Use fo Castables and high alumina refractories for lining reheating furnaces

Reheating furnaces are used for intermediate heating of steel blooms, ingots, billets and slabs during their final finishing process. These furnaces are of two types i.e. batch type and continuous type. Batch furnaces are gene-rally simple box type used for heating prior to forging and shaping. Such furnaces should be able to withstand required operating temperature, frequent heating and cool-ing and abrasion due to stock handling

Developments in the production of soderberg paste for electrodes in ferro alloy furnaces

Using raw petroleum coke as raw-material, NML has devel-oped a dense carbon aggregate as a substitute for gas calcined anthracite. This dense carbon aggregate has been used for making soderberg paste, the properties of which have been studied and compared with a Norwegian and two indigenous pastes. The suitability of this material has been tested on a commercial scale in ferro alloy and pig iron furnaces. Attempts also have been made to produce dense carbon aggregate by partial replacement of petroleum coke with low ash coal and the study of its properties have been described in this paper

On the nature of the candidate T-Tauri star V501 Aurigae

We report new multi-colour photometry and high-resolution spectroscopic observations of the long-period variable V501 Aur, previously considered to be a weak-lined T-Tauri star belonging to the Taurus-Auriga star-forming region. The spectroscopic observations reveal that V501 Aur is a single-lined spectroscopic binary system with a 68.8-day orbital period, a slightly eccentric orbit (e ~ 0.03), and a systemic velocity discrepant from the mean of Taurus-Auriga. The photometry shows quasi-periodic variations on a different, ~55-day timescale that we attribute to rotational modulation by spots. No eclipses are seen. The visible object is a rapidly rotating (vsini ~ 25 km/s) early K star, which along with the rotation period implies it must be large (R > 26.3 Rsun), as suggested also by spectroscopic estimates indicating a low surface gravity. The parallax from the Gaia mission and other independent estimates imply a distance much greater than the Taurus-Auriga region, consistent with the giant interpretation. Taken together, this evidence together with a re-evaluation of the LiI~$\lambda$6707 and H$\alpha$ lines shows that V501 Aur is not a T-Tauri star, but is instead a field binary with a giant primary far behind the Taurus-Auriga star-forming region. The large mass function from the spectroscopic orbit and a comparison with stellar evolution models suggest the secondary may be an early-type main-sequence star.Comment: 13 pages, 7 figures. Accepted to MNRA

The path to Z And-type outbursts: The case of V426 Sagittae (HBHA 1704-05)

