The high A_V Quasar Survey: A z=2.027 metal-rich damped Lyman-alpha absorber towards a red quasar at z=3.21

To fully exploit the potential of quasars as probes of cosmic chemical evolution and the internal gas dynamics of galaxies it is important to understand the selection effects behind the quasar samples and in particular if the selection criteria exclude foreground galaxies with certain properties (most importantly a high dust content). Here we present spectroscopic follow-up from the 10.4-m GTC telescope of a dust-reddened quasar, eHAQ0111+0641, from the extended High A_V Quasar (HAQ) survey. We find that the z=3.21 quasar has a foreground Damped Lyman-alpha Absorber (DLA) at z=2.027 along the line of sight. The DLA has very strong metal lines due to a moderately high metallicity (with an inferred lower limit of 25% of the solar metallicity), but a very large gas column density along the line-of-sight in its host galaxy. This discovery is further evidence that there is a dust bias affecting the census of metals, caused by the combined effect of dust obscuration and reddening, in existing samples of z>2 DLAs. The case of eHAQ0111+0641 illustrates that dust bias is not only caused by dust obscuration, but also dust reddening.Comment: 7 pages, 4 figures. Accepted for publication in A&A. A few typos have been correcte

Serendipitous discovery of a projected pair of QSOs separated by 4.5 arcsec on the sky

We present the serendipitous discovery of a projected pair of quasi-stellar objects (QSOs) with an angular separation of $\Delta\theta =4.50$ arcsec. The redshifts of the two QSOs are widely different: one, our programme target, is a QSO with a spectrum consistent with being a narrow line Seyfert 1 AGN at $z=2.05$. For this target we detect Lyman-$\alpha$, \ion{C}{4}, and \ion{C}{3]}. The other QSO, which by chance was included on the spectroscopic slit, is a Type 1 QSO at a redshift of $z=1.68$, for which we detect \ion{C}{4}, \ion{C}{3]} and \ion{Mg}{2}. We compare this system to previously detected projected QSO pairs and find that only about a dozen previously known pairs have smaller angular separation.Comment: 4 pages, 3 figures. Accepted for publication in A

Determining the fraction of reddened quasars in COSMOS with multiple selection techniques from X-ray to radio wavelengths

The sub-population of quasars reddened by intrinsic or intervening clouds of dust are known to be underrepresented in optical quasar surveys. By defining a complete parent sample of the brightest and spatially unresolved quasars in the COSMOS field, we quantify to which extent this sub-population is fundamental to our understanding of the true population of quasars. By using the available multiwavelength data of various surveys in the COSMOS field, we built a parent sample of 33 quasars brighter than $J=20$ mag, identified by reliable X-ray to radio wavelength selection techniques. Spectroscopic follow-up with the NOT/ALFOSC was carried out for four candidate quasars that had not been targeted previously to obtain a 100\% redshift completeness of the sample. The population of high $A_V$ quasars (HAQs), a specific sub-population of quasars selected from optical/near-infrared photometry, is found to contribute $21\%^{+9}_{-5}$ of the parent sample. The full population of bright spatially unresolved quasars represented by our parent sample consists of $39\%^{+9}_{-8}$ reddened quasars defined by having $A_V>0.1$, and $21\%^{+9}_{-5}$ of the sample having $E(B-V)>0.1$ assuming the extinction curve of the Small Magellanic Cloud. We show that the HAQ selection works well for selecting reddened quasars, but some are missed because their optical spectra are too blue to pass the $g-r$ color cut in the HAQ selection. This is either due to a low degree of dust reddening or anomalous spectra. We find that the fraction of quasars with contributing light from the host galaxy is most dominant at $z \lesssim 1$. At higher redshifts the population of spatially unresolved quasars selected by our parent sample is found to be representative of the full population at $J<20$ mag. This work quantifies the bias against reddened quasars in studies that are based solely on optical surveys.Comment: 22 pages, 10 figures, accepted for publication in A&A. The ArXiv abstract has been shortened for it to be printabl

