Procedimiento para la obtención de derivados acetilénicos y alénicos de 2-aminometil-(1-metil-indoles)

Referencia OEPM: P8900562.-- Fecha de solicitud: 16/02/1989.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).Se describe un procedimiento nuevo para la preparación de derivados acetilénicos y alénicos de 2-aminometil-(1-metilindoles). Se parte de los correspondientes ácidos 1-metilindol-2-carboxílicos que por reacción preferentemente con pentacloruro de fósforo en éter se transforma en el correspondiente cloruro de ácido, el cual tratado con amoníaco o aminas conduce a las respectivas amidas. Las amidas se reducen con hidruro de litio y aluminio, preferentemente en tetrahidrofurano a reflujo para dar las correspondientes 2-aminometil-(1-metilindoles), que se acilan y caracterizan como bases libres o alguna de sus sales, generalmente hidrocloruros. Finalmente estas aminas se hacen reaccionar los bromuros de 2-propinilo, de 2-butinilo y de 2,3-butadienilo, en presencia de terc-butilamina para dar los N-(2-propinil) N-(2-butinil) y N-(2,3-butadienil) derivados de los respectivos 2-amino metil-(1-metilindoles) que se caracterizan como bases libres o como alguna de sus sales. Los compuestos finales obtenidos son activos como inhibidores de monoaniuro oxidasas.Peer reviewe

Formation of b-Bi2O3 and d-Bi2O3 during laser irradiation of Bi films studied in-situ by spatially resolved Raman spectroscopy

The formation of different phases of Bi2O3 induced by laser irradiation of Bi films has been assessed in situ by micro-Raman spectroscopy as a function of laser wavelength, power density and irradiation time. Raman mapping of the irradiated samples enabled a spatially-resolved study of the distribution of the formed Bi2O3 phases. Red laser (633 nm) irradiation was found to induce the appearance of b-Bi2O3, within a certain range of power densities, by diffusion-controlled processes. In contrast, ultraviolet (UV, 325 nm) laser irradiation, above a certain power density threshold, initially induces the formation of both b and d-Bi2O3 phases. The amount of the produced d-Bi2O3 phase increases by increasing the irradiation time, while that of the b phase follows the opposite trend. UV laser irradiation seems to be a suitable method to produce room temperature stable d-Bi2O3 patterns on Bi film

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Sin resume

Experimental.numerical correlation of a padel racket subject to impact

Los artículos deportivos son cada vez más sofisticados y requieren de soluciones de alta tecnología para la mejora de sus prestaciones. Un ejemplo de esto pueden ser las palas de pádel, que deben aunar características como ligereza, rigidez y durabilidad. La respuesta a estos requerimientos es una estructura multimaterial, formada por materiales compuestos, principalmente fibra de vidrio y carbono, resinas poliméricas y espumas de alta tecnología. Los fabricantes se enfrentan a multitud de variables durante la fase de diseño (forma, materiales, distribución de agujeros, …) que dotan a la pala de unas características propias y que no son capaces de evaluar hasta que los jugadores las prueban. Es en ese momento cuando, en función de las sensaciones de cada tipo de jugador, se valida la calidad de la pala y el perfil de jugador al que irá dirigida. Este procedimiento prueba-error supone un elevado coste material y alarga el periodo de desarrollo de un nuevo producto. El objetivo de este trabajo, desarrollado en colaboración con la empresa Shark Pádel S.L., es desarrollar un modelo de elementos finitos que permita definir parámetros ingenieriles del comportamiento de la pala, que traduzcan las sensaciones de los jugadores, para posteriormente poder evaluar su comportamiento al variar cualquiera de los parámetros de diseño.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dorsolateral periaqueductal grey matter and pontine A5 region connectivity: a neuropharmacologic and electrophysiological study

In this study, carried out in spontaneously breathing anesthetised rats, we have analysed the relevance of the interactions between the dorsolateral periaqueductal grey matter (dlPAG) and the A5 region, and how this sympathetic pontine region participates in modulating the cardiorespiratory response evoked from the dlPAG. Electrical stimulation of the dlPAG (1 ms pulses, 20-30 μA given at 100 Hz for 5s) was elicited, and the evoked cardiorespiratory changes were analysed before and after ipsilateral microinjections of muscimol (50 nl, 0.25 nmol, 5s) within the A5 region. DlPAG stimulation evoked the classical “defence response” characterized by tachipnoea, hypertension and tachycardia. Tachipnoea consisted of an inspiratory facilitatory response [increase in respiratory rate (p<0.001) due to a decrease in expiratory time (p<0.01)] and was accompanied by a pressor (p<0.001) and tachycardic (p<0.001) response. Microinjection of Muscimol within the A5 region reduced all, pressor (p<0.05), heart rate (p<0.001) and respiratory (p<0.001) responses evoked by electrical stimulation of dlPAG. Finally, extracellular recordings of putative A5 neurones were obtained during dlPAG electrical stimulation in order to assess functional interactions between A5 and dlPAG. Forty A5 cells were recorded, 16 of which were affected by dlPAG (40%). With these results, we can conclude that neurones of the A5 region possibly modulate the cardiorespiratory response evoked from the dlPAG.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Does the midbrain dorsolateral periaqueductal grey have direct connections with the pontine A5 region? A neuropharmacologic and electrophysiological study

