1,077 research outputs found
Nonlinear Dynamics of Composite Plates and Shells
The equations of refined geometrically nonlinear theory of dynamic deformation of flexible with respect to
transversal shear and compression ofplates and shells are proposed. The solutions for problems of transversal
nonlinear vibrations of hinge fixedplate-strip are obtained. Numerical results are compared with the known in
literature
Bi-stochastic kernels via asymmetric affinity functions
In this short letter we present the construction of a bi-stochastic kernel p
for an arbitrary data set X that is derived from an asymmetric affinity
function {\alpha}. The affinity function {\alpha} measures the similarity
between points in X and some reference set Y. Unlike other methods that
construct bi-stochastic kernels via some convergent iteration process or
through solving an optimization problem, the construction presented here is
quite simple. Furthermore, it can be viewed through the lens of out of sample
extensions, making it useful for massive data sets.Comment: 5 pages. v2: Expanded upon the first paragraph of subsection 2.1. v3:
Minor changes and edits. v4: Edited comments and added DO
Anisotropic diffusion on sub-manifolds with application to Earth structure classification
AbstractWe introduce a method to re-parameterize massive high dimensional data, generated by nonlinear mixing, into its independent physical parameters. Our method enables the identification of the original parameters and their extension to new observations without any knowledge of the true physical model. The suggested approach in this paper is related to spectral independent components analysis (ICA) via the construction of an anisotropic diffusion kernel whose eigenfunctions comprise the independent components. However, we use a novel anisotropic diffusion process, utilizing only a small observed subset Y¯, that approximates the isotropic diffusion on the parametric manifold MX of the full set Y. We employ a Nyström-type extension of the independent components of Y¯ to the independent components of Y, and provide a validation scheme for our algorithm parameters choice. We demonstrate our method on synthetic examples and on real application examples
Ryanodine receptor studies using genetically engineered mice
AbstractRyanodine receptors (RyR) regulate intracellular Ca2+ release in many cell types and have been implicated in a number of inherited human diseases. Over the past 15years genetically engineered mouse models have been developed to elucidate the role that RyRs play in physiology and pathophysiology. To date these models have implicated RyRs in fundamental biological processes including excitation–contraction coupling and long term plasticity as well as diseases including malignant hyperthermia, cardiac arrhythmias, heart failure, and seizures. In this review we summarize the RyR mouse models and how they have enhanced our understanding of the RyR channels and their roles in cellular physiology and disease
UK membership(s) in the European Higher Education Area post-2020: a ‘Europeanisation’ agenda
The European Higher Education Area (EHEA) is an international initiative for the harmonisation of higher education (HE) systems in 49 countries. Literature about UK’s participation in the EHEA is limited, and the role of EHEA’s membership for the UK, particularly after the end of the Brexit transitional period, has not been researched. The originality of the study reported in this paper is in addressing this gap by exploring the perspectives of key UK HE actors on the strategic significance of UK’s memberships in the EHEA post-2020 for the UK. The paper draws on the theoretical ideas of rational choice neo-institutionalism, differentiated Europeanisation and internationalisation, and a thematic analysis of 19 official communications of key stakeholders and six in-depth interviews with their representatives. The findings contribute to filling in a significant gap in the literature about Bologna in the UK in making a distinction between its two memberships in the EHEA and the differences and complexities of the roles they play in constructing UK’s overarching agenda in HE particularly in the post-Brexit context. The article has also contributed to the literature about Bologna more widely, presenting an investigation into differentiated Europeanisation that has been taking place within one unique post-EU country
Modeling a Superconducting Triplet Spin Valve with Several Layers of a Superconductor
A matrix solution to Usadel linearized equations is used to obtain the critical temperature and distribution of singlet pairing components of a superconductor/ferromagnetic/superconductor/ferromagnetic structure with nonideal boundaries. There is a transition from the π- to the 0-phase state between the superconductor layers upon varying the angle between the magnetizations of ferromagnetic layers in such a structure.</p
A clinically feasible multiplex proteomic immunoassay as a novel functional diagnostic for pancreatic ductal adenocarcinoma
The mechanical and microstructural behaviour of calcite-dolomite composites: An experimental investigation
Thermodynamic Models for the Temperature and Pressure Variations Within Adiabatic Caverns of Compressed Air Energy Storage Plants
The temperature and pressure variation limits within the cavern of a compressed air energy storage (CAES) plant affect the compressor and turbine works, the required fuel consumption and therefore the overall plant performance. In the present work, the thermodynamic response of adiabatic cavern reservoirs to charge/discharge cycles of CAES plants are studied. Solutions for the air cavern temperature and pressure variations were derived from the mass and energy conservation equations, and applied to three different gas state equations, namely, ideal, real, and a self-developed simplified gas models. Sensitivity analyses were conducted to identify the dominant parameters that affect the storage temperature and pressure fluctuations. It is demonstrated that a simplified gas model can adequately represent the air thermodynamic properties. The stored air maximal to minimal temperature and pressure ratios were found to depend primarily on, both the ratio of the injected to the initial cavern air mass, and the reservoir mean pressure. The results also indicate that the storage volume is highly dependent on the air maximum to minimum pressure ratio. Its value should preferably be in between 1.2 and 1.8, where the exact selection should account for design and economic criteria
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