7,321 research outputs found
Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders.
The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social behavior. The present study was carried out to compare two commonly used strains of laboratory rats, Sprague-Dawley (SD) and Long-Evans (LE), between the ages of postnatal day (PND) 26-56 using high-throughput behavioral phenotyping tools commonly used in mouse models of ASD that we have adapted for use in rats. We detected few differences between young SD and LE strains on standard assays of exploration, sensorimotor gating, anxiety, repetitive behaviors, and learning. Both SD and LE strains also demonstrated sociability in the 3-chamber social approach test as indexed by spending more time in the social chamber with a constrained age/strain/sex matched novel partner than in an identical chamber without a partner. Pronounced differences between the two strains were, however, detected when the rats were allowed to freely interact with a novel partner in the social dyad paradigm. The SD rats in this particular testing paradigm engaged in play more frequently and for longer durations than the LE rats at both juvenile and young adult developmental time points. Results from this study that are particularly relevant for developing preclinical ASD models in rats are threefold: (i) commonly utilized strains exhibit unique patterns of social interactions, including strain-specific play behaviors, (ii) the testing environment may profoundly influence the expression of strain-specific social behavior and (iii) simple, automated measures of sociability may not capture the complexities of rat social interactions
Plasmonic backscattering enhanced inverted photovoltaics
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98669/1/ApplPhysLett_99_113306.pd
Riemann-Hilbert problems for monogenic functions in axially symmetric domains
We consider Riemann-Hilbert boundary value problems (for short RHBVPs) with variable coefficients for axially symmetric monogenic functions defined in axial symmetric domains. This is done by constructing a method to reduce the RHBVPs for axially symmetric monogenic functions defined in four-dimensional axial symmetric domains into the RHBVPs for analytic functions defined over the complex plane. Then we derive solutions to the corresponding Schwarz problem. Finally, we generalize the results obtained to null-solutions of (D−α)ϕ=0, α∈R, where R denotes the field of real numbers
CP^n, or, entanglement illustrated
We show that many topological and geometrical properties of complex
projective space can be understood just by looking at a suitably constructed
picture. The idea is to view CP^n as a set of flat tori parametrized by the
positive octant of a round sphere. We pay particular attention to submanifolds
of constant entanglement in CP^3 and give a few new results concerning them.Comment: 28 pages, 9 figure
Electron-hole and plasmon excitations in 3d transition metals: Ab initio calculations and inelastic x-ray scattering measurements
We report extensive all-electron time-dependent density-functional
calculations and nonresonant inelastic x-ray scattering measurements of the
dynamical structure factor of 3d transition metals. For small wave vectors, a
plasmon peak is observed which is well described by our calculations. At large
wave vectors, both theory and experiment exhibit characteristic low-energy
electron-hole excitations of d character which correlate with the presence of d
bands below and above the Fermi level. Our calculations, which have been
carried out in the random-phase and adiabatic local-density approximations, are
found to be in remarkable agreement with the measured dynamical structure
factor of Sc and Cr at energies below the semicore onset energy (M-edge) of
these materials.Comment: To appear in Phys. Rev.
Unusual photoemission resonances of oxygen-dopant induced states in BiSrCaCuO
We have performed an angular-resolved photoemission study of underdoped,
optimally doped and overdoped BiSrCaCuO samples using a
wide photon energy range (15 - 100 eV). We report a small and broad
non-dispersive A peak in the energy distribution curves whose intensity
scales with doping. We attribute it to a local impurity state similar to the
one observed recently by scanning tunneling spectroscopy and identified as the
oxygen dopants. Detailed analysis of the resonance profile and comparison with
the single-layered BiSrCuO suggest a mixing of this local
state with Cu via the apical oxygens.Comment: 4 pages, 4 figure
Rabi oscillations of a qubit coupled to a two-level system
The problem of Rabi oscillations in a qubit coupled to a fluctuator and in
contact with a heath bath is considered. A scheme is developed for taking into
account both phase and energy relaxation in a phenomenological way, while
taking full account of the quantum dynamics of the four-level system subject to
a driving AC field. Significant suppression of the Rabi oscillations is found
when the qubit and fluctuator are close to resonance. The effect of the
fluctuator state on the read-out signal is discussed. This effect is shown to
modify the observed signal significantly. This may be relevant to recent
experiments by Simmonds et al. [Phys. Rev. Lett. 93, 077003 (2004)].Comment: 4 pages, 4 figure
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