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En el trabajo que presentamos hacemos un estudio retrospectivo sobre la utilización de drogas vegetales en la terapéutica popular, siguiendo su evolución y posterior permanencia en las Farmacopeas epañolas. Sorprende el número de recursos terapéuticos obtenidos de la Naturaleza que en las distintas regiones españolas se han usado y la sagacidad que revelan tales conocimientos. Las fuentes documentales consultadas nos dan noticia de lo acontencido en Asturias, Navarra, Galicia, Gran Canaria y otras informaciones engloban múltiples noticias de Castilla, Aragón y Andalucia fundamentalmente. Para cada dolencia tiene el pueblo su remedio, algunos de ellos inocuos pero otros no lo son tanto, sin embargo fueron una realidad que ha sido difícil ir recogiendo de diversos autores, de relatos dispersos de tradiciones, de anotaciones olvidadas de viejos médicos. Hoy estudiamos la panorámica de la terapéutica popular en Galicia, buscando la equivalencia del nombre vulgar por el nombre científico y siguiendo la trayectoria de su pervivencia o desaparición del panorama farmacológico español.In the work which we present we make a retrospective study on the use of vegetable drugs in the popular therapeutics, following its evolution and posterior permanence in the Spanish Pharmacopoeias. We get surprised of the number of therapeutic resources, obtained from Nature and used in diverse Spanish regions, and the sagaclty which reveal such knowledge. The consulted documental sources are giving us notice on what ocurred in Asturias, Navarra, Galicia, Gran Canaria and other information englobe multiple notices on Castilla, Aragón and Andalucia, in particular. For each ailment people have a remedy, some of these remedies are innocuous and ather less. However, these remedies were real and it has been difficult to find out this reality from diverse authors of disperse narratives, from traditions and from forgotten notes by ancient physicians. Today we study the panoramic of the popular therapeutics in Galicia, seeking the equivalence of the common name with the scientific one, and studyng its survival or disappearance from the Spanish pharmalogical panorama

El manuscrito de la “Historia Natural” del Dr. Francisco Fernández Navarrete (S: XVIII)

It has been studied electrochemical reduction of 2,6-bis(morpholino)-4-[(β -hydroxy-etil)-methylamino] -pyrimido(5,4d) pyrimidine (1) and 2,4,6-tris(morpholino)-pyrimido (5,4d) pyrimidine (II).Se ha estudiado la reducción electroquímica sobre el electrodo de gota de mercurio del 2,6-bis(morfolino)-4-[( β-hidroxi-etil)-metil-amino] -pirimido (5,4d)pirimidina(sustancia 1) y 2,4,6, -tris(morfolino )-pirimido(5 ,4d)pirimidina (sustancia II). Los datos oscilopolarográficos ponen de manifiesto que el producto de la reacción catódica se abosrbe intensamente sobre la superficie del electrodo indicador

MEJORAMIENTO DEL PROCESO DE SECADO DE CEREALES EN UNA EMPRESA PRODUCTORA DE ALIMENTO PARA AVES DE CORRAL

A partir de este estudio se creó una propuesta para mejorar el proceso de secado de cereales, teniendo en cuenta que una mala gestión en este proceso, genera retrasos en producción, detrimento de la calidad del producto y por ende riesgos químicos, biológicos y físicos, poniendo en peligro la vida de las aves que se alimentan del producto terminado. Para tal efecto, se realizó un estudio analítico del proceso, encontrándose dos puntos críticos en particular: Una falta de homogeneidad en la humedad de los granos secos y prolongados tiempos de secado. Este estudio ocupó el segundo lugar en la convocatoria de ACAIR

Study of association between Pre-Senile cataracts and the polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish population

To determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development. Methods We have performed a retrospective study over three groups of patients. The group with presenile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes. Results The comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0, 05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0, 05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0, 031; OR = 1.04-15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056). Conclusions Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract

The latest (version 4.3) Mars Climate Database

Introduction: The Mars Climate Database (MCD) is a database of meteorological fields derived from General Circulation Model (GCM) numerical simulations of the Martian atmosphere and validated using available observational data. The MCD includes complementary post-processing schemes such as high spatial resolution interpolation of environmental data and means of reconstructing the variability thereof. The GCM is developed at Laboratoire de Météorologie Dynamique du CNRS (Paris, France) [1,2] in collaboration with the Open University (UK), the Oxford University (UK) and the Instituto de Astrofisica de Andalucia (Spain) with support from the European Space Agency (ESA) and the Centre National d'Etudes Spatiales (CNES)

