Critical research needs for successful food systems adaptation to climate change

There is a growing sense of the fragility of agricultural production in the Global North and South and of increasing risks to food security, as scientific observations confirm significant changes in the Gulf Stream, polar ice, atmospheric CO2, methane release, and other measures of climate change. This sense is heightened as each of us experiences extreme weather, such as the increasing frequency of droughts, floods, unseasonal temperatures, and erratic seasonality. The central research challenge before us is how global, national, regional, and local food systems may adapt to accelerating climate change stresses and uncertainties to ensure the availability, access, consumption, and stability of healthy food for and by all people. Missing aspects of research fall into two broad categories: the impacts of rapid climate change on the environmental systems supporting food production, and climate change’s impact on the predominantly human systems that influence food security. Of particular concern is how different policy and governance mechanisms can support or hinder the collective decision-making needed to promote a swift adaptive response to increase and sustain food security. Human systems research is needed to investigate food system activities beyond production (processing, distribution, consumption, and waste management). It also must consider political, cultural, and regulatory factors that influence behavior and facilitate positive behavioral changes. To accurately envision future scenarios, research is needed to characterize risk comprehensively throughout the food system, assess barriers to and opportunities for changing food systems, and evaluate novel and traditional approaches that may lead to greater food security

The influence of a song on school children’s knowledge growth for sustainable malaria prevention

Music as a potential prevention strategy can play a pivotal role in developing behavioural changes and creating awareness about malaria and malaria prevention. The study was conducted in a moderate-risk malaria district in sub-Saharan Africa. A comparative analysis and pre-and post-intervention evaluation of three teaching intervention methods to teach and educate young children about malaria, e.g., song intervention, drama intervention, and song-and-drama combination, was evaluated. Data were collected by means of pre-and post-intervention interviews with Grade 3 primary school children and teachers, as well as a post-intervention questionnaire with teachers, parents, guardians, and caregivers. The purpose of the study was to investigate knowledge gains on malaria in relation to malaria awareness interventions. The results revealed that the songonly intervention was the most effective learning intervention strategy in this population and that behavioural changes and knowledge growth occurred regarding malaria and malaria prevention in this population. Independent of the teaching styles of each teacher in teaching the song to the children, the findings established that culturally and age-appropriate songs contributed to increasing children’s knowledge growth regarding sustainable malaria prevention.https://www.mdpi.com/journal/sustainabilityam2023Educational PsychologySchool of Health Systems and Public Health (SHSPH

Could a culturally and age-appropriate song contribute towards malaria prevention in primary school learners?

BACKGROUND : Although it is a preventable disease, malaria continues to present one of the major global health challenges. The disease is especially deadly to children under the age of 5 years. This is partly due to the fact that they have yet to build up an immune system to help protect them against malaria. As a prevention strategy, music is one way of communicating knowledge to young children and could therefore potentially be used to change children’s behaviour in order to avoid getting sick from malaria. This exploratory study aimed to compare intervention strategies designed to educate and improve knowledge growth about malaria and its prevention in Grade 3 learners in a high-risk malaria region in Vhembe District, Limpopo Province, South Africa. METHODS : Various intervention strategies were employed and evaluated to determine the most effective intervention method. The study was split into two Phases. Phase 1 used a culturally and age-appropriate song as an intervention, along with a drama piece, a song and drama piece combination, and a control group. The most effective intervention strategy determined during Phase 1 was then subjected to Phase 2, against a control group to validate its efficacy. Questionnaires were used during pre-intervention and post-intervention interviews to evaluate the knowledge growth, if any, of the learners of selected primary schools in two different areas in Vhembe District. Pre-intervention interviews were followed by a specific intervention, based on the respective study groups. After 6 weeks, the post-intervention interviews were done to determine how much learners managed to learn and retain from the intervention received. RESULTS : The study found that the group that had only the song as intervention was the most effective learning intervention method in both Phases 1 and 2. Both phases showed that there was statistical significance in almost all of the nine questions asked on the questionnaires. CONCLUSIONS : The study concluded that a culturally and age-appropriate song can play a significant role in developing behavioural changes and spreading awareness against disease in a high-risk malaria region.The University of Pretoria Institute for Sustainable Malaria Control and MRC Collaborating Centre of Malaria Research provided a small amount of funding for the data collection trips. Financial assistance from Rotary International District 6460 was also provided.https://malariajournal.biomedcentral.comhj2023Educational PsychologySchool of Health Systems and Public Health (SHSPH)UP Centre for Sustainable Malaria Control (UP CSMC

Farmers\u27 Trust in Sources of Production and Climate Information and Their Use of Technology

A regionally representative survey of 900 Inland Pacific Northwest farmers showed that farmers trust other farmers and agribusiness most for production management decisions but trust university Extension most for climate change information. Additionally, in responding to questions about use of the Internet and mobile applications for making farm management decisions, many farmers indicated that they use the Internet daily but mobile applications much less regularly to access farm-related information. These results suggest that university Extension personnel have an important role to play in informing farmers about climate change and can do so effectively by using certain digital tools alongside other more traditional avenues for information delivery

Nano-ADEPT Aeroloads Wind Tunnel Test

A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.

PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Parkinson's disease (PD) is pathologically characterized by the presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra. These intracellular inclusions are largely composed of misfolded α-synuclein (AS), a neuronal protein that is abundant in the vertebrate brain. Point mutations in AS are associated with rare, early-onset forms of PD, although aggregation of the wild-type (WT) protein is observed in the more common sporadic forms of the disease. Here, we employed multidimensional solid-state NMR experiments to assess A53T and E46K mutant fibrils, in comparison to our recent description of WT AS fibrils. We made de novo chemical shift assignments for the mutants, and used these chemical shifts to empirically determine secondary structures. We observe significant perturbations in secondary structure throughout the fibril core for the E46K fibril, while the A53T fibril exhibits more localized perturbations near the mutation site. Overall, these results demonstrate that the secondary structure of A53T has some small differences from the WT and the secondary structure of E46K has significant differences, which may alter the overall structural arrangement of the fibrils

Erythropoietin Stimulates Tumor Growth via EphB4

While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo’s effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin

BioEarth: Envisioning and developing a new regional earth system model to inform natural and agricultural resource management

As managers of agricultural and natural resources are confronted with uncertainties in global change impacts, the complexities associated with the interconnected cycling of nitrogen, carbon, and water present daunting management challenges. Existing models provide detailed information on specific sub-systems (e.g., land, air, water, and economics). An increasing awareness of the unintended consequences of management decisions resulting from interconnectedness of these sub-systems, however, necessitates coupled regional earth system models (EaSMs). Decision makers’ needs and priorities can be integrated into the model design and development processes to enhance decision-making relevance and “usability” of EaSMs. BioEarth is a research initiative currently under development with a focus on the U.S. Pacific Northwest region that explores the coupling of multiple stand-alone EaSMs to generate usable information for resource decision-making. Direct engagement between model developers and non-academic stakeholders involved in resource and environmental management decisions throughout the model development process is a critical component of this effort. BioEarth utilizes a bottom-up approach for its land surface model that preserves fine spatial-scale sensitivities and lateral hydrologic connectivity, which makes it unique among many regional EaSMs. This paper describes the BioEarth initiative and highlights opportunities and challenges associated with coupling multiple stand-alone models to generate usable information for agricultural and natural resource decision-making