Matrix estimation using matrix forgetting factor and instrumental variable for nonstationary sequences with time variant matrix gain

Consider us the problem of time-varying parameter estimation. The most immediate and simple idea is to include a discounting procedure in an estimation algorithm i.e., a procedure for discarding (forgetting) old information. The most common way to do is to introduce an exponential forgetting factor (FF) into the corresponding estimation procedure (to see: Ljung and Gunnarson (1990)). In this paper, the authors going to describe a good enough estimator considering a system with nonstationary time variant properties with respect to input and output qualities. The techniques used are Instrumental Variable (IV) and Matrix Forgetting Factor (MFF). The results previously obtained by (Poznyak and Medel 1999a, 1999b) were the basis of this paper. The theoretical description illustrates the advantages with respect to others filters below cited.Eje: IV - Workshop de procesamiento distribuido y paraleloRed de Universidades con Carreras en Informática (RedUNCI

Matrix estimation using matrix forgetting factor and instrumental variable for nonstationary sequences with time variant matrix gain

Consider us the problem of time-varying parameter estimation. The most immediate and simple idea is to include a discounting procedure in an estimation algorithm i.e., a procedure for discarding (forgetting) old information. The most common way to do is to introduce an exponential forgetting factor (FF) into the corresponding estimation procedure (to see: Ljung and Gunnarson (1990)). In this paper, the authors going to describe a good enough estimator considering a system with nonstationary time variant properties with respect to input and output qualities. The techniques used are Instrumental Variable (IV) and Matrix Forgetting Factor (MFF). The results previously obtained by (Poznyak and Medel 1999a, 1999b) were the basis of this paper. The theoretical description illustrates the advantages with respect to others filters below cited.Eje: IV - Workshop de procesamiento distribuido y paraleloRed de Universidades con Carreras en Informática (RedUNCI

Matrix estimation using matrix forgetting factor and instrumental variable for nonstationary sequences with time variant matrix gain

Consider us the problem of time-varying parameter estimation. The most immediate and simple idea is to include a discounting procedure in an estimation algorithm i.e., a procedure for discarding (forgetting) old information. The most common way to do is to introduce an exponential forgetting factor (FF) into the corresponding estimation procedure (to see: Ljung and Gunnarson (1990)). In this paper, the authors going to describe a good enough estimator considering a system with nonstationary time variant properties with respect to input and output qualities. The techniques used are Instrumental Variable (IV) and Matrix Forgetting Factor (MFF). The results previously obtained by (Poznyak and Medel 1999a, 1999b) were the basis of this paper. The theoretical description illustrates the advantages with respect to others filters below cited.Eje: IV - Workshop de procesamiento distribuido y paraleloRed de Universidades con Carreras en Informática (RedUNCI

Phosphogypsum waste lime as a promising substitute of commercial limes : a rheological approach

This paper presents the rheological properties of three types of lime putty, specifying the influence of their origin. The study aims to compare a special lime putty prepared from phosphogypsum with a commercial lime powder and an aged lime putty. The results obtained in terms of chemical composition, crystalline structure, grain size and rheological characterization, (linear viscoelasticity, shear rate and time-dependent flow behaviour) are presented in the study. Putties studied present a similar rheological response, which mainly depends on the particle size and water content. Lower values of the linear viscoelastic functions and viscosity were found for the phosphogypsum lime putty, in agreement with the higher particle size. Transient flow tests reveal a predominant elastic response with no significant shear-induced structural perturbations. However, either a thickening phenomenon over time, i.e. rheopexy, favoured at low shear rates, or a viscosity decrease, i.e. thixotropy, favoured at high shear rates, was observed.The authors would like to thank the aid of CITIUS at the University of Seville for the use of their laboratories for the characterization analyses. A.M.B.-L. has received a Ph.D. Research Grant from the Ministerio de Education, Cultura y Deporte (FPU16/03697)

Characterization and Analysis of the Carbonation Process of a Lime Mortar Obtained from Phosphogypsum Waste

This work addresses the reuse of waste products as a raw material for lime putties, which are one of the components of mortar. 1:3 Lime/sand mortars very similar to conventional construction mortars were prepared using a lime putty obtained from the treatment of phosphogypsum with sodium hydroxide. The physical, rheological and mechanical properties of this phosphogypsum-derived mortar have been studied, as well as the mineralogical composition, microstructure by scanning electron microscope (SEM) and curing process by monitoring carbonation and ultrasonic propagation velocity. Considering the negative influence of sulphates on the hardened material, the behaviour of the material after sulphates precipitation by adding barium sulphate was additionally tested. Carbonation progressed from the outside to the inside of the specimen through the porous system by Liesegang rings patterns for mortars with soluble sulphates, while the carbonation with precipitated sulphates was controlled by diffusion-precipitation. Overall, the negative influence of low-sulphate contents on the mechanical properties of mortars was verified. It must be highlighted the importance of their precipitation to obtain adequate performance.This research was funded by Programa Estatal I+D+i Retos de la Sociedad of the Ministry of Science and Innovation (Spain), which supported this research (MAT2017-84228-R research project)