HI gas playing hide-and-seek around a powerful FRI-type quasar at z∼\sim2.1

We present optical spectroscopic and milli-arcsecond scale radio continuum observations of the quasar M1540-1453 ($z_{em}$ = 2.104$\pm$0.002) that shows associated HI 21-cm absorption at $z_{abs}$ = 2.1139. At sub-kpc scales, the powerful radio source with 1.4 GHz luminosity of $5.9\times10^{27}$ WHz$^{-1}$ shows Fanaroff-Riley (FR) class I morphology caused by the interaction with dense gas within 70 pc from the AGN. Interestingly, while there are indications for the presence of absorption from low-ionization species like FeII, SiII and SiIII in the optical spectrum, the expected strong damped Ly$\alpha$ absorption is not detected at the redshift of the HI 21-cm absorber. In comparison to typical high-$z$ quasars, the Ly$\alpha$ emission line is much narrower. The `ghostly' nature of the HI Ly$\alpha$ absorber partially covering the broad line region of extent 0.05 pc and the detection of widespread HI 21-cm absorption covering the diffuse radio source (extent $>$425 pc) imply the presence of a large clumpy HI halo -- which may have been blown by the jet-ISM interaction. Further observations are needed to confirm the `ghostly' nature of the Ly$\alpha$ absorber, and obtain a better understanding of the role played by the jet-ISM interaction in shaping the radio morphology of this powerful AGN. The study showcases how joint radio and optical analysis can shed light on gaseous environment and origin of radio morphology in AGN at high redshifts, when these are still the assembly sites of giant galaxies.Comment: 8 pages, 3 figures, Accepted for Publication in ApJ Letter

Absorption-selected galaxies trace the low-mass, late-type, star-forming population at z∼2−3z\sim2-3

We report on the stellar content, half-light radii and star formation rates of a sample of 10 known high-redshift ($z\gtrsim 2$) galaxies selected on strong neutral hydrogen (HI) absorption (log(N(HI)/cm$^{-2})>19$) toward background quasars. We use observations from the {\it Hubble Space Telescope} (HST) Wide Field Camera 3 in three broad-band filters to study the spectral energy distribution(SED) of the galaxies. Using careful quasar point spread function subtraction, we study their galactic environments, and perform the first systematic morphological characterisation of such absorption-selected galaxies at high redshifts. Our analysis reveals complex, irregular hosts with multiple star-forming clumps. At a spatial sampling of 0.067 arcsec per pixel (corresponding to 0.55 kpc at the median redshift of our sample), 40% of our sample requires multiple S\'ersic components for an accurate modelling of the observed light distributions. Placed on the mass-size relation and the `main sequence' of star-forming galaxies, we find that absorption-selected galaxies at high redshift extend known relations determined from deep luminosity-selected surveys to an order of magnitude lower stellar mass, with objects primarily composed of star-forming, late-type galaxies. We measure half-light radii in the range $r_{1/2} \sim$ 0.4 to 2.6 kpc based on the reddest band (F160W) to trace the oldest stellar populations, and stellar masses in the range $\log (\mathrm{M}_{\star}/\mathrm{M}_{\odot}) \sim$ 8 to 10 derived from fits to the broad-band SED. Spectroscopic and SED-based star formation rates are broadly consistent, and lie in the range log(SFR/M$_{\odot}$yr$^{-1}$) $\sim$0.0 to 1.7.Comment: 17 pages, Accepted for publication in MNRAS. This revision has minor text change

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies.

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta-analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment-emergent adverse event (all p &gt; 0.05). ALA supplementation was safe, even in subsets of studies categorized according to smoking habit, cardiovascular disease, presence of diabetes, pregnancy status, neurological disorders, rheumatic affections, severe renal impairment, and status of children/adolescents at baseline

VLT/X-shooter spectroscopy of the afterglow of the Swift GRB 130606A: Chemical abundances and reionisation at z∼6z\sim6

The reionisation of the Universe is thought to have ended around z~6, as inferred from spectroscopy of distant bright background sources, such as quasars (QSO) and gamma-ray burst (GRB) afterglows. Furthermore, spectroscopy of a GRB afterglow provides insight in its host galaxy, which is often too dim and distant to study otherwise. We present the high S/N VLT/X-shooter spectrum of GRB130606A at z=5.913. We aim to measure the degree of ionisation of the IGM between 5.02<z<5.84 and to study the chemical abundance pattern and dust content of its host galaxy. We measured the flux decrement due to absorption at Ly$\alpha$, $\beta$ and $\gamma$ wavelength regions. The hydrogen and metal absorption lines formed in the host galaxy were fitted with Voigt profiles to obtain column densities. Our measurements of the Ly$\alpha$-forest optical depth are consistent with previous measurements of QSOs, but have a much smaller uncertainty. The analysis of the red damping wing yields a neutral fraction $x_{HI}<0.05$ (3$\sigma$). We obtain column density measurements of several elements. The ionisation corrections due to the GRB is estimated to be negligible (<0.03 dex), but larger corrections may apply due to the pre-existing radiation field (up to 0.4 dex based on sub-DLA studies). Our measurements confirm that the Universe is already predominantly ionised over the redshift range probed in this work, but was slightly more neutral at z>5.6. GRBs are useful probes of the ionisation state of the IGM in the early Universe, but because of internal scatter we need a larger statistical sample to draw robust conclusions. The high [Si/Fe] in the host can be due to dust depletion, alpha-element enhancement, or a combination of both. The very high value of [Al/Fe]=2.40+/-0.78 might connected to the stellar population history. We estimate the host metallicity to be -1.7<[M/H]<-0.9 (2%-13% of solar). (trunc.)Comment: 15 pages, 12 figure