Analizying MOOCs from an educational perspective in Spain

ABSTRACT: This article is the result of a Teaching Innovation Project funded by the University of Cantabria’s Vice-Rectorate for Teaching Staff. Its goals are to analyze the phenomenon of MOOCs with pedagogical criteria and to develop a Best Practice Guide. The project was developed by the Universities of Cantabria and Oviedo, all the work was divided into three phases: 1) Theoretical review and the design of classroom activities, 2) The implementation of classroom activities and analysis of the main results and 3) The development of a MOOC Best Practice Guide. The results of the second phase at the University of Cantabria are presented here. They demonstrate the need to introduce these massive open online courses into degree programmes in Education, updating higher education studies and providing valuable knowledge for understanding the educational potential (not just technological or financial) of this online training

Modeling the martian atmosphere with the LMD global climate model

Our Global Climate Model (GCM) of the Martian atmosphere is the result of twenty years of ongoing collaboration between our teams and has matured to the point of enabling to study the main cycles (dust, CO2, water) of present-day and past Martian climates. At the 2014 scientific assembly, we will report on the latest developments and improvements of our GCM, and also present the latest version of the Mars Climate Database (version 5.1) that is derived from GCM outputs, along with comparisons with available measurements (from TES, MCS, Viking, Phoenix, Curiosity, etc.)

Nivolumab and sunitinib combination in advanced soft tissue sarcomas : A multicenter, single-arm, phase Ib/II trial

Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As tumor angiogenesis promotes immunosuppression, we designed a phase Ib/II trial to test the double inhibition of angiogenesis (sunitinib) and PD-1/PD-L1 axis (nivolumab). This single-arm, phase Ib/II trial enrolled adult patients with selected subtypes of sarcoma. Phase Ib established two dose levels: level 0 with sunitinib 37.5 mg daily from day 1, plus nivolumab 3 mg/kg intravenously on day 15, and then every 2 weeks; and level-1 with sunitinib 37.5 mg on the first 14 days (induction) and then 25 mg per day plus nivolumab on the same schedule. The primary endpoint was to determine the recommended dose for phase II (phase I) and the 6-month progression-free survival rate, according to Response Evaluation Criteria in Solid Tumors 1.1 (phase II). From May 2017 to April 2019, 68 patients were enrolled: 16 in phase Ib and 52 in phase II. The recommended dose of sunitinib for phase II was 37.5 mg as induction and then 25 mg in combination with nivolumab. After a median follow-up of 17 months (4-26), the 6-month progression-free survival rate was 48% (95% CI 41% to 55%). The most common grade 3-4 adverse events included transaminitis (17.3%) and neutropenia (11.5%). Sunitinib plus nivolumab is an active scheme with manageable toxicity in the treatment of selected patients with advanced soft tissue sarcoma, with almost half of patients free of progression at 6 months

First Observation of the Oxygen 630 nm Emission in the Martian Dayglow

Following the recent detection of the oxygen green line airglow on Mars, we have improved the statistical analysis of the data recorded by the NOMAD/UVIS instrument on board the ExoMars Trace Gas Orbiter mission by summing up hundreds of spectra to increase the signal to noise ratio. This led to the observation of the OI 630 nm emission, a first detection in a planetary atmosphere outside the Earth. The average limb profile shows a broad peak intensity of 4.8 kR near 150 km. Comparison with a photochemical model indicates that it is well predicted by current photochemistry, considering the sources of uncertainty. The red/green line intensity ratio decreases dramatically with altitude as a consequence of the efficient quenching of O(1D) by CO2. Simultaneous observations of the green and red dayglow will provide information on variations in the thermosphere in response to seasonal changes and the effects of solar events

Investigations of the Mars Upper Atmosphere with ExoMars Trace Gas Orbiter

The Martian mesosphere and thermosphere, the region above about 60 km, is not the primary target of the ExoMars 2016 mission but its Trace Gas Orbiter (TGO) can explore it and address many interesting issues, either in-situ during the aerobraking period or remotely during the regular mission. In the aerobraking phase TGO peeks into thermospheric densities and temperatures, in a broad range of latitudes and during a long continuous period. TGO carries two instruments designed for the detection of trace species, NOMAD and ACS, which will use the solar occultation technique. Their regular sounding at the terminator up to very high altitudes in many different molecular bands will represent the first time that an extensive and precise dataset of densities and hopefully temperatures are obtained at those altitudes and local times on Mars. But there are additional capabilities in TGO for studying the upper atmosphere of Mars, and we review them briefly. Our simulations suggest that airglow emissions from the UV to the IR might be observed outside the terminator. If eventually confirmed from orbit, they would supply new information about atmospheric dynamics and variability. However, their optimal exploitation requires a special spacecraft pointing, currently not considered in the regular operations but feasible in our opinion. We discuss the synergy between the TGO instruments, specially the wide spectral range achieved by combining them. We also encourage coordinated operations with other Mars-observing missions capable of supplying simultaneous measurements of its upper atmosphere