166 research outputs found
Feature Relevance Assessment Of Multispectral Airborne Lidar Data For Tree Species Classification
Abstract. The presented experiment investigates the potential of Multispectral Laser Scanning (MLS) point clouds for single tree species classification. The basic idea is to simulate a MLS sensor by combining two different Lidar sensors providing three different wavelngthes. The available data were acquired in the summer 2016 at the same date in a leaf-on condition with an average point density of 37 points/m2. For the purpose of classification, we segmented the combined 3D point clouds consisiting of three different spectral channels into 3D clusters using Normalized Cut segmentation approach. Then, we extracted four group of features from the 3D point cloud space. Once a varity of features has been extracted, we applied forward stepwise feature selection in order to reduce the number of irrelevant or redundant features. For the classification, we used multinomial logestic regression with L1 regularization. Our study is conducted using 586 ground measured single trees from 20 sample plots in the Bavarian Forest National Park, in Germany. Due to lack of reference data for some rare species, we focused on four classes of species. The results show an improvement between 4–10 pp for the tree species classification by using MLS data in comparison to a single wavelength based approach. A cross validated (15-fold) accuracy of 0.75 can be achieved when all feature sets from three different spectral channels are used. Our results cleary indicates that the use of MLS point clouds has great potential to improve detailed forest species mapping.
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Magnetic excitations in the spin-1 anisotropic antiferromagnet
The spin-1 anisotropic antiferromagnet NiCl_2-4SC(NH2)_2 exhibits a
field-induced quantum phase transition that is formally analogous to
Bose-Einstein condensation. Here we present results of systematic high-field
electron spin resonance (ESR) experimental and theoretical studies of this
compound with a special emphasis on single-ion two-magnon bound states. In
order to clarify some remaining discrepancies between theory and experiment,
the frequency-field dependence of magnetic excitations in this material is
reanalyzed. In particular, a more comprehensive interpretation of the
experimental signature of single-ion two-magnon bound states is shown to be
fully consistent with theoretical results. We also clarify the structure of the
ESR spectrum in the so-called intermediate phase.Comment: 9 pages, 10 figure
Field-induced structural evolution in the spin-Peierls compound CuGeO: high-field ESR study
The dimerized-incommensurate phase transition in the spin-Peierls compound
CuGeO is probed using multifrequency high-resolution electron spin
resonance (ESR) technique, in magnetic fields up to 17 T. A field-induced
development of the soliton-like incommensurate superstructure is clearly
indicated as a pronounced increase of the ESR linewidth (magnon
excitations), with a at 13.8 T. The anomaly is
explained in terms of the magnon-soliton scattering, and suggests that the
soliton-like phase exists close to the boundary of the dimerized-incommensurate
phase transition. In addition, magnetic excitation spectra in 0.8% Si-doped
CuGeO are studied. Suppression of the anomaly observed in the
doped samples suggests a collapse of the long-range-ordered soliton states upon
doping, that is consistent with high-field neutron scattering experiments.Comment: Accepted to Phys. Rev.
High field magnetic resonant properties of beta'-(ET)2SF5CF2SO3
A systematic electron spin resonance (ESR) investigation of the low
temperature regime for the (ET)2SF5CF2SO3 system was performed in the frequency
range of ~200-700 GHz, using backward wave oscillator sources, and at fields up
to 25 T. Newly acquired access to the high frequency and fields shows
experimental ESR results in agreement with the nuclear magnetic resonance (NMR)
investigation, revealing evidence that the transition seen at 20 K is not of
conventional spin-Peierls order. A significant change of the spin resonance
spectrum in beta'-(ET)2SF5CF2SO3 at low temperatures, indicates a transition
into a three-dimensional-antiferromagnetic (3D AFM) phase.Comment: 4 pages, 7 figures, minor grammatical change
Oral chondroitin sulfate and prebiotics for the treatment of canine Inflammatory Bowel Disease: a randomized, controlled clinical trial
BACKGROUND
Canine inflammatory bowel disease (IBD) is a chronic enteropathy of unknown etiology, although microbiome dysbiosis, genetic susceptibility, and dietary and/or environmental factors are hypothesized to be involved in its pathogenesis. Since some of the current therapies are associated with severe side effects, novel therapeutic modalities are needed. A new oral supplement for long-term management of canine IBD containing chondroitin sulfate (CS) and prebiotics (resistant starch, β-glucans and mannaoligosaccharides) was developed to target intestinal inflammation and oxidative stress, and restore normobiosis, without exhibiting any side effects. This double-blinded, randomized, placebo-controlled trial in dogs with IBD aims to evaluate the effects of 180 days administration of this supplement together with a hydrolyzed diet on clinical signs, intestinal histology, gut microbiota, and serum biomarkers of inflammation and oxidative stress.