Dust depletion of of metals from local to distant galaxies II: Cosmic dust-to-metal ratio and dust composition

The evolution of the cosmic dust content and the cycle between metals and dust in the interstellar medium (ISM) play a fundamental role in galaxy evolution. The chemical enrichment of the Universe can be traced through the evolution of the dust-to-metals ratio (DTM) and the dust-to-gas ratio (DTG) with metallicity. We use a novel method to determine mass estimates of the DTM, DTG and dust composition based on our previous measurements of the depletion of metals in different environments (the Milky Way, the Magellanic Clouds, and damped Lyman-$\alpha$ absorbers, DLAs, toward quasars and towards gamma-ray bursts, GRBs), which were calculated from the relative abundances of metals in the ISM through absorption-line spectroscopy column densities observed mainly from VLT/UVES and X-shooter, and HST/STIS. We derive the dust extinction from the estimated dust depletion ($A_{V, \rm depl}$) and compare with the $A_{V}$ from extinction. We find that the DTM and DTG ratios increase with metallicity and with the dust tracer [Zn/Fe]. This suggests that grain growth in the ISM is a dominant process of dust production. The increasing trend of the DTM and DTG with metallicity is in good agreement with a dust production and evolution model. Our data suggest that the stellar dust yield is much lower than the metal yield and thus that the overall amount of dust in the warm neutral medium that is produced by stars is much lower. We find that $A_{V,\rm depl}$ is overall lower than $A_{V, \rm ext}$ for the Milky Way and a few Magellanic Clouds lines of sight, a discrepancy that is likely related to the presence of carbonaceous dust. We show that the main elements that contribute to the dust composition are, O, Fe, Si, Mg, C, S, Ni and Al for all the environments. Abundances at low dust regimes suggest the presence of pyroxene and metallic iron in dust.Comment: Accepted for publication in A&A. Abstract abridge

Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2

SummaryTranscriptional-translational feedback loops (TTFLs) are a conserved molecular motif of circadian clocks. The principal clock in mammals is the suprachiasmatic nucleus (SCN) of the hypothalamus. In SCN neurons, auto-regulatory feedback on core clock genes Period (Per) and Cryptochrome (Cry) following nuclear entry of their protein products is the basis of circadian oscillation [1, 2]. In Drosophila clock neurons, the movement of dPer into the nucleus is subject to a circadian gate that generates a delay in the TTFL, and this delay is thought to be critical for oscillation [3, 4]. Analysis of the Drosophila clock has strongly influenced models of the mammalian clock, and such models typically infer complex spatiotemporal, intracellular behaviors of mammalian clock proteins. There are, however, no direct measures of the intracellular behavior of endogenous circadian proteins to support this: dynamic analyses have been limited and often have no circadian dimension [5–7]. We therefore generated a knockin mouse expressing a fluorescent fusion of native PER2 protein (PER2::VENUS) for live imaging. PER2::VENUS recapitulates the circadian functions of wild-type PER2 and, importantly, the behavior of PER2::VENUS runs counter to the Drosophila model: it does not exhibit circadian gating of nuclear entry. Using fluorescent imaging of PER2::VENUS, we acquired the first measures of mobility, molecular concentration, and localization of an endogenous circadian protein in individual mammalian cells, and we showed how the mobility and nuclear translocation of PER2 are regulated by casein kinase. These results provide new qualitative and quantitative insights into the cellular mechanism of the mammalian circadian clock

Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

AimsInsulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial. Confirming the genetic link between insulin resistance, type 2 diabetes, and coronary artery disease, as well as the extent of coronary artery disease, is important and may provide better risk stratification for patients at risk. We investigated whether a genetic risk score of 53 single nucleotide polymorphisms known to be associated with insulin resistance phenotypes was associated with diabetes and burden of coronary artery disease.Methods and resultsWe genotyped patients with a coronary angiography performed in the capital region of Denmark from 2010-2014 and constructed a genetic risk score of the 53 single nucleotide polymorphisms. Logistic regression using quartiles of the genetic risk score was performed to determine associations with diabetes and coronary artery disease. Associations with the extent of coronary artery disease, defined as one-, two- or three-vessel coronary artery disease, was determined by multinomial logistic regression. We identified 4,963 patients, of which 17% had diabetes and 55% had significant coronary artery disease. Of the latter, 27%, 14% and 14% had one, two or three-vessel coronary artery disease, respectively. No significant increased risk of diabetes was identified comparing the highest genetic risk score quartile with the lowest. An increased risk of coronary artery disease was found for patients with the highest genetic risk score quartile in both unadjusted and adjusted analyses, OR 1.21 (95% CI: 1.03, 1.42, p = 0.02) and 1.25 (95% CI 1.06, 1.48, pConclusionsAmong patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden