Caracterización del 'Knock out' en Boxeo

El objetivo de este trabajo es identificar las cuatro últimas acciones motrices emitidas (golpes) por boxeadores campeones del mundo de los pesos pesados y así poder caracterizar el 'Knock out' en boxeo. Para ello, hemos desarrollado una herramienta de observación que consta de cuatro criterios y 35 categorías. Para la selección de la muestra se tuvo en cuenta dos requisitos: haberse proclamado campeón del mundo del peso pesado durante el período que comprende 1921-2007 (desde Jack Dempsey hasta Ruslan Chagaev) y la disponibilidad digital de las imágenes para su análisis. Se obtuvieron datos relativos a la secuencia de acciones motrices que anteceden a la finalización de los combates en boxeo, medido a través de los últimos cuatro golpes lanzados por el ganador. Los resultados del estudio muestran que el 'Knock out' en boxeo suele darse haciendo un uso mayoritario de ciertos golpes entre los contendientes, presentando diferencias significativas

The difficulties of adapting university teaching for students with disabilities: an analysis focussed on inclusive guidance

The need for specific attention for the personal, social, academic and professional development of students with disabilities is a challenge that the university is committed to. Although significant progress has been made, promoted by an inclusive educational approach, there are still many difficulties faced by students to intergrate into university education. To advance a deeper understanding of the issues affecting these students, research has been conducted with a sample of 113 students with disabilities from different centers in the University of La Laguna (Spain). The results have highlighted, the lack of guidance and information regarding access to university courses, the need to implement support measures to assist the learning process and also the urgency for improving institutional policies favouring the disabled.

Las dificultades de adaptación a la enseñanza universitaria de los estudiantes con discapacidad: un análisis desde un enfoque de orientación inclusiva

La necesidad de una atención específica para el desarrollo personal, social, académico y profesional del alumnado con discapacidad es un reto que tiene contraída la institución universitaria. Aunque ha habido avances importantes promovidos desde un enfoque de educación inclusiva, son todavía muchas las dificultades a las que se enfrentan los estudiantes para integrarse en los estudios universitarios. Para avanzar en un conocimiento más profundo de los problemas que afectan a estos estudiantes, se ha llevado a cabo una investigación con una muestra de 113 estudiantes con discapacidad de distintos centros de la Universidad de La Laguna, que ha puesto de manifiesto la falta de orientación e información con la que afrontan el acceso a los estudios universitarios, la necesidad de implantar medidas de apoyo para facilitar el proceso de aprendizaje y la urgencia de mejorar las políticas institucionales en favor de la discapacidad

Quistes de colédoco, una causa inusual de ictericia en pediatría. Presentación de serie de casos

ResumenIntroducciónLos quistes de la vía biliar o quistes de colédoco (QC) son una patología rara en nuestro medio. La etiología es desconocida, siendo la hipótesis más aceptada las anomalías en la unión biliopancreática.ObjetivoAnalizar los datos clínicos, diagnóstico y tratamiento de una serie de pacientes diagnosticados de QC y realizar una actualización sobre el tema.MetodoSe revisaron retrospectivamente los diagnósticos de QC en 20 años en un hospital terciario.Casos clínicosSe identificaron 4 casos, con predominio del sexo femenino. Rango de edad 16 meses a 4 años. Los signos y síntomas fueron ictericia y coluria (100%), vómitos (75%), dolor abdominal y acolia (50%). Ninguno tuvo masa palpable. La ecografía abdominal orientó el diagnóstico que se confirmó con colangio-resonancia magnética (colangio-RM). Se clasificaron como QC tipo I tres de los casos y uno como tipo IVa. El tratamiento fue quirúrgico, ningún paciente presentó complicaciones hasta la fecha.ConclusionesLos quistes de las vías biliares son de baja prevalencia. El tratamiento de elección es quirúrgico, requiriendo seguimiento estrecho, dado el riesgo de colangiocarcinoma.AbstractIntroductionCysts of the bile duct or choledochal cysts are rare diseases in our area. The aetiology is unknown, with the most accepted hypothesis being a pancreatobiliary maljunction anomaly.ObjectiveTo analyse the clinical data, diagnosis and treatment of a number of patients with choledochal cyst, as well as presenting an update on this condition.MethodA retrospective descriptive study was performed on paediatric patients diagnosed with choledochal cyst in the last 20 years in a tertiary hospital.Case reportsA total of 4 choledochal cyst cases in childhood, predominantly female, are pre- sented. The most frequent reason for consultation was vomiting, and presenting with jaundice and choluria in all cases. Patients with choledochal cyst were classified as type I in 3 cases, and one case of type IVa. In all cases surgical treatment was performed; any patient had complications to date.ConclusionsCysts of the bile ducts have a low prevalence. The treatment of choice is surgical, requiring close monitoring due to the risk of cholangiocarcinoma

Selective linkage detection of O-sialoglycan isomers by negative electrospray ionization ion trap tandem mass spectrometry

