Actitudes de los jóvenes limeños (18 a 25 años) en relación al contenido de NETFLIX que incluye temática LGBT y esta comunidad en el 2020

Esta investigación consiste en la compresión de las actitudes de jóvenes limeños de 18 a 25 años frente a contenido transmitido por Netflix con temática LGBT. De esta manera, el plan de investigación tipo básico y con enfoque cualitativo se trabajó bajo un diseño fenomenológico, así pues, se hizo trabajo de campo con 2 grupos de 8 personas cada uno empleando una guía de entrevista para indagar en su punto de vista, opiniones y conductas frente a Netflix y la comunidad LGBT. Asimismo, se aplicó una guía de análisis de contenido para conocer y examinar y conocer las características de las piezas audiovisuales con temática LGBT que Netflix en el 2020. Los resultados de estas intervenciones permitirán encontrar patrones de ideas con respecto a la representación mediática LGBT en la actualidad, así como su importancia o, en el otro caso, su irrelevancia. Así pues, ayudarán a a futuras investigaciones con mirada a fenómenos sociales y culturales

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients