Propuesta de diseño de un centro logístico para el mejoramiento del servicio de alimentación de STL & SUMINISTROS SAS

SERVICIOS TECNICOS LOGISTICOS & SUMINISTROS SAS, is a company focus on the provision of services to oil companies, these ones are located around the country in cities like Neiva, Yopal, Villavicencio, Barrancabermeja and Rubiales. Providing services related to environmental and sanitary management, infrastructure management and maintenance as well as catering management, hotel and institutional management. Nowadays, the service that represents higher revenue is the food service, representing the 54.5% from June 2015 to June 2016. Nevertheless, the company has been realizing that is losing money due to the waste of food and the lack of control at the supplies reception. Consequently, the company has been working on the improvement of the supply process actually used, however the Solutions aren't enough to minimize the losses that means the company needs to reduce the cost of raw materials and also reduce remains, with the only purpose of keep being alive in the market. The aim of this project was create a logistics center of raw materials, this one has the goal of decrease the waste and cost of supplies and finally increase the revenues of the company. The above was achieved through the use of engineering tools such as flowcharts, layouts, Muther distribution, descriptive statistics, financial indicators, Flexsim, among other things. The logistics center design is based on the Colombian Sectorial Technique Norm NTN USNA 007, the 3075 decree and the 2674 resolution of 2013, which guarantee the quality of the food and the good manufacturing practices. This design was simulate on the Software Flexsim to show the reception process operation, the inspection, the storage, the enlistment and the dispatch, which will perform inside the logistics centre. Finally, the actual Project restriction is based on the implementation cost, because the Company puts a maximum quanty of money to spend. This restriction was totally achieved and shown in the financial analysis.Ingeniero (a) IndustrialPregrad

Propuesta de diseño de un centro logístico para el mejoramiento del servicio de alimentación de STL & SUMINISTROS SAS

SERVICIOS TECNICOS LOGISTICOS & SUMINISTROS SAS, is a company focus on the provision of services to oil companies, these ones are located around the country in cities like Neiva, Yopal, Villavicencio, Barrancabermeja and Rubiales. Providing services related to environmental and sanitary management, infrastructure management and maintenance as well as catering management, hotel and institutional management. Nowadays, the service that represents higher revenue is the food service, representing the 54.5% from June 2015 to June 2016. Nevertheless, the company has been realizing that is losing money due to the waste of food and the lack of control at the supplies reception. Consequently, the company has been working on the improvement of the supply process actually used, however the Solutions aren't enough to minimize the losses that means the company needs to reduce the cost of raw materials and also reduce remains, with the only purpose of keep being alive in the market. The aim of this project was create a logistics center of raw materials, this one has the goal of decrease the waste and cost of supplies and finally increase the revenues of the company. The above was achieved through the use of engineering tools such as flowcharts, layouts, Muther distribution, descriptive statistics, financial indicators, Flexsim, among other things. The logistics center design is based on the Colombian Sectorial Technique Norm NTN USNA 007, the 3075 decree and the 2674 resolution of 2013, which guarantee the quality of the food and the good manufacturing practices. This design was simulate on the Software Flexsim to show the reception process operation, the inspection, the storage, the enlistment and the dispatch, which will perform inside the logistics centre. Finally, the actual Project restriction is based on the implementation cost, because the Company puts a maximum quanty of money to spend. This restriction was totally achieved and shown in the financial analysis.Ingeniero (a) IndustrialPregrad

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification

Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI