Do Instructions Intended to Reduce False Positives Improve the Measurement of Physical Partner Violence Victimization Among Adolescents and Young Adults?

Objective: We examine how instructions to exclude behaviors occurring in playful or joking contexts influence the measurement of physical partner violence victimization. Specifically, we demonstrate how such instructions influence the prevalence and validity of self-reported victimization. Method: Study 1 used a Think Aloud procedure to evaluate thoughts of college students (n = 451) reporting victimization experiences that occurred during high school. Participants were randomized to report on physical partner violence victimization with or without instructions to exclude playful acts. Study 2 experimentally evaluated whether the instructions affect the criterion validity of victimization scores with measures of depressive symptoms and emotion regulation among first-year college students (n = 615). Study 3 sought to replicate findings from Study 2 in a community sample of 18–25-year-olds (n = 398), using alternative violence items, response formats, and a different recall period. Study 4 utilized a short-term longitudinal design to replicate the pattern of findings from Studies 2 and 3, and examine how instructions influence self-reports of revictimization over a 2-month follow-up among first-year college students (n = 887). Study 5 presents a single-paper meta-analysis that synthesizes prevalence rates across these four studies. Results: Overall, instructions designed to eliminate aggressive acts in joking contexts did not consistently influence prevalence rates of victimization or improve criterion validity over standard instructions. Conclusions: Instructions designed to exclude behaviors occurring in playful or joking contexts do not necessarily produce more valid self-reports of physical partner violence victimization, as compared with standard instructions

Gender and racial/ethnic disparities in rates of publishing and inclusion in scientific-review processes

Sexism and racism in academia have contributed to women and people of color being underrepresented at increasing levels of the academic hierarchy. We investigated whether people with socially marginalized identities experience disparities regarding rates of publishing and inclusion in the scientific-review process. Using a sample of academics in psychology departments at research-focused universities in the United States (n = 885), we found gender disparities for PhD holders and racial/ethnic disparities for graduate students. Specifically, female PhD holders and graduate students of color reported fewer publications and were less likely to be included in the scientific-review process compared with male PhD holders and White graduate students, respectively. Differences in research activity by gender and race/ethnicity in a contemporary sample of psychologists reflected a 'leaky pipeline' that persists in psychology department

Assessing the within-person variability of internal and external sexual consent

Sexual consent is often conceptualized as an internal willingness to engage in sexual activity, which can be communicated externally to a sexual partner. Internal sexual consent comprises feelings of physical response, safety/comfort, arousal, agreement/want, and readiness; external sexual consent includes communication cues that may be explicit or implicit and verbal or nonverbal. Most previous research on sexual consent has focused on between-person differences; little attention has been devoted to examining the within-person variation of sexual consent across time. We conducted a 28-day experience sampling methodology (ESM) study with a sample of adults (N = 113) to assess fluctuations in internal and external sexual consent across a given person’s sexual events. We found that more than 50% and up to 80% of the variance in sexual consent scores could be accounted for by within-person variability. The type of sexual behavior participants engaged in during a sexual event predicted their internal and external consent. Further, internal consent feelings predicted external consent communication. Overall, our findings provided initial evidence regarding the extent that situational contexts are relevant for sexual consent. ESM study designs may be used to further investigate the potential contextual, intrapersonal, and interpersonal factors associated with internal and external sexual consent

Developing valid and feasible measures of sexual consent for experience sampling methodology

Preliminary evidence indicates that people’s sexual consent (i.e., their willingness to engage in sexual activity and communication of that willingness) varies across time and context. Study designs that assess sexual consent at multiple time points (e.g., experience sampling methodology [ESM]) are needed to better understand the within-person variability of sexual consent. However, extant validated measures of sexual consent are not appropriate for ESM studies, which require shorter assessments due to the increased burden this methodology has on participants. As such, the goal of the present study was to develop ESM measures of sexual consent based on items that have previously been validated for use in cross-sectional surveys. We selected items that balanced face validity as evidenced by cognitive interviews (n = 10) and content validity as evidenced by experts’ ratings (n = 6). To assess the construct validity and feasibility of these items, we administered the selected ESM measures of sexual consent in a seven-day pilot study (n = 12). The results suggested that the ESM measures developed in the present study were a valid and feasible assessment of people’s experience-specific internal consent feelings and external consent communication. We conclude with recommendations for sex researchers interested in ESM

Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort.

IntroductionSleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption. Poor sleep among psoriasis patients is particularly concerning because psoriasis is independently associated with many of the same comorbidities as sleep dysfunction, including cardiovascular disease, obesity, and depression. Given the high prevalence and serious consequences of disordered sleep in psoriasis, it is vital to understand the nature of sleep disturbance in this population. This study was designed to help meet this need by using survey data from Citizen Pscientist, an online patient portal developed by the National Psoriasis Foundation.MethodsOur analysis included 3118 participants who identified as having a diagnosis by a physician of psoriasis alone or psoriasis with psoriatic arthritis. Demographic information, psoriasis severity and duration, sleep apnea status, smoking and alcohol consumption, itch timing, and sleep characteristics were included. Two separate multivariate logistic regression models in STATA were used to determine whether the presence of psoriatic arthritis, age, gender, body mass index, comorbid sleep apnea, psoriasis severity, timing of worst itch, smoking status, or high-risk alcohol consumption were associated with sleep difficulty or low sleep quantity, defined by the American Academy of Sleep Medicine as less than 7 h of sleep per night on average.ResultsResults from the multivariate logistic regressions found that sleep difficulty was associated with psoriatic arthritis (OR 2.15, 95% CI [1.79-2.58]), female gender (2.03 [1.67-2.46]), obese body mass index (BMI ≥ 30) (1.25 [1.00-1.56]), sleep apnea (1.41 [1.07-1.86]), psoriasis severity of moderate (1.59 [1.30-1.94]) or severe (2.40 [1.87-3.08]), and smoking (1.60 [1.26-2.02]). Low sleep quantity was associated with obese BMI (1.62 [1.29-2.03]), sleep apnea (1.30 [1.01-1.68]), psoriasis severity of moderate (1.41 [1.16-1.72]) or severe (1.40 [1.11-1.76]), and smoking (1.62 [1.31-2.00]). Sleep difficulty and low sleep quantity were not associated with age, alcohol consumption, or timing of worst itch.ConclusionThese results are potentially meaningful in several aspects. We identify an important distinction between sleep difficulty and sleep quantity in psoriatic disease, whereby having psoriatic arthritis and being female are each associated with sleep difficulty despite no association with low sleep quantity. Furthermore, there is conflicting evidence from prior studies as to whether psoriasis severity is associated with sleep difficulty, but this well-powered, large study revealed a strong, graded relationship between psoriasis severity and both sleep difficulty and low sleep quantity. Overall, our results show that both sleep difficulty and low sleep quantity were associated with multiple factors in this analysis of a large psoriatic cohort. These findings suggest that dermatologists may gather clinically useful information by screening psoriatic patients for trouble sleeping and low sleep quantity to identify potential comorbidities and to more effectively guide disease management

High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.

BACKGROUND/OBJECTIVE: As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity. METHODS: Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice. RESULTS: While mice given sugar-sweetened water do not gain significant weight, they do show subtle differences in body composition and caloric intake. When given sugar-sweetened water, mice show similar alterations to AgRP neuronal excitability as in high-fat diet obese models. Increased sugar consumption also primes mice for increased caloric intake and weight gain when given access to a HFD. CONCLUSIONS: Our results show that elevated sucrose consumption increased activity of AgRP neurons and altered synaptic excitability. This may contribute to obesity in mice and humans with access to more palatable (HFD) diets

Star-Forming Galaxies at z~2 and the Formation of the Metal-Rich Globular Cluster Population

We examine whether the super star-forming clumps (R~1-3 kpc; M~10^8-10^9.5 Msun) now known to be a key component of star-forming galaxies at z~2 could be the formation sites of the locally observed old globular cluster population. We find that the stellar populations of these super star-forming clumps are excellent matches to those of local metal-rich globular clusters. Moreover, this globular cluster population is known to be associated with the bulges / thick disks of galaxies, and we show that its spatial distribution and kinematics are consistent with the current understanding of the assembly of bulges and thick disks from super star-forming clumps at high redshift. Finally, with the assumption that star formation in these clumps proceeds as a scaled-up version of local star formation in molecular clouds, this formation scenario reproduces the observed numbers and mass spectra of metal-rich globular clusters. The resulting link between the turbulent and clumpy disks observed in high-redshift galaxies and a local globular cluster population provides a plausible co-evolutionary scenario for several of the major components of a galaxy: the bulge, the thick disk, and one of the globular cluster populations.Comment: Accepted for publication in MNRAS Letters. 5 pages, 2 figure