Preservation of Synchronization Using a Tracy‐Singh Product in the Transformation on Their Linear Matrix

Preservation is related to local asymptotic stability in nonlinear systems by using dynamical systems tools. It is known that a system, which is stable, asymptotically stable, or unstable at origin, through a transformation can remain stable, asymptotically stable, or unstable. Some systems permit partition of its nonlinear equation in a linear and nonlinear part. Some authors have stated that such systems preserve their local asymptotic stability through the transformations on their linear part. The preservation of synchronization is a typical application of these types of tools and it is considered an interesting topic by scientific community. This chapter is devoted to extend the methodology of the dynamical systems through a partition in the linear part and the nonlinear part, transforming the linear part using the Tracy-Singh product in the Jacobian matrix. This methodology preserves the structure of signs through the real part of eigenvalues of the Jacobian matrix of the dynamical systems in their equilibrium points. The principal part of this methodology is that it permits to extend the fundamental theorems of the dynamical systems, given a linear transformation. The results allow us to infer the hyperbolicity, the stability and the synchronization of transformed systems of higher dimension

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24-null progeroid mice, which exhibit nuclear lamina defects. We show that Zmpste24 deficiency causes an alteration in the number and proliferative capacity of epidermal stem cells. These changes are associated with an aberrant nuclear architecture of bulge cells and an increase in apoptosis of their supporting cells in the hair bulb region. These alterations are rescued in Zmpste24−/−Lmna+/− mutant mice, which do not manifest progeroid symptoms. We also report that molecular signaling pathways implicated in the regulation of stem cell behavior, such as Wnt and microphthalmia transcription factor, are altered in Zmpste24−/− mice. These findings establish a link between age-related nuclear envelope defects and stem cell dysfunction

Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma

This article belongs to the Special Issue Advances in Multiple Myeloma Research and Treatment.[Simple Summary] Although the majority of patients with myeloma who achieve undetectable minimal residual disease show prolonged survival, some of them relapse shortly afterwards. False-negative results due to hemodiluted bone marrow samples could explain this inconsistency, but there is no guidance on how to evaluate them. We analyzed three cell populations normally absent in peripheral blood in 1404 aspirates obtained in numerous disease settings and in 85 healthy adults. Pairwise comparisons according to age and treatment showed significant variability, thus suggesting that hemodilution should be preferably evaluated with references obtained after receiving identical regimens. Leveraging the minimal residual disease results from 118 patients, we showed that a comparison with age-matched healthy adults could also inform on potential hemodilution. Our study supports the routine assessment of bone marrow cellularity to evaluate hemodilution, using as reference values either treatment-specific or from healthy adults if the former are unavailable.[Abstract] Background: Whereas, in most patients with multiple myeloma (MM), achieving undetectable MRD anticipates a favorable outcome, some others relapse shortly afterwards. Although one obvious explanation for this inconsistency is the use of nonrepresentative marrow samples due to hemodilution, there is no guidance on how to evaluate this issue. Methods: Since B-cell precursors, mast cells and nucleated red blood cells are normally absent in peripheral blood, we analyzed them in 1404 bone marrow (BM) aspirates obtained in numerous disease settings and in 85 healthy adults (HA). Results: First, we confirmed the systematic detection of the three populations in HA, as well as the nonreduced numbers with aging. Pairwise comparisons between HA and MM patients grouped according to age and treatment showed significant variability, suggesting that hemodilution should be preferably evaluated with references obtained from patients treated with identical regimens. Leveraging the MRD results from 118 patients, we showed that a comparison with HA of similar age could also inform on potential hemodilution. Conclusions: Our study supports the routine assessment of BM cellularity to evaluate hemodilution, since reduced BM-specific cell types as compared to reference values (either treatment-specific or from HA if the former are unavailable) could indicate hemodilution and a false-negative MRD result.This study was supported by grants from the Centro de Investigación Biomédica en Red—Área de Oncología—del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369, CB16/12/00400, CB16/12/00233 and CB16/12/00284); Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria and co-financed by FEDER funds (FIS No. PI15/01956, PI15/02049, PI15/02062, PI18/01709, PI18/01673 and PI19/01451); the Cancer Research UK (C355/A26819), FCAECC and AIRC under the Accelerator Award Programme (EDITOR); the Black Swan Research Initiative of the International Myeloma Foundation and the European Research Council (ERC) 2015 Starting Grant (Contract 680200 MYELOMANEXT). This study was supported by the Riney Family Multiple Myeloma Research Program Fund