The Role Of Periodontal Disease In Lymphatic Function

Research poster addressing the question: Does periodontal disease affect lymphatic function? Gingival lymphatic vessels drain interstitial fluid and transport immune cells to lymph nodes but despite this, it is unknown how the lymphatic system impacts periodontal disease in humans. In light of this, studies have been observed on animals with the vascular endothelial growth factor C (VEGFC), a growth factor known to be increased in periodontal patients. VEGFC is involved in lymphatic hyperplasia and lymphangiogenesis, the proliferation of lymphatic endothelial cells. This growth factor is believed to affect gingival lymphatic function in periodontitis patients. When reviewing the literature, it is evident that the VEGFC receptor is of main interest when investigating lymphatics and periodontitis. One study found that inducing the overexpression of VEGFC in mice infected with P. gingivalis resulted in lymphatic hyperplasia and reduced lymphatic flow, meaning the invasive bacteria is not being cleared out as it should. Another study found that mice lacking gingival lymphatics experienced greater bone loss in periodontitis than mice with functional lymphatic systems.https://dune.une.edu/dh_studpost/1007/thumbnail.jp

Life Without Parole Sentencing in North Carolina

What explains the puzzle of life without parole (LWOP) sentencing in the United States? In the past two decades, LWOP sentences have reached record highs, with over 50,000 prisoners serving LWOP. Yet during this same period, homicide rates have steadily declined. The U.S. Supreme Court has limited the use of juvenile LWOP in Eighth Amendment rulings. Further, death sentences have steeply declined, reaching record lows. Although research has examined drivers of incarceration patterns for certain sentences, there has been little research on LWOP imposition. To shed light on what might explain the sudden rise of LWOP, we examine characteristics of the more than 1,627 cases in which LWOP was imposed from 1995 to 2017, in North Carolina, one of the states that imposes the largest numbers of these sentences. We begin by analyzing defendant race, crime, and sentence patterns by county. We associate LWOP with homicide rates, and examine interactions between homicide, victim race, and prior LWOP sentencing. This first empirical analysis of adult LWOP sentences finds important local variations in its imposition. We find that as the homicide rate increases within a county, we observe fewer LWOP sentences. We find that fewer LWOP sentences are predicted to occur as the number of black victim homicides increase in a county, but no such relationship is found when considering the number of white victim homicides. Finally, we find a strong path dependency and concentration of LWOP sentences in counties, where counties that have imposed LWOP sentences in the past are more likely to continue to do so. These findings have implications for efforts to reconsider the most severe sentences in the U.S., and they suggest that prosecutorial discretion in seeking long sentences will be important subjects for future research and policy

Carlson\u27s Trophic State Index and Southern Minnesota Lakes

Carlson\u27s Trophic State Index (TSI) uses phosphorous and chlorophyll-a concentrations as well as Secchi disk readings to measure the quality of Mankato-area lakes. The purpose of our research is to determine if heterogeneity exists between three distinct sites within each lake. EPA approved techniques were used to obtain Secchi disk readings and to measure the concentration of chlorophyll-a and phosphorus. Preliminary results indicate that heterogeneity exists, between phosphorus concentrations at different points on each lake. Spatial variability was also found in chlorophyll-a concentrations. Heterogeneity was not found in the Secchi disk data. Further data analysis will determine if heterogeneity exists in the TSI data for each lake. Initially, these results suggest that lakes are not well mixed. Multiple sampling sites, therefore, should be analyzed to accurately measure the trophic state of a lake

Relationship Between Gait Mechanics and the Speed of the Trot in the Weimaraner Dog Breed