An ISO--SWS survey of molecular hydrogen in Starburst and Seyfert Galaxies

We present results from a survey of molecular hydrogen emission from a sample of Starburst and Seyfert galaxies carried out with the Infrared Space Observatory (ISO). Pure rotational H_2 emission has been detected in a number of extragalactic objects and a variety of environments. A number of transitions from S(7) to S(0) are detected in both Starbursts and Seyferts. Using excitation diagrams we derive temperatures and masses of the ``warm'' molecular hydrogen. We find that the temperature of the ``warm'' gas is similar in Starbursts and Seyferts (those Seyferts for which we have firm detections of the S(0) line) with a value of around T~150 K. This ``warm'' gas accounts for as much as 10% of the total galactic mass (as probed by CO molecular observations) in Starbursts. The fraction of ``warm'' gas is overall higher in Seyferts, ranging between 2--35%. We then investigate the origin of the warm H_2 emission. Comparison with published theoretical models and Galactic templates implies that although emission from photodissociation regions (PDR) alone could explain the emission from Starbursts and Seyferts, most likely a combination of PDR, shock emission and gas heated by X-rays (mostly for the Seyferts) is responsible for H_2 excitation in extragalactic environments. Finally, we find that although PAH and H_2 line emission correlate well in Starbursts and the large scale emission in AGN, H_2 emission is much stronger compared to PAH emission in cases where a ``pure'' AGN dominates the energy output.Comment: Astronomy and Astrophysics in pres

Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial

BACKGROUND: Soluble fibers lower serum lipids, but are difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of a concentrated oat β-glucan on cardiovascular disease (CVD) endpoints in human subjects. We also compared the fermentability of concentrated oat β-glucan with inulin and guar gum in a model intestinal fermentation system. METHODS: Seventy-five hypercholesterolemic men and women were randomly assigned to one of two treatments: 6 grams/day concentrated oat β-glucan or 6 grams/day dextrose (control). Fasting blood samples were collected at baseline, week 3, and week 6 and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, homocysteine and C-reactive protein (CRP). To estimate colonic fermentability, 0.5 g concentrated oat β-glucan was incubated in a batch model intestinal fermentation system, using human fecal inoculum to provide representative microflora. Fecal donors were not involved with the β-glucan feeding trial. Inulin and guar gum were also incubated in separate serum bottles for comparison. RESULTS: Oat β-glucan produced significant reduction from baseline in total cholesterol (-0.3 ± 0.1 mmol/L) and LDL cholesterol (-0.3 ± 0.1 mmol/L), and the reduction in LDL cholesterol were significantly greater than in the control group (p = 0.03). Concentrated oat β-glucan was a fermentable fiber and produced total SCFA and acetate concentrations similar to inulin and guar gum. Concentrated oat β-glucan produced the highest concentrations of butyrate at 4, 8, and 12 hours. CONCLUSION: Six grams concentrated oat β-glucan per day for six weeks significantly reduced total and LDL cholesterol in subjects with elevated cholesterol, and the LDL cholesterol reduction was greater than the change in the control group. Based on a model intestinal fermentation, this oat β-glucan was fermentable, producing higher amounts of butyrate than other fibers. Thus, a practical dose of β-glucan can significantly lower serum lipids in a high-risk population and may improve colon health

Diazoxide choline extended‐release tablet in people with Prader‐Willi syndrome: results from long‐term open‐label study

Objective: This study assessed the effect of 1-year administration of diazoxide choline extended-release tablet (DCCR) on hyperphagia and other complications of Prader-Willi syndrome (PWS). Methods: The authors studied 125 participants with PWS, age ≥ 4 years, who were enrolled in the DESTINY PWS Phase 3 study and who received DCCR for up to 52 weeks in DESTINY PWS and/or its open-label extension. The primary efficacy endpoint was Hyperphagia Questionnaire for Clinical Trials (HQ-CT) score. Other endpoints included behavioral assessments, body composition, hormonal measures, and safety. Results: DCCR administration resulted in significant improvements in HQ-CT (mean [SE] −9.9 [0.77], p < 0.0001) and greater improvements in those with more severe baseline hyperphagia (HQ-CT > 22). Improvements were seen in aggression, anxiety, and compulsivity (all p < 0.0001). There were reductions in leptin, insulin, and insulin resistance, as well as a significant increase in adiponectin (all p < 0.004). Lean body mass was increased (p < 0.0001). Disease severity was reduced as assessed by clinician and caregiver (both p < 0.0001). Common treatment-emergent adverse events included hypertrichosis, peripheral edema, and hyperglycemia. Adverse events infrequently resulted in discontinuation (7.2%). Conclusions: DCCR administration to people with PWS was well tolerated and associated with broad-ranging improvements in the syndrome. Sustained administration of DCCR has the potential to reduce disease severity and the burden of care for families