Context. The star V426 Sge (HBHA 1704-05), originally classified as an emission-line object and a semi-regular variable, brightened at the beginning of August 2018, showing signatures of a symbiotic star outburst. Aims. We aim to confirm the nature of V426 Sge as a classical symbiotic star, determine the photometric ephemeris of the light minima, and suggest the path from its 1968 symbiotic nova outburst to the following 2018 Z And-type outburst. Methods. We re-constructed an historical light curve (LC) of V426 Sge from approximately the year 1900, and used original low- (R ∼ 500-1500; 330-880 nm) and high-resolution (R ∼ 11 000-34 000; 360-760 nm) spectroscopy complemented with Swift-XRT and UVOT, optical UBVRCIC and near-infrared JHKL photometry obtained during the 2018 outburst and the following quiescence. Results. The historical LC reveals no symbiotic-like activity from ∼1900 to 1967. In 1968, V426 Sge experienced a symbiotic nova outburst that ceased around 1990. From approximately 1972, a wave-like orbitally related variation with a period of 493.4 ± 0.7 days developed in the LC. This was interrupted by a Z And-type outburst from the beginning of August 2018 to the middle of February 2019. At the maximum of the 2018 outburst, the burning white dwarf (WD) increased its temperature to ? 2 × 105 K, generated a luminosity of ∼7 × 1037 (d/3.3 kpc)2 erg s-1 and blew a wind at the rate of ∼3 × 10-6 M yr-1. Our spectral energy distribution models from the current quiescent phase reveal that the donor is a normal M4-5 III giant characterised with Teff ∼ 3400 K, RG ∼ 106 (d/3.3 kpc) R and LG ∼ 1350 (d/3.3 kpc)2 L and the accretor is a low-mass ∼0.5 M WD. Conclusions. During the transition from the symbiotic nova outburst to the quiescent phase, a pronounced sinusoidal variation along the orbit develops in the LC of most symbiotic novae. The following eventual outburst is of Z And-type, when the accretion by the WD temporarily exceeds the upper limit of the stable burning. At this point the system becomes a classical symbiotic star.Fil: Skopal, A.. Astronomical Institute Slovak Academy Of Sciences; EslovaquiaFil: Shugarov, S. Y.. Lomonosov Moscow State University; Rusia. Astronomical Institute Slovak Academy Of Sciences; EslovaquiaFil: Munari, U.. Osservatorio Astronomico Di Padova; ItaliaFil: Masetti, N.. Inaf Istituto Di Astrofisica Spaziale E Fisica Cosmica, Bologna; Italia. Universidad Andrés Bello; ChileFil: Marchesini, Ezequiel Joaquín. Università di Torino; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Komzík, R. M.. Astronomical Institute Slovak Academy Of Sciences; EslovaquiaFil: Kundra, E.. Astronomical Institute Slovak Academy Of Sciences; EslovaquiaFil: Shagatova, N.. Astronomical Institute Slovak Academy Of Sciences; EslovaquiaFil: Tarasova, T. N.. Crimean Astrophysical Observatory Ras; RusiaFil: Buil, C.. Castanet Tolosan Observatory; FranciaFil: Boussin, C.. Observatoire de L'eridan Et de la Chevelure de Bérénice; FranciaFil: Shenavrin, V. I.. Lomonosov Moscow State University; RusiaFil: Hambsch, F. J.. Istituto Nazionale di Astrofisica; ItaliaFil: Dallaporta, S.. Istituto Nazionale di Astrofisica; ItaliaFil: Frigolé, Cecilia Andrea. Istituto Nazionale di Astrofisica; ItaliaFil: Gardey, Juan Cruz. Observatoire de la Tourbière; FranciaFil: Zubareva, A.. Institute Of Astronomy Of The Russian Academy Of Sciences; Rusia. Lomonosov Moscow State University; RusiaFil: Dubovský, P. A.. Vihorlat Observatory; EslovaquiaFil: Kroll, P.. Sonneberg Observatory; Alemani

The MD Anderson prostate cancer patient-derived xenograft series (MDA PCa PDX) captures the molecular landscape of prostate cancer and facilitates marker-driven therapy development

BACKGROUND: Advances in prostate cancer (PCa) lag behind other tumor types partly due to the paucity of models reflecting key milestones in PCa progression. OBJECTIVE: To develop clinically relevant PCa models. DESIGN: Since 1996 we have generated clinically annotated patient-derived xenografts (PDXs) (the MDA PCa PDX series) linked to specific phenotypes reflecting all aspects of clinical PCa. RESULTS: We studied two cell line-derived xenografts and the first 80 PDXs derived from 47 human PCa donors. Of these, 47 PDXs derived from 22 donors are working models and can be expanded either as cell lines (MDA PCa 2a and 2b) or PDXs. The histopathologic, genomic, and molecular characteristics (AR, ERG, and PTEN loss) maintain fidelity with the human tumor and correlate with published findings. PDX growth response to mouse castration and targeted therapy illustrate their clinical utility. Comparative genomic hybridization and sequencing show significant differences in oncogenic pathways in pairs of PDXs derived from different areas of the same tumor. We also identified a recurrent focal deletion in an area that includes the SPOPL gene in PDXs derived from 7 human donors out of 28 studied (25%). SPOPL is a SPOP paralog, and SPOP mutations define a molecular subclass of PCa. SPOPL deletions are found in 7% of TCGA PCas, which suggests that our cohort is a reliable platform for targeted drug development. CONCLUSIONS: The MDA PCa PDX series is a dynamic resource that captures the molecular landscape of PCas progressing under novel treatments and enables optimization of PCa-specific, marker-driven therapy

