Construcción de un cancionero y romancero efímero en la Corte Del III Duque de Calabria

Entre 1525 e 1538, a corte dos duques da Calábria (Fernando de Aragão e Germana de Foix) conheceu um período de esplendor literário e musical que não mais se voltaria a repetir numa corte espanhola não pertencente à Coroa. Alguns dos maiores músicos e escritores deste período viveram sob os auspícios de ambos os vice-reis de Valência, e muitos outros beneficiaram ocasionalmente do mecenato do terceiro duque da Calábria. Tal ambiente literário-musical, juntamente com o gosto da rainha viúva de Fernando I, o Católico, Germana de Foix, pelas festas, saraus e celebrações ao gosto francês favoreceram a paulatina criação duma literatura cortesã de carácter efémero e de circunstância, baseada na recuperação, para os salões, dos populares romances e da lírica de tipo tradicional. Neste tipo de literatura tão extremamente volátil, destacaram-se os poetas valencianos Luis Milán e Joan Fernández de Heredia, artífices dum género de composições poéticas destinadas a dissolver-se entre as gargalhadas dos homens do palácio de Liria

Bartolomé de Torres Naharro, Teatro completo, edición de Julio Vélez-Sainz

A Bartolomé de Torres Naharro (1485-1520) le corresponde la publicación de la primera preceptiva teatral en lengua romance de la que tenemos constancia y su obra dramática alcanzó una difusión impresa durante el siglo XVI que superaría con creces la de otros dramaturgos de la talla de Juan del Encina, Gil Vicente o Lope de Rueda. Sin embargo, desde la magna edición de Joseph E. Gillet de Propalladia and Other Works of Bartolomé de Torres Naharro a mediados del siglo pasado, esta que ahora com..

La escenificación de la paz: ópera y diplomacia en la Paz de los Pirineos

Este ensayo estudia las producciones operísticas realizadas en España y en Francia con motivo de la celebración de la Paz de los Pirineos y el matrimonio entre la infanta María Teresa de Austria y Luis XIV de Francia. De parte española se analiza La púrpura de la rosa (1660), escrita por Pedro Calderón de la Barca con música de Juan Hidalgo, mientras que de la parte francesa nos detenemos en las representaciones de Xerses (1654, 1660) de Francesco Cavalli y Nicolò Minato y l’Ercole amante (1662) del compositor italiano y Francesco Buti. El estudio comparativo de estas obras nos permite adivinar algunos de los usos y utilidades diplomáticas de la ópera para construir ante las potencias extranjeras un relato favorable a los intereses nacionales propios.This essay studies the operatic productions made in Spain and France to commemorate the Peace of the Pyrenees and the marriage between the Infanta María Teresa of Austria and Louis XIV of France. On the Spanish side, we analyze La purpura de la rosa (1660), written by Pedro Calderón de la Barca with music by Juan Hidalgo. On the French side, we take into consideration the representations of Xerses (1654, 1660) by Francesco Cavalli and Nicolò Minato and l’Ercole amante (1662) by the Italian composer and Francesco Buti. This comparative study allows us to enter into the opera’s diplomatic uses of both sides of the Pyrenees to construct narratives favorable to their own national interests and inf luence foreign powers’ representatives

Influence of the calcination temperature on the activity of hydroxyapatite-supported palladium catalyst in the methane oxidation reaction

In the present study, a series of four hydroxyapatite (HAP) supported palladium samples, with a Pd loading close to 0.5 %, obtained through their calcination at 773, 873, 973, or 1073 K has been investigated. These samples have been characterized using a wide battery of complementary techniques. From these studies, it was found that the rise of the calcination temperature induces a progressive dehydroxylation of the support and a structure evolution of the species containing Pd 2+ , from tetrahedral (Td) to square planar geometry (D 4h ). Moreover, this enhances markedly the metal-support interactions. For instance, at the highest temperature (1073 K), Pd particles were found encapsulated by a thin support layer. Consequently, two distinct reducible species have been identified; one of them manifests SMSI. This increase in the Pd-HAP interaction strength seems to (i) expand the HAP lattice, (ii) change the Pd 2+ coordination from Td to D 4h geometry, (iii) promote PdO reduction and (iv) suppress CO chemisorption. These entire properties do compensate the poor textural properties and benefit the efficiency and stability of the Pd active phase in methane oxidation reaction.Ministerio de Economía y Competitividad (CTQ2015-73219-JIN (AEI/FEDER/UE) and CTQ2016-80253-R (AEI/FEDER/UE)) // Basque Government (GIC IT-1297-19) // University of the Basque Country UPV/EHU (PIF15/335

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Bartolomé de Torres Naharro, Teatro completo. Edición de Julio Vélez-Sainz. Madrid, Cátedra, 2013, 1104 p.

Bartolomé de Torres Naharro (1485-1520) es, sin lugar a dudas, uno de los autores más importantes e interesantes de la historia del teatro español. A él le corresponde la publicación de la primera preceptiva teatral en lengua romance de la que tenemos constancia y su obra dramática alcanzó una difusión impresa durante el siglo xvi que superaría con creces la de otros dramaturgos de la talla de Juan del Encina, Gil Vicente o Lope de Rueda. Sin embargo, desde la magna edición de Joseph E. Gille..

"Don Gil de las calzas verdes" [Reseña]

Reseña de Tirso de Molina, "Don Gil de las calzas verdes", Ed. Enrique García Santo-Tomás, Madrid: Cátedra. 2010. 2ª edición, 218 pp

La escenificación de la paz: ópera y diplomacia en la Paz de los Pirineos

Este ensayo estudia las producciones operísticas realizadas en España y en Francia con motivo de la celebración de la Paz de los Pirineos y el matrimonio entre la infanta María Teresa de Austria y Luis XIV de Francia. De parte española se analiza La púrpura de la rosa (1660), escrita por Pedro Calderón de la Barca con música de Juan Hidalgo, mientras que de la parte francesa nos detenemos en las representaciones de Xerses (1654, 1660) de Francesco Cavalli y Nicolò Minato y l’Ercole amante (1662) del compositor italiano y Francesco Buti. El estudio comparativo de estas obras nos permite adivinar algunos de los usos y utilidades diplomáticas de la ópera para construir ante las potencias extranjeras un relato favorable a los intereses nacionales propios.This essay studies the operatic productions made in Spain and France to commemorate the Peace of the Pyrenees and the marriage between the Infanta María Teresa of Austria and Louis XIV of France. On the Spanish side, we analyze La purpura de la rosa (1660), written by Pedro Calderón de la Barca with music by Juan Hidalgo. On the French side, we take into consideration the representations of Xerses (1654, 1660) by Francesco Cavalli and Nicolò Minato and l’Ercole amante (1662) by the Italian composer and Francesco Buti. This comparative study allows us to enter into the opera’s diplomatic uses of both sides of the Pyrenees to construct narratives favorable to their own national interests and inf luence foreign powers’ representatives