Phytotherapy of cyclic mastalgia in patients with diffuse mastopathy and premenstrual syndrome

Research objective. To carry out the overview of the published works devoted to assessment of efficiency and safety of the phytodrug  mastodynon, which includes Vitexagnus-castus extract, in treatment of mastalgia caused by a benign dysplasia of mammary glands  and/or a premenstrual syndrome, with the analysis of use of the obtained data in clinical practice of obstetrician-gynecologist. Materials and methods. The foreign and domestic articles which are selected in Pubmed, eLIBRARY according to keywords «cyclic  mastalgia», «diffusion benign dysplasia of mammary glands», «premenstrual syndrome», «hyperprolactinemia», «Vitexagnus-castus»,  «mastodynon» are used. The results of the analysed clinical trials demonstrate efficiency of phytodrugs in treatment of mastalgia in  patients with various forms of diffusion mastopathy and premenstrual syndrome.Conclusion. Mastodynon can be recommended as  effective and safe first-choice drug for treatment of a cyclic mastalgia in patients with a diffusion benign dysplasia of mammary  glands and a premenstrual syndrome

FORAMINIFERAL ZONAL STANDARD FOR THE LOWER CARBONIFEROUSOF RUSSIA AND ITS CORRELATION WITH THE CONODONT ZONATION

This paper describes the zonal subdivisions of the revised Foraminiferal Scale of Russia and their correlation to conodont zones and age-equivalent beds in Western Europe and North America. The foraminiferal zonal sequence is documented in key sections and wells that cover the entire Lower Carboniferous. Boundary reference sections are proposed for most Tournaisian and Serpukhovian zones. Major evolutionary trends within the foraminifers are used to define individual zones.&nbsp

Information technologies in teaching humanitarian disciplines

The use of information technology in teaching humanitarian disciplines contributes to the formation of highly qualified, competitive specialists who can adapt to rapidly changing conditions, possessing a high level of development of critical and creative thinking, ready for professional self-development and self-improvement, for the implementation of reflection, capable of setting goals and systematically achieving them. The work actualizes the importance of information technology in the training of highly qualified competitive specialists capable of implementing professional activities at a high level. The purpose of the article is to analyze the experience of implementing information technologies in teaching humanitarian disciplines. Smart boards, multimedia installations, document cameras, electronic textbooks, electronic educational platforms and others were used as information technologies used in the teaching of the humanities. The study made it possible to reveal the influence of information technologies on the level of formation of students' competencies

Disposal of Used Petroleum Products and Conditioning of Waste Water Based on Cavitation Technology in Circumpolar Territories

Проблема интенсивного освоения богатств Сибири и Севера стала принципиально актуальной для России в связи с исчерпанием основных разведанных запасов природных ресурсов в ее европейской части. Ускоренное освоение Севера и Арктики, включая побережье и шельф арктических морей, направленное на усиление экономического потенциала России, означает развитие базовых отраслей промышленности (горнодобывающей, нефтяной и газовой) с созданием соответствующей инфраструктуры. По статистике, только около 0,3 % мировых водных ресурсов можно получить из рек, озер или доступных ресурсов подземных вод. Быстрый рост индустриализации, особенно в некоторых частях Азии, приводит к сильному загрязнению рек и водоносных горизонтов из-за нерационального использования имеющихся ресурсов. Благодаря быстрому развитию водного транспорта и интенсивной эксплуатации запасов жидких углеводородов, таких как нефть, растет количество аварий и ЧС, инициирующих загрязнение открытых водоемов. Особенно высок эколого-экономический ущерб от разливов нефтепродуктов во внутренних реках, из-за их особого географического положения и крайней токсичности смеси углеводородов. В связи с этим на первый план выходит задача обеспечения техногенной, экологической и энергетической безопасности сложных технических объектов и циркумполярных регионов в целом. Особую важность приобретает рациональное и экономное расходование нефтепродуктов. Это относится в том числе и ко всем известным видам масел: моторным, индустриальным, компрессорным, трансформаторным, турбинным и другим. Отработанные масла, попадающие в окружающую природную среду, лишь частично удаляются или обезвреживаются в результате природных процессов. Основная их часть является источником загрязнения почв, грунтов, водных объектов и атмосферного воздуха и приводит к нарушению воспроизводства птиц, рыб, млекопитающих, оказывает вредное воздействие на человека. Основной задачей данного исследования, направленного на снижение экологического воздействия на природную окружающую среду промышленных предприятий, является утилизация и переработка всех видов отходов основного производства. Показано, что эффективность утилизации отработанных масел и других нефтепродуктов в условиях Крайнего Севера с учетом защиты окружающей среды требует дифференцированного подхода к проблеме с учётом особенностей климата и доступности арктических территорий, а также использованием кавитационной технологииThe problem of intensive development of the riches of Siberia and the North has become fundamentally relevant for Russia due to the depletion of the main explored reserves of natural resources in its European part. Accelerated development of the North and the Arctic, including the coast and shelf of the Arctic seas, aimed at strengthening the economic potential of Russia, means the development of basic industries (mining, oil and gas) with the creation of appropriate infrastructure. According to statistics, only about 0.3 % of the world’s water resources can be obtained from rivers, lakes or available groundwater resources. Rapid growth in industrialization, especially in parts of Asia, is leading to severe pollution of rivers and aquifers due to unsustainable use of available resources. Thanks to the rapid development of water transport and intensive exploitation of liquid hydrocarbon reserves such as oil, the number of accidents and emergencies that initiate pollution of open water bodies is growing. The environmental and economic damage from oil spills in inland rivers is especially high due to their special geographical location and the extreme toxicity of the mixture of hydrocarbons. In this regard, the task of ensuring technogenic, environmental and energy safety of complex technical facilities and circumpolar regions as a whole comes to the fore. The rational and economical use of petroleum products is of particular importance. This applies, among other things, to all known types of oils: motor, industrial, compressor, transformer, turbine and others. Waste oils entering the natural environment are only partially removed or rendered harmless as a result of natural processes. The main part of them is a source of pollution of soils, soils, water bodies and atmospheric air, and leads to disruption of the reproduction of birds, fish, mammals, and has a harmful effect on humans. The main objective of this study, aimed at reducing the environmental impact of industrial enterprises on the natural environment, is the disposal and recycling of all types of waste from primary production. It is shown that the efficiency of recycling waste oils and other petroleum products in the Far North, taking into account environmental protection, requires a differentiated approach to the problem, taking into account the climate and accessibility of Arctic territories, as well as the use of cavitation technolog

