High-mobility compensated semimetals, orbital magnetization, and umklapp scattering in bilayer graphene moire superlattices

Twist-controlled moire superlattices (MS) have emerged as a versatile platform in which to realize artificial systems with complex electronic spectra. Bernal-stacked bilayer graphene (BLG) and hexagonal boron nitride (hBN) form an interesting example of the MS that has recently featured a set of unexpected behaviors, such as unconventional ferroelectricity and electronic ratchet effect. Yet, the understanding of the BLG/hBN MS electronic properties has, at present, remained fairly limited. Here we develop a multi-messenger approach that combines standard magnetotransport techniques with low-energy sub-THz excitation to get insights into the properties of this MS. We show that BLG/hBN lattice alignment results in the emergence of compensated semimetals at some integer fillings of the moire bands separated by van Hove singularities where Lifshitz transition occurs. A particularly pronounced semimetal develops when 8 electrons reside in the moire unit cell, where coexisting high-mobility electron and hole systems feature a strong magnetoresistance reaching 2350 % already at B=0.25 T. Next, by measuring the THz-driven Nernst effect in remote bands, we observe valley splitting, pointing to an orbital magnetization characterized by a strongly enhanced effective g-factor of 340. Last, using THz photoresistance measurements, we show that the high-temperature conductivity of the BLG/hBN MS is limited by electron-electron umklapp processes. Our multi-facet analysis introduces THz-driven magnetotransport as a convenient tool to probe the band structure and interaction effects in vdW materials and provides a comprehension of the BLG/hBN MS

International Effort Helps Decipher Mysteries of Paleoclimate From Antarctic Ice Cores

International audienceIce cores drilled at Vostok Station, Antarctica, and studied over the past 10 years by Russia, France, and the United States (Figure 1) are providing a wealth of information about past climate and environmental changes over more than a full glacial-interglacial cycle. The ice cores show that East Antarctica was colder and drier during glacial periods than during the Holocene and that large-scale atmospheric circulation was more vigorous during glacial times. They also support evidence from deep-sea sediment studies favoring orbital forcing of Pleistocene climate, reveal direct correlations of carbon dioxide and methane concentrations with temperature, and indicate how the accumulation of trace compounds have changed through time

International Effort Helps Decipher Mysteries of Paleoclimate from Antarctic Ice Cores

Ice cores drilled at Vostok Station, Antarctica, and studied over the past 10 years by Russia, France, and the United States (Figure 1) are providing a wealth of information about past climate and environmental changes over more than a full glacial-interglacial cycle. The ice cores show that East Antarctica was colder and drier during glacial periods than during the Holocene and that large-scale atmospheric circulation was more vigorous during glacial times. They also support evidence from deep-sea sediment studies favoring orbital forcing of Pleistocene climate, reveal direct correlations of carbon dioxide and methane concentrations with temperature, and indicate how the accumulation of trace compounds have changed through time

Management of patients with multidrug-resistant tuberculosis

Funding Information: JH and CL are supported by the German Center for Infection Research (DZIF). TS is supported by The Swedish Heart and Lung Foundation and the Swedish Research Council. KD is supported by the South African Medical Research Council and the European Union (EDCTP) Publisher Copyright: © 2019 The Union.The emergence of multidrug-resistant tuberculosis (MDR-TB; defined as resistance to at least rifampicin and isoniazid) represents a growing threat to public health and economic growth. Never before in the history of mankind have more patients been affected by MDRTB than is the case today. The World Health Organization reports that MDR-TB outcomes are poor despite staggeringly high management costs. Moreover, treatment is prolonged, adverse events are common, and the majority of affected patients do not receive adequate treatment. As MDR-TB strains are often resistant to one or more second-line anti-TB drugs, in-depth genotypic and phenotypic drug susceptibility testing is needed to construct personalised treatment regimens to improve treatment outcomes. For the first time in decades, the availability of novel drugs such as bedaquiline allow us to design potent and well-tolerated personalised MDR-TB treatment regimens based solely on oral drugs. In this article, we present management guidance to optimise the diagnosis, algorithm-based treatment, drug dosing and therapeutic drug monitoring, and the management of adverse events and comorbidities, associated with MDRTB. We also discuss the role of surgery, physiotherapy, rehabilitation, palliative care and smoking cessation in patients with MDR-TB. We hope that incorporating these recommendations into patient care will be helpful in optimising treatment outcomes, and lead to more MDRTB patients achieving a relapse-free cure.publishersversionPeer reviewe