Long-term photometry of IC 348 with the Young Exoplanet Transit Initiative network

We present long-term photometric observations of the young open cluster IC 348 with a baseline time-scale of 2.4 yr. Our study was conducted with several telescopes from the Young Exoplanet Transit Initiative (YETI) network in the Bessel R band to find periodic variability of young stars. We identified 87 stars in IC 348 to be periodically variable; 33 of them were unreported before. Additionally, we detected 61 periodic non-members of which 41 are new discoveries. Our wide field of view was the key to those numerous newly found variable stars. The distribution of rotation periods in IC 348 has always been of special interest. We investigate it further with our newly detected periods but we cannot find a statistically significant bimodality. We also report the detection of a close eclipsing binary in IC 348 composed of a low-mass stellar component (M ≳ 0.09 M⊙) and a K0 pre-main-sequence star (M ≈ 2.7 M⊙). Furthermore, we discovered three detached binaries among the background stars in our field of view and confirmed the period of a fourth one

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Modelling the spectral energy distribution of the red giant in RS Ophiuchi: Evidence for irradiation

We present an analysis of optical and infrared spectra of the recurrent nova RS Oph obtained during between 2006 and 2009. The best fit to the optical spectrum for 2006 September 28 gives Teff = 3900 K for log g = 2.0, while for log g = 0.0 we find Teff = 4700 K, and a comparison with template stellar spectra provides Teff ~ 4500 K. The observed spectral energy distribution (SED), and the intensities of the emission lines, vary on short (≲1 d) time-scales, due to disc variability. We invoke a simple one-component model for the accretion disc, and a model with a hot boundary layer, with high (~3.9 × 10-6M⊙ yr-1) and low (~2 × 10-8M⊙ yr-1) accretion rates, respectively. Fits to the accretion disc-extracted infrared spectrum (2008 July 15) yield effective temperatures for the red giant of Teff = 3800 ± 100 K (log g = 2.0) and Teff = 3700 ± 100 K (log g = 0.0). Furthermore, using a more sophisticated approach, we reproduced the optical and infrared SEDs of the red giant in the RS Oph system with a twocomponent model atmosphere, in which 90 per cent of the surface has Teff = 3600 K and 10 per cent has Teff = 5000 K. Such structure could be due to irradiation of the red giant by the white dwarf. © 2015 The Authors

Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series

PURPOSE: Develop and deploy a robust discovery platform that encompasses heterogeneity, clinical annotation, and molecular characterization and overcomes the limited availability of prostate cancer models. This initiative builds on the rich MD Anderson (MDA) prostate cancer (PCa) patient-derived xenograft (PDX) resource to complement existing publicly available databases by addressing gaps in clinically annotated models reflecting the heterogeneity of potentially lethal and lethal prostate cancer. EXPERIMENTAL DESIGN: We performed whole-genome, targeted, and RNA sequencing in representative samples of the same tumor from 44 PDXs derived from 38 patients linked to donor tumor metadata and corresponding organoids. The cohort includes models derived from different morphologic groups, disease states, and involved organ sites (including circulating tumor cells), as well as paired samples representing heterogeneity or stages before and after therapy. RESULTS: The cohort recapitulates clinically reported alterations in prostate cancer genes, providing a data resource for clinical and molecular interrogation of suitable experimental models. Paired samples displayed conserved molecular alteration profiles, suggesting the relevance of other regulatory mechanisms (e.g., epigenomic) influenced by the microenvironment and/or treatment. Transcriptomically, models were grouped on the basis of morphologic classification. DNA damage response-associated mechanisms emerged as differentially regulated between adenocarcinoma and neuroendocrine prostate cancer in a cross-interrogation of PDX/patient datasets. CONCLUSIONS: We addressed the gap in clinically relevant prostate cancer models through comprehensive molecular characterization of MDA PCa PDXs, providing a discovery platform that integrates with patient data and benchmarked to therapeutically relevant consensus clinical groupings. This unique resource supports robust hypothesis generation and testing from basic, translational, and clinical perspectives