RESULTS
Twenty-seven client-owned biopsy-confirmed IBD dogs were included in the study, switched to the same hydrolyzed diet and classified into one of two groups: supplement and placebo. Initially, there were no significant differences between groups (p > 0.05) for any of the studied parameters. Final data analysis (supplement: n = 9; placebo: n = 10) showed a significant decrease in canine IBD activity index (CIBDAI) score in both groups after treatment (p < 0.001). After treatment, a significant decrease (1.53-fold; p < 0.01) in histologic score was seen only in the supplement group. When groups were compared, the supplement group showed significantly higher serum cholesterol (p < 0.05) and paraoxonase-1 (PON1) levels after 60 days of treatment (p < 0.01), and the placebo group showed significantly reduced serum total antioxidant capacity (TAC) levels after 120 days (p < 0.05). No significant differences were found between groups at any time point for CIBDAI, WSAVA histologic score and fecal microbiota evaluated by PCR-restriction fragment length polymorphism (PCR-RFLP). No side effects were reported in any group.
CONCLUSIONS
The combined administration of the supplement with hydrolyzed diet over 180 days was safe and induced improvements in selected serum biomarkers, possibly suggesting a reduction in disease activity. This study was likely underpowered, therefore larger studies are warranted in order to demonstrate a supplemental effect to dietary treatment of this supplement on intestinal histology and CIBDAI
Tumor location determines midkine level and its association with the disease progression in colorectal cancer patients: a pilot study
Radar vision in the mapping of forest biodiversity from space
Recent progress in remote sensing provides much-needed, large-scale spatio-temporal information on habitat structures important for biodiversity conservation. Here we examine the potential of a newly launched satellite-borne radar system (Sentinel-1) to map the biodiversity of twelve taxa across five temperate forest regions in central Europe. We show that the sensitivity of radar to habitat structure is similar to that of airborne laser scanning (ALS), the current gold standard in the measurement of forest structure. Our models of different facets of biodiversity reveal that radar performs as well as ALS; median R² over twelve taxa by ALS and radar are 0.51 and 0.57 respectively for the first non-metric multidimensional scaling axes representing assemblage composition. We further demonstrate the promising predictive ability of radar-derived data with external validation based on the species composition of birds and saproxylic beetles. Establishing new area-wide biodiversity monitoring by remote sensing will require the coupling of radar data to stratified and standardized collected local species data
Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic
The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European centers before and during the pandemic. A multicenter, multinational observational registry was created, comparing admissions to the emergency departments during a 3-months period in 2020 (during the pandemic) with the corresponding period in 2019 (pre-pandemic). Data on patient demographics, COVID-19 test results, primary diagnosis, comorbidities, heart failure profile, medication use, and laboratory results were collected. A total of 8778 patients were included in the analysis, with 4447 patients in 2019 and 4331 patients in 2020. The results showed significant differences in the distribution of cardiovascular diseases between the two years. The frequency of pulmonary embolism (PE) increased in 2020 compared to 2019, while acute heart failure (AHF) and other cardiovascular diseases decreased. The odds of PE incidence among hospitalized patients in 2020 were 1.316-fold greater than in 2019. The incidence of AHF was 50.83% less likely to be observed in 2020, and the odds for other cardiovascular diseases increased by 17.42% between the 2 years. Regarding acute coronary syndrome (ACS), the distribution of its types differed between 2019 and 2020, with an increase in the odds of ST-segment elevation myocardial infarction (STEMI) in 2020. Stratification based on sex revealed further insights. Among men, the incidence of AHF decreased in 2020, while other cardiovascular diseases increased. In women, only the incidence of STEMI showed a significant increase. When analyzing the influence of SARS-CoV-2 infection, COVID-positive patients had a higher incidence of PE compared to COVID-negative patients. COVID-positive patients with ACS also exhibited symptoms of heart failure more frequently than COVID-negative patients. These findings provide valuable information on the impact of the COVID-19 pandemic on acute cardiovascular hospital admissions. The increased incidence of PE and changes in the distribution of other cardiovascular diseases highlight the importance of monitoring and managing cardiovascular health during and post pandemic period. The differences observed between sexes emphasize the need for further research to understand potential sex-specific effects of COVID-19 on cardiovascular outcomes
Evolutionary Dynamics of Co-Segregating Gene Clusters Associated with Complex Diseases
BACKGROUND: The distribution of human disease-associated mutations is not random across the human genome. Despite the fact that natural selection continually removes disease-associated mutations, an enrichment of these variants can be observed in regions of low recombination. There are a number of mechanisms by which such a clustering could occur, including genetic perturbations or demographic effects within different populations. Recent genome-wide association studies (GWAS) suggest that single nucleotide polymorphisms (SNPs) associated with complex disease traits are not randomly distributed throughout the genome, but tend to cluster in regions of low recombination. PRINCIPAL FINDINGS: Here we investigated whether deleterious mutations have accumulated in regions of low recombination due to the impact of recent positive selection and genetic hitchhiking. Using publicly available data on common complex diseases and population demography, we observed an enrichment of hitchhiked disease associations in conserved gene clusters subject to selection pressure. Evolutionary analysis revealed that these conserved gene clusters arose by multiple concerted rearrangements events across the vertebrate lineage. We observed distinct clustering of disease-associated SNPs in evolutionary rearranged regions of low recombination and high gene density, which harbor genes involved in immunity, that is, the interleukin cluster on 5q31 or RhoA on 3p21. CONCLUSIONS: Our results suggest that multiple lineage specific rearrangements led to a physical clustering of functionally related and linked genes exhibiting an enrichment of susceptibility loci for complex traits. This implies that besides recent evolutionary adaptations other evolutionary dynamics have played a role in the formation of linked gene clusters associated with complex disease traits
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