Transformation of the national legislation of Ukraine in the context of globalization

The article studies the directions of transformation of the national legislation of Ukraine in the context of globalization based on the dialectical method. Specifically, the notions “legislation” and “globalization” are analyzed; the meaning of the concepts of “national legislation of Ukraine” and “legal globalization” is specified; the factors which define features of transformation of the national legislation of Ukraine in modern conditions of globalization are established. As a result of the study it is proved that the main directions of transformation of the national legislation of Ukraine in the conditions of globalization are the following: borrowing the European (Western) legal tradition and its adaptation to the national legal system of Ukraine; reception of innovative legal institutions while preserving the national legal tradition; the influence of international law, first of all, the Acquis communautaire (adaptation of the national legislation of Ukraine to the law of the European Union); hierarchical (vertical) and sectoral (horizontal) structure of legislation, which is characteristic of the legal systems of the Romano-Germanic legal family; development of such types of normative activity of public authorities as systematization, codification, ordering, unification, etc. &nbsp

Socio-Psychological Criteria of the Formation of Gender Stereotypes of Appearance

The article considers the socio-psychological criteria for the formation of gender stereotypes of appearance. The priority of the study is implementing a system of criteria for gender stereotypes of appearance, taking into account the system of socio-psychological factors and gender-oriented forms of prevention of overcoming sexism and discrimination on the grounds of personality attractiveness. It is substantiated that social evaluation through physical criteria creates several psychological problems because the "physical self" is an essential component of the "self-concept" and one of the criteria of self-esteem. It is proved that the properties of gender stereotypes coincide with the social ones. They are the bearer of emotional and evaluative characteristics, taking into account the group of values associated with the ambivalence of ideas about another. A methodical approach to the assessment of gender stereotypes of appearance and personality is proposed, which allows determining the criteria of human well-being, taking into account discrimination factors, intrapersonal parameters of affective-negative perception of one's appearance and self-concept, as well as the aesthetic perception of identity. An assessment of socio-psychological factors of gender stereotypes of appearance, which is based on the methodological provisions of psychoanalysis and humanism, cognitive paradigm, dispositional theory, cross-cultural approach, and some sociological studies, is carried out. As an experiment on empirical verification of the stereotypes of appearance, their gender differences, and socio-psychological factors, a set of methods of psychological diagnosis is used, which allow determining indicators of stereotypes of appearance, self-esteem, and attitude to beauty; socio-psychological criteria for the formation of gender stereotypes of appearance. A methodology for assessing the criteria for improving the attitude of respondents to their own appearance by determining the level of self-esteem, satisfaction with appearance, awareness of gender differences in appearance, and the desire to improve their own appearance in case of discrimination has been developed and implemented

Devising A Method for Improving the Efficiency of Artillery Shooting Based on the Markov Model

This paper reports a method for improving the firing efficiency of an artillery unit that results in enhanced effectiveness. Given the modern use of artillery for counter-battery warfare, the effectiveness of shooting is not enough assessed by accuracy only. It is also necessary to take into consideration and minimize the time spent by the unit in the firing position and the consumption of shells to hit the target. It has been shown that in order to assess the effectiveness of an artillery shot due to the initial velocity of the projectile, the most rapid and simple means is to classify the quality of the shot by the acoustic field. A procedure for categorizing the shot has been improved by applying an automatic classifier with training based on a machine of support vectors with the least squares. It is established that the error in the classification of the effectiveness of the second shot does not exceed 0.05. The concept of the effectiveness of a single artillery shot was introduced. Under the conditions of intense shooting, there may be accidental disturbances in each shot due to the wear of the charging chamber of the gun, its barrel, and incomplete information about the powder charge. When firing involves disturbances, the firing of an artillery unit can be described by a model of a discrete Markov chain. Based on the Markov model, a method for improving the efficiency of artillery fire has been devised. The method is based on the identification of guns that produce ineffective shots. The fire control phase of the unit has been introduced. In the process of controlling the fire of the unit, such guns are excluded from further firing. A generalized criterion for the effectiveness of artillery firing of a unit, based on the convolution of criteria, has been introduced. It is shown that the devised method significantly improves the effectiveness of shooting according to the generalized criterion

Monogenic Early-Onset Lymphoproliferation and Autoimmunity: The Natural History of STAT3 GOF Syndrome.

Background In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-of-function (GOF) mutations were first described to cause a novel multisystem disease of early-onset lymphoproliferation and autoimmunity. Objective This pivotal cohort study defines the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 GOF variants. Methods We identified 191 patients from 33 countries with 72 unique mutations. Inclusion criteria included symptoms of immune dysregulation and a biochemically confirmed germline heterozygous GOF variant in STAT3. Results Overall survival was 88%, median age at onset of symptoms was 2.3 years, and median age at diagnosis was 12 years. Immune dysregulatory features were present in all patients: lymphoproliferation was the most common manifestation (73%); increased frequencies of double-negative (CD4−CD8−) T cells were found in 83% of patients tested. Autoimmune cytopenias were the second most common clinical manifestation (67%), followed by growth delay, enteropathy, skin disease, pulmonary disease, endocrinopathy, arthritis, autoimmune hepatitis, neurologic disease, vasculopathy, renal disease, and malignancy. Infections were reported in 72% of the cohort. A cellular and humoral immunodeficiency was observed in 37% and 51% of patients, respectively. Clinical symptoms dramatically improved in patients treated with JAK inhibitors, while a variety of other immunomodulatory treatment modalities were less efficacious. Thus far, 23 patients have undergone bone marrow transplantation, with a 62% survival rate. Conclusion : STAT3 GOF patients present with a wide array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisystem autoimmunity. Patient care tends to be siloed, without a clear treatment strategy. Thus, early identification and prompt treatment implementation are lifesaving for STAT3 GOF syndrome. Key word