así como los últimos estudios publicados por la producción de sustancias anticoagulantes

Effect of Feeding Low-Oil Ddgs to Laying Hens and Broiler Chickens on Performance and Egg Yolk and Skin Pigmentation

Two experiments were conducted to evaluate the nutritional quality of two sources of low-oil distiller's dried grains with solubles (DDGS) and their pigmenting ability for broiler chicken skin and egg yolks. In Experiment 1, 360 Bovan-White hens between 69 and 77 weeks of age were randomly assigned to five dietary treatments with 6 replicates of 12 hens each. In Experiment 2, 375 Ross 308 broiler chickens were randomly assigned to five treatments with three replicates of 25 birds each. The chickens were fed the experimental diets from one to 42 d of age. In both experiments, treatments consisted of a basal diet with no DDGS, and diets with 6% or 12% inclusion of DDGS from two sources. In Experiment 1, no significant differences in performance were detected among treatments (p> 0.05). Egg yolk pigmentation, according to CR-400 Minolta Colorimeter redness (a) and yellowness (b), linearly increased (p<0.05) with DDGS inclusions. In Experiment 2, no significant differences (p>0.05) were detected among treatments in growth performance, carcass yield, or abdominal fat at 42 d of age. Yellowness linearly increased (p<0.05) in the skin and abdominal fat of the birds that consumed diets with DDGS. The results of the current study indicate that feeding two sources of low-oil DDGS to broiler chicks or laying hens does not negatively affect egg production or growth performance while improves egg yolk and skin yellowness