This study has been performed in spontaneously breathing anesthetised rats. We have analysed the possible interactions between the midbrain dorsolateral periaqueductal grey matter (dlPAG) and the pontine A5 region. Electrical stimulations of the dlPAG (1 ms pulses, 20-30 μA given at 100 Hz for 5s) were elicited and the evoked cardiorespiratory changes were analysed before and after ipsilateral blockade of the neurotransmission within the A5 region by means of microinjections of muscimol (50 nl, 0.25 nmol, 5s). Electrical stimulations evoked the classical “defence response” characterized by tachipnoea, hypertension and tachycardia. Tachipnoea consisted of an inspiratory facilitatory response [increase in respiratory rate (p<0.001) due to a decrease in expiratory time (p<0.01)] and was accompanied by a pressor (p<0.001) and tachycardic (p<0.001) response. Muscimol microinjected within the A5 region reduced pressor (p<0.05), tachycardic (p<0.001) and tachypnoeic (p<0.001) responses evoked to dlPAG electrical stimulations. Finally, in order to assess functional interactions between A5 and dlPAG, extracellular recordings of 40 putative A5 cells during dlPAG electrical stimulation were recorded. 16 cells were affected by dlPAG stimulation (40%). 3 cells showed orthodromic activation (14.2 ± 1.7 ms). 5 cells were excited (10.1 ± 1.6 ms). 7 cells decreased spontaneous activity to dlPAG stimulation. 24 cells were not modified by dlPAG stimulation (2 presented a respiratory pattern and 1 presented a cardiovascular pattern). These results contribute with new data on the role of the A5 region neurones in the modulation of the cardiorespiratory response evoked on dlPAG stimulation.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Impact of the COVID-19 Pandemic on the Diagnosis and Prognosis of Melanoma

Background: Early detection of melanoma is one of the main diagnostic goals of dermatologists worldwide, due to the increasing incidence of the disease in our environment. However, the irruption of the SARS-CoV-2 pandemic has posed a challenge to global healthcare, forcing systems to focus their resources on the fight against COVID-19. Methods: Retrospective cohort study. The exposed cohort were patients diagnosed with melanoma in the year after the general confinement in Spain (15 March 2020) and the unexposed cohort were patients with melanoma diagnosed in the previous year. Results: 130 patients were included. No differences were observed between demographic characteristics in both cohorts. The mean Breslow of melanoma before the onset of the pandemic was 1.08, increasing to 2.65 in the year after the onset of the pandemic (p < 0.001). On the other hand, the percentage of melanomas in situ decreased from 38.96% to 16.98% in the year after the declaration of the state of alarm in Spain. Conclusions: The SARS-CoV-2 outbreak has led to a reduction in the early diagnosis of melanoma, with an increase in invasive melanomas with poor prognosis histological factors. This could lead to an increase in melanoma-related mortality in the coming years in our environment

Energy Efficiency of Personal Computers: A Comparative Analysis

The demand for electricity related to Information and Communications Technologies is constantly growing and significantly contributes to the increase in global greenhouse gas emissions. To reduce this harmful growth, it is necessary to address this problem from different perspectives. Among these is changing the computing scale, such as migrating, if possible, algorithms and processes to the most energy efficient resources. In this context, this paper explores the possibility of running scientific and engineering programs on personal computers and compares the obtained power efficiency on these systems with that of mainframe computers and even supercomputers. Anecdotally, this paper also shows how the power efficiency obtained for the same workloads on personal computers is similar to that obtained on supercomputers included in the Green500 ranking.Spanish GovernmentEuropean Commission PGC2018-098813-B-C31 MICI

Structural Phase Transitions of Hybrid Perovskites CH₃NH₃PbX₃ (X = Br, Cl) from Synchrotron and Neutron Diffraction Data

Methylammonium (MA) lead trihalide perovskites, that is, CH3NH3PbX3 (X = I, Br, Cl), have emerged as a new class of light-absorbing materials for photovoltaic applications. Indeed, since their implementation in solar-cell heterojunctions, they reached efficiencies above 23%. From a crystallographic point of view, there are many open questions that should be addressed, including the role of the internal motion of methylammonium groups within PbX6 lattice under extreme conditions, such as low/high temperature or high pressure. For instance, in MAPbBr3 perovskites, the octahedral tilting can be induced upon cooling, lowering the space group from the aristotype Pm3¯m to I4/mcm and Pnma. The band gap engineering brought about by the chemical management of MAPb(Br,Cl)3 perovskites has been controllably tuned: the gap progressively increases with the concentration of Cl ions from 2.1 to 2.9 eV. In this chapter, we review recent structural studies by state-of-the-art techniques, relevant to the crystallographic characterization of these materials, in close relationship with their light-absorption properties