The cholera epidemic in South Africa, 1980 - 1987 Epidemiological features

During the cholera epidemic in South Africa, 1980-1987, 25251 cases of cholera were bacteriologically proven. The case-fatality rate was 1,4%. Outbreaks occurred in the summer rainfall season. Age-specific aUack rates followed the pattern typically found during the 'epidemic phase' of the disease in most years. The vast majority of patients were black South Africans living in rural areas with an average annual rainfall in excess of 600 mm. The containment strategy employed is summarised. Despite the apparent eradication of the disease, it is strongly recommended that vigilance should be maintained and investigations of all possible sources of infection and all human contacts of any new proven case should be carried out speedily and thoroughly

National HIV surveillance - South Africa, 1990 - 1992

The findings of three annual surveys of women attending antenatal clinics (at the end of 1990,1991 and 1992) are presented here. These surveys form part of the National HIV Surveillance Programme. This programme is probably the most usefulmeans of monitoring the trend and distribution of the epidemic. In all strata, a consistent rise in the HIV prevalence rate was found; it doubled almost every 12 months. The point prevalence rate in antenatal clinic attenders in South Africa increased from 0,76% in 1990 to 1,49% in 1991 and 1,49% in 1992. The prevalence rate was found to vary widely geographically: Natal/KwaZulu formed the spearhead of the epidemic with a 4,77% rate of HIV infection in 1992. Venda and the Capeappeared to be the least affected with rates of 0,64% and 0,66% respectively

VLT/UVES Spectroscopy of Individual Stars in Three Globular Clusters in the Fornax Dwarf Spheroidal Galaxy

We present a high resolution (R ~ 43000) abundance analysis of a total of nine stars in three of the five globular clusters associated with the nearby Fornax dwarf spheroidal galaxy. These three clusters (1, 2 and 3) trace the oldest, most metal-poor stellar populations in Fornax. We determine abundances of O, Mg, Ca, Ti, Cr, Mn, Fe, Ni, Zn, Y, Ba, La, Nd and Eu in most of these stars, and for some stars also Mn and La. We demonstrate that classical indirect methods (isochrone fitting and integrated spectra) of metallicity determination lead to values of [Fe/H] which are 0.3 to 0.5 dex too high, and that this is primarily due to the underlying reference calibration typically used by these studies. We show that Cluster 1, with [Fe /H] = -2.5, now holds the record for the lowest metallicity globular cluster. We also measure an over-abundance of Eu in Cluster 3 stars that has only been previously detected in a subgroup of stars in M15. We find that the Fornax globular cluster properties are a global match to what is found in their Galactic counterparts; including deep mixing abundance patterns in two stars. We conclude that at the epoch of formation of globular clusters both the Milky Way and the Fornax dwarf spheroidal galaxy shared the same initial conditions, presumably pre-enriched by the same processes, with identical nucleosynthesis patterns.Comment: 16 pages, 12 figures. Accepted for publication in A&

Serum big endothelin-1 as a biomarker in oral squamous cell carcinoma patients: an analytical study

Detection of abnormally elevated levels of molecules in patients with oral cancer may be useful in early diagnosis. These markers can be included in current Histopathology grading and in TNM staging systems of Oral Squamous Cell Carcinoma (OSCC) to make it more efficient. Several pro-angiogenic molecules have been assessed for the same reason. Endothelin-1 (ET-1) is a vasoactive peptide associated with the development and spread of many solid tumors, including Squamous Cell Carcinoma (SCC), but its utility in OSCC has not been confirmed. Objective This study aims to evaluate the role of the serum big ET-1 as a biomarker of OSCC, by correlating it with the clinical staging and the histopathological grading. Material and Methods Serum levels of big ET-1 measured by the sandwich Enzyme-Linked Immunosorbent Assay (ELISA) in 40 OSCC cases were compared with the levels from the control group using independent t-test. Clinical stages and histopathological grades of OSCC cases were compared in relation to their mean levels of serum big ET-1, one using the Analysis of Variance (ANOVA) test and the other the independent t-test, respectively. The significance of the mean difference between the groups was evaluated by Tukey&#8217;s multiple comparison test. All statistical analyses were performed on GraphPad statistical software version 5.0. Results By comparing the mean of the big ET-1 concentrations of cases and controls, the independent t-test revealed significant higher big ET-1 concentration of OSCC cases when compared to controls (p<0.0001). Tukey&#8217;s multiple comparison test also revealed statistically significant difference among all OSCC stages in relation to the mean levels of serum big ET-1. However, the mean of the big ET-1 concentrations of cases of grade I and of grade II did not differ statistically (p=0.729). Conclusion Serum big ET-1 levels may be useful as a diagnostic tool in OSCC and as an adjunct to OSCC staging. However, its use as a prognostic marker warrants larger prospective studies