Monolithic and hybrid integration of InAs/GaAs quantum dot microdisk lasers on silicon

A method of hybrid integration of quantum dot microdisk lasers with silicon wafer is proposed and realized. In addition to the possibility of combining microlasers with various silicon-based electronic and photonic devices, this makes it possible to significantly improve heat removal from the active region of the microlaser. The thermal resistance normalized to the mesa area reaches the level of about 0.002 (K/W)*cm2, which is significantly lower than the corresponding values of QD microlasers on GaAs substrate and monolithically grown on Si. As a result, the threshold current as well as current-induced shift of emission wavelength are reduced in continuous-wave regime

Проект организации ремонтной мастерской в условиях компании "Сандайское коллективное сельхозпредприятие" п. Тяжин, Кемеровской области

Анотация В обеспечении успешной деятельности хозяйств, важная роль принадлежит их ремонтной службе. Сельское хозяйство страны располагает развитой системой ремонтно-обслуживающих предприятий и мастерских хозяйств, пунктов технического обслуживания машин. Однако перед сельским хозяйством стоят серьезные задачи по совершенствованию инженерной службы на селе. Страна ещё несет большие потери из-за выхода машин из строя, их невысокого ресурса, невысокого качества ремонта и технического обслуживания. Существенным обстоятельством, действующим в пользу развития собственных ремонтных мастерских хозяйств, является возможность выполнения определенного объема ремонтных работ в осенне-зимний период силами работников хозяйств, не занятых сельскохозяйственными работами. Это повышает занятость в хозяйствеAnnotation In ensuring the success of the economy, an important role belongs to their repair service. The country's agriculture has developed a system repair and service enterprises and workshops farms, settlements maintenance of machinery. However, before agriculture faces serious challenges in improving the engineering service in rural areas. The country still suffers great losses because of the failure of the machines, their low resources, poor quality of repair and maintenance. An important fact, acting in favor of the development of their own repair shops farms, is the ability to perform a certain amount of repair work in the autumn-winter period the forces of farm workers are not engaged in agricultural work. This increases employment in the sector of workers and contributes to the stabilization frames

Discovery of a novel non-narcotic analgesic derived from the CL-20 explosive: Synthesis, pharmacology, and target identification of thiowurtzine, a potent inhibitor of the opioid receptors and the ion channels

The number of candidate molecules for new non-narcotic analgesics is extremely limited. Here, we report the identification of thiowurtzine, a new potent analgesic molecule with promising application in chronic pain treatment. We describe the chemical synthesis of this unique compound derived from the hexaazaisowurtzitane (CL-20) explosive molecule. Then, we use animal experiments to assess its analgesic activity in vivo upon chemical, thermal, and mechanical exposures, compared to the effect of several reference drugs. Finally, we investigate the potential receptors of thiowurtzine in order to better understand its complex mechanism of action. We use docking, molecular modeling, and molecular dynamics simulations to identify and characterize the potential targets of the drug and confirm the results of the animal experiments. Our findings finally indicate that thiowurtzine may have a complex mechanism of action by essentially targeting the mu opioid receptor, the TRPA1 ion channel, and the Cav voltage-gated calcium channel