The Effect of Atmospheric Pollution on Building Materials in the Urban Environment

Nowadays atmospheric pollution affects not only the urban environment in general, but building materials, which leads to their corrosion, in particular. The article discusses the regularities of the adhesion process of particulate matter (dust) on the vertical surfaces of buildings and structures, which are made of various building materials. On the basis of experimental studies, regression dependences of the adhesion of urban dust on different vertical surfaces from random determining factors were obtained. Thus, by studying the regularities of pollution of urban environment objects, made of various building materials, it is possible to achieve their preservation, since they demonstrate the architectural and design features of various historical periods of the country's development

Development of hybrid reconstruction techniques for TAIGA

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The research of contamination regularities of historical buildings and architectural monuments by methods of computer modeling

Due to the active step of urbanization and rapid development of industry the external appearance of buildings and architectural monuments of urban environment from visual ecology position requires special attention. Dust deposition by polluted atmospheric air is one of the key aspects of degradation of the facades of buildings. With the help of modern computer modeling methods it is possible to evaluate the impact of polluted atmospheric air on the external facades of the buildings in order to save them

The research of contamination regularities of historical buildings and architectural monuments by methods of computer modeling

Due to the active step of urbanization and rapid development of industry the external appearance of buildings and architectural monuments of urban environment from visual ecology position requires special attention. Dust deposition by polluted atmospheric air is one of the key aspects of degradation of the facades of buildings. With the help of modern computer modeling methods it is possible to evaluate the impact of polluted atmospheric air on the external facades of the buildings in order to save them

All - d - Enantiomeric Peptide D3 Designed for Alzheimer’s Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors

Alzheimer’s disease (AD) is a severe neurodegenerative pathology with no effective treatment known. Toxic amyloid-β peptide (Aβ) oligomers play a crucial role in AD pathogenesis. All-d-Enantiomeric peptide D3 and its derivatives were developed to disassemble and destroy cytotoxic Aβ aggregates. One of the D3-like compounds is approaching phase II clinical trials; however, high-resolution details of its disease-preventing or pharmacological actions are not completely clear. We demonstrate that peptide D3 stabilizing Aβ monomer dynamically interacts with the extracellular juxtamembrane region of a membrane-bound fragment of an amyloid precursor protein containing the Aβ sequence. MD simulations based on NMR measurement results suggest that D3 targets the amyloidogenic region, not compromising its α-helicity and preventing intermolecular hydrogen bonding, thus creating prerequisites for inhibition of early steps of Aβ conversion into β-conformation and its toxic oligomerization. An enhanced understanding of the D3 action molecular mechanism facilitates development of effective AD treatment and prevention strategies

How does the break-junction quasiparticle tunnel conductance look like for d-wave superconductors?

The bias-voltage, V, dependences of the differential tunnel conductance G(V) = dJ/DV were calculated for the quasiparticle current J flowing in the ab plane across the break junction made of d-wave superconductors. The tunnel directionality effect was taken into account by introducing an effective tunneling cone described by the angle 2θ₀. It was shown that G(V) looks like predominantly d-wave or isotropic s-wave ones, depending on the magnitude of θ₀ and the rotation angles of the crystal lattices of electrodes with respect to the junction plane. In certain configurations, the G(V) dependences of nominally symmetric S-I-S junctions may turn out similar to those for non-symmetric S–I–N junctions (here, S, I, and N denote superconductors, insulators, and normal metals, respectively) and provide misleading information about the actual energy gap. At finite temperatures, sub-gap structures appear, which possess features appropriate to both d- and s-wave superconductors and are dependent on the problem parameters