While the size of the Weimaraner may assist in the breed performing the tasks of a sporting dog, the large size coupled with these tasks may also make the breed more susceptible to orthopedic issues. The understanding of the normal gait mechanics of the Weimaraner can be a useful tool in examining for gait abnormalities associated with these orthopedic issues, and yet, research concerning breed-specific gaits in the canine is limited. Therefore, study objectives were to define the normal Weimaraner trotting kinematics and determine the influence of speed on these parameters. Markers were attached to palpation points on the limbs and head of American Kennel Club registered Weimaraners. Dogs were tracked while performing a slow (1.2-1.7 m/s) and fast (1.9-2.3 m/s) trotting speed. Frame-by-frame analysis was performed. Paw ground contact and lift-off was documented and marker displacement was tracked. At both speeds, the trot had a diagonal footfall sequence with diagonal limb pairing alternating between diagonal bipedal support and suspension. The faster speed was achieved with significant increases in stride length and displacements of the head, withers, and fore and hind paws (P \u3c.05). Range of motion of the elbow and hip significantly increased as the dog transitioned from a slow to fast speed (P \u3c.05). Through gait analysis, the Weimaraner trot was defined as a 2-beat diagonal rhythm gait with suspension. Speed did not change these characteristics, but did influence stride length and linear and angular displacements, and thus, should be a consideration in clinical examination

Implication of lateral genetic transfer in the emergence of Aeromonas hydrophila isolates of epidemic outbreaks in channel catfish.

To investigate the molecular basis of the emergence of Aeromonas hydrophila responsible for an epidemic outbreak of motile aeromonad septicemia of catfish in the Southeastern United States, we sequenced 11 A. hydrophila isolates that includes five reference and six recent epidemic isolates. Comparative genomics revealed that recent epidemic A. hydrophila isolates are highly clonal, whereas reference isolates are greatly diverse. We identified 55 epidemic-associated genetic regions with 313 predicted genes that are present in epidemic isolates but absent from reference isolates and 35% of these regions are located within genomic islands, suggesting their acquisition through lateral gene transfer. The epidemic-associated regions encode predicted prophage elements, pathogenicity islands, metabolic islands, fitness islands and genes of unknown functions, and 34 of the genes encoded in these regions were predicted as virulence factors. We found two pilus biogenesis gene clusters encoded within predicted pathogenicity islands. A functional metabolic island that encodes a complete pathway for myo-inositol catabolism was evident by the ability of epidemic A. hydrophila isolates to use myo-inositol as a sole carbon source. Testing of A. hydrophila field isolates found a consistent correlation between myo-inositol utilization as a sole carbon source and the presence of an epidemic-specific genetic marker. All epidemic isolates and one reference isolate shared a novel O-antigen cluster. Altogether we identified four different O-antigen biosynthesis gene clusters within the 11 sequenced A. hydrophila genomes. Our study reveals new insights into the evolutionary changes that have resulted in the emergence of recent epidemic A. hydrophila strains

Surface and subsurface composition of the life in the Atacama field sites from rover data and orbital image analysis

The Life in the Atacama project examined six different sites in the Atacama Desert (Chile) over 3 years in an attempt to remotely detect the presence of life with a rover. The remote science team, using only orbital and rover data sets, identified areas with a high potential for life as targets for further inspection by the rover. Orbital data in the visible/near infrared (VNIR) and in the thermal infrared (TIR) were used to examine the mineralogy, geomorphology, and chlorophyll potential of the field sites. Field instruments included two spectrometers (VNIR reflectance and TIR emission) and a neutron detector: this project represents the first time a neutron detector has been used as part of a “science-blind” rover field test. Rover-based spectroscopy was used to identify the composition of small scale features not visible in the orbital images and to improve interpretations of those data sets. The orbital and ground-based data sets produced consistent results, suggesting that much of the field sites consist of altered volcanic terrains with later deposits of sulfates, quartz, and iron oxides. At one location (Site A), the ground-based spectral data revealed considerably greater compositional diversity than was seen from the orbital view. One neutron detector transect provided insight into subsurface hydrogen concentrations, which correlated with life and surface features. The results presented here have implications for targeting strategies, especially for future Mars rover missions looking for potential habitats/paleohabitats