9 páginas, 6 figuras, 2 esquemas.-- El pdf del artículo es la versión de autor.Sialylated O-linked oligosaccharides are involved in many biological processes, such as cell-cell interactions, cell-substance adhesion, and virus-host interactions. These activities depend on their structure, which is frequently determined by tandem mass spectrometry. However, these spectra are frequently analyzer-dependent, which makes it difficult to develop widely applicable analytical methods. In order to deepen the origin of this behavior, two couples of isomers of sialylated O-linked oligosaccharides, NeuAcα2-3Galβ1-3GalNAc-ol/Galβ1-3(NeuAcα2-6)GalNAc-ol and NeuGcα2-3Galβ1-3GalNAc-ol/Galβ1-3(NeuGcα2-6)GalNAc-ol, were analyzed by liquid chromatography/negative electrospray ionization ion trap tandem mass spectrometry (LC/ESI(−)-MSn) using both an ion trap and a triple quadrupole mass spectrometer. Results clearly showed that while ions obtained in the triple quadrupole instrument fitted very well with the standard fragmentation routes, in the ion trap several intense ions could not be explained by these rules, specially a fragment at m/z 597. Furthermore, this ion was observed in the mass spectrum of those isomers that sialic acid binds to GalNAc by an α2-6 linkage. From the MS3 spectrum of this ion an unexpected structure was deduced, and it led to propose alternative fragmentation pathways. Molecular mechanics calculations suggested that the found atypical route could be promoted by a hydrogen bond located only in α2-6-linked oligosaccharides. It has also been demonstrated that this process follows a slow kinetic, explaining why it cannot be observed using an ion beam-type mass analyzer. In conclusion, ion traps seem to be more appropriate than triple quadrupoles to develop a reliable analytical method to distinguish between isomeric O-linked glycans.Financial support was obtained from projects ANALISYC S-0505/ AGR/000312 from the Comunidad de Madrid, Consolider Ingenio 2010 (FUN-C-FOOD); CSD 2007-00063 from the Ministerio de Educación y Ciencia; and PIF-SIALOBIOTIC 200870F010-1 and -2 from CSIC.Peer reviewe

Propuesta de un planeamiento tributario para evitar contingencias tributarias, en una empresa constructora

El estudio tuvo como objetivo formular una propuesta de planeamiento tributario, siguió una metodología de tipo de tipo descriptivo, no experimental y propositivo. Se apoya en las técnicas de análisis documental, así como la encuesta sobre la existencia del planeamiento tributario. Como instrumentos, consideró a la guía de análisis documentario y al cuestionario, por lo cual partió del análisis de los estados financieros, los ingresos, egresos y las obligaciones tributarias con todo ello se realizó el diagnóstico actual de la empresa. Los resultados evidenciaron conocimiento tributario de regular a bueno, en planeamiento en ingresos se advirtió porcentajes similar en los niveles regular y bueno. Sobre el planeamiento en egresos, se observa que ampliamente es regular y en menor porcentaje es bueno; similares resultados se encuentran en torno a las obligaciones tributarias. Asimismo, en torno al análisis documental se advirtieron una variedad de inconsistencias que reflejan incumplimiento de las obligaciones tributarias, afectaciones en los ingresos y egresos en la empresa. Se concluye que el planeamiento tributario es de regular (42,9%) a bueno (52,4%), asimismo el análisis de los estados financieros evidencia una falta de planeación en materia, por consiguiente, la formulación de la propuesta tuvo como finalidad mejorar el cumplimiento tributario empresarial, por medio de la aplicación de herramientas de gestión, contables y tributarias para así anticiparse a los hechos que afectan el correcto proceso en la empresa.LIMAEscuela Profesional de ContabilidadTributo

Comparative proteomic analysis of nuclear and cytoplasmic compartments in human cardiac progenitor cells.

Clinical trials evaluating cardiac progenitor cells (CPC) demonstrated feasibility and safety, but no clear functional benefits. Therefore a deeper understanding of CPC biology is warranted to inform strategies capable to enhance their therapeutic potential. Here we have defined, using a label-free proteomic approach, the differential cytoplasmic and nuclear compartments of human CPC (hCPC). Global analysis of cytoplasmic repertoire in hCPC suggested an important hypoxia response capacity and active collagen metabolism. In addition, comparative analysis of the nuclear protein compartment identified a significant regulation of a small number of proteins in hCPC versus human mesenchymal stem cells (hMSC). Two proteins significantly upregulated in the hCPC nuclear compartment, IL1A and IMP3, showed also a parallel increase in mRNA expression in hCPC versus hMSC, and were studied further. IL1A, subjected to an important post-transcriptional regulation, was demonstrated to act as a dual-function cytokine with a plausible role in apoptosis regulation. The knockdown of the mRNA binding protein (IMP3) did not negatively impact hCPC viability, but reduced their proliferation and migration capacity. Analysis of a panel of putative candidate genes identified HMGA2 and PTPRF as IMP3 targets in hCPC. Therefore, they are potentially involved in hCPC proliferation/migration regulation.THis study was initiated by European Commission funding (HEALTH-2009_242038) and by grants to AB from the Spanish Ministry of Science and Innovation RTI2018-097604-B-I00 (AEI/FEDER, UE) and SAF2015- 70882-R. Te Research Program of the Comunidad Autónoma de Madrid (S2017/BMD-3692) and the Instituto de Salud Carlos III (RETICS-RTI2018-097604-B-I00) to AB also funded parts of the work. We also wish to thank to K McCreath for editorial work.S

Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity

A facile, fast and green strategy based on ethanol is utilized to prepare a new bioMOF, namely, CaSyr-1, with particular characteristics of full biocompatibility given by using just calcium and syringic acid, the latter being a phenolic natural product found in fruits and vegetables, permanent porosity with an outstanding surface area >1000 m2 g−1, and a micropore diameter of 1.4 nm close to mesopore values. Collectively, these data establish CaSyr-1 as one of the most porous bioMOFs reported to date, with high molecular adsorption capacity. The CaSyr-1 adsorptive behavior is revised here through the reversible adsorption of CO2 and the encapsulation of bioactive ingredients in the structure. Remarkably, CaSyr-1 enables the development of triple therapeutic entities, involving bioactive Ca2+, syringic acid and an impregnated drug

Proanthocyanidin characterization and bioactivity of extracts from different parts of Uncaria tomentosa L. (cat’s claw)

This article belongs to the Special Issue Dietary Antioxidants and Health Promotion.-- et al.Apart from alkaloids, bioactive properties of Uncaria tomentosa L. have been attributed to its phenolic constituents. Although there are some reports concerning low-molecular-weight polyphenols in U. tomentosa, its polymeric phenolic composition has been scarcely studied. In this study, phenolic-rich extracts from leaves, stems, bark and wood (n = 14) of Uncaria tomentosa plants from several regions of Costa Rica were obtained and analysed in respect to their proanthocyanidin profile determined by a quadrupole-time-of-flight analyser (ESI-QTOF MS). Main structural characteristics found for U. tomentosa proanthocyanidins were: (a) monomer composition, including pure procyanidins (only composed of (epi)catechin units) and propelargonidins (only composed of (epi)afzelechin units) as well as mixed proanthocyanidins; and (b) degree of polymerization, from 3 up to 11 units. In addition, U. tomentosa phenolic extracts were found to exhibit reasonable antioxidant capacity (ORAC (Oxygen Radical Absorbance Capacity) values between 1.5 and 18.8 mmol TE/g) and antimicrobial activity against potential respiratory pathogens (minimum IC of 133 µg/mL). There were also found to be particularly cytotoxic to gastric adenocarcinoma AGS and colon adenocarcinoma SW620 cell lines. The results state the particularities of U. tomentosa proanthocyanidins and suggest the potential value of these extracts with prospective use as functional ingredients.This project was partially funded by grant from the Spanish International Development Cooperation Agency (AECID) (Ref. A/023397/09 and A/030037/10) and a joint grant from the Costa Rica-USA Foundation (CRUSA) and the Spanish Scientific Research Council (CSIC) (Ref. CR0024). Authors also thank financial support from the Comunidad de Madrid (Spain) and European funding from FEDER program (projects AVANSECAL-CM S2013/ABI-3028 and ALIBIRD-CM S2013/ABI-2728) and from the University of Costa Rica. Special thanks are due to Eng. Juan Jose Cordero from Costa Rican National Production Council (CNP).Peer Reviewe

Impact of Implementing a Dyslipidemia Management Guideline on Cholesterol Control for Secondary Prevention of Ischemic Heart Disease in Primary Care

Cardiovascular diseases (CVD) are the main cause of death worldwide. The control of CVD risk factors, such as dyslipidemia, reduces their mortality rate. Nonetheless, fewer than 50% of patients with ischemic heart disease (IHD) have good cholesterol control. Our objective is to assess whether the level of participation of general practitioners (GPs) in activities to implement a dyslipidemia management guideline, and the characteristics of the patient and physician are associated with cholesterol control in IHD patients. We undertook a quasi-experimental, uncontrolled, before-and-after study of 1151 patients. The intervention was carried out during 2010 and 2011, and consisted of a face-to-face training and online course phase (Phase 1), and another of face-to-face feedback (Phase 2). The main outcome variable was the low-density lipoprotein cholesterol (LDL-C) control, whereby values of <100 mg/dL (2.6 mmol/L) were set as a good level of control, according to the recommendations of the guidelines in force in 2009. After Phase 1, 6.7% more patients demonstrated good cholesterol control. With respect to patient characteristics, being female and being older were found to be risk factors of poor control. Being diabetic and having suffered a stroke were protective factors. Of the GPs' characteristics, being tutor in a teaching center for GP residents and having completed the online course were found to be protective factors. We concluded that cholesterol control in IHD patients was influenced by the type of training activity undertook by physicians during the implementation of the GPC, and patient and physician characteristics. We highlight that if we apply the recent targets of the European guideline, which establish a lower level of LDL-C control, the percentage of good control could be worse than the observed in this study