PARTICIPATING IN THE KNOWLEDGE OF GOD: AN ENGAGEMENT WITH THE TRINITARIAN EPISTEMOLOGY OF T. F. TORRANCE

The overall aim of this thesis is to assess the viability of a particular understanding of participation in the knowledge of God for the postmodern, scientific context in which it is now located. Through a critical engagement of the Trinitarian epistemology of T. F. Torrance, this thesis provides a more holistic, complex vision of participation in the knowledge of God that moves beyond the problems of reductionist accounts. Part I of the thesis identifies and defines the modern problem of reductionist accounts of theological epistemology. To overcome these problems, this thesis proposes a complex vision of the knowledge of God through an engagement and expansion of Torrance’s Trinitarian epistemology. Part II delineates and analyzes seven general dynamics which comprise the nature of the knowledge of God for Torrance. Before moving to the center of his theological epistemology, this section provides an introduction and assessment of the general dynamics at work throughout his discussions of the knowledge of God. Part III goes to the heart of Torrance’s epistemology, the Triune God. This section begins by examining how the persons and relations of the ontological Trinity exercise a governing influence upon Torrance’s theological epistemology. From this Trinitarian framework, this section then turns to expand and appraise three epistemological dynamics which consequently become centrally important: knowledge of God as personal, relational, and participatory. This section contends that these forms of knowledge involve the whole person and a way of life. This vision of participation extends the Trinitarian epistemology of Torrance with priorities to which his theological writings clearly point but which he himself did not develop. Part IV concludes the thesis by drawing together the assessments made along the way concerning knowledge of God in a postmodern, scientific age and proposing an epistemological model that moves beyond the problems of reductionism

AN ANALYSIS OF SAFETY CULTURE & SAFETY TRAINING: COMPARING THE IMPACT OF UNION, NON-UNION, AND RIGHT TO WORK CONSTRUCTION VENUES

The construction industry is one of the most dangerous sectors of the US economy. As such, the safety attitudes and climate within small (residential) contracting firms may play a role in providing a safe culture and working environment. The intent of this practitioner-based research study is to compare and determine if there is a difference in safety practices—based on documented field inspections and their related original number of violations observed by OSHA—between union residential carpentry contractors in the St. Louis area and: 1) non-union residential carpentry contractors in the St. Louis area; 2) non-union residential carpentry contractors across Missouri; and 3) non-union carpentry contractors in the four contiguous Right to Work (Nebraska, Kansas, Oklahoma, and Arkansas) states to Missouri, solely under federal OSHA compliance. Three separate T-tests (for independent samples) were utilized to measure the outcomes of the various groups observe

Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016.

This study examines the roles of age, period, and cohort in influenza mortality trends over the years 1959-2016 in the United States. First, we use Lexis surfaces based on Serfling models to highlight influenza mortality patterns as well as to identify lingering effects of early-life exposure to specific influenza virus subtypes (e.g., H1N1, H3N2). Second, we use age-period-cohort (APC) methods to explore APC linear trends and identify changes in the slope of these trends (contrasts). Our analyses reveal a series of breakpoints where the magnitude and direction of birth cohort trends significantly change, mostly corresponding to years in which important antigenic drifts or shifts took place (i.e., 1947, 1957, 1968, and 1978). Whereas child, youth, and adult influenza mortality appear to be influenced by a combination of cohort- and period-specific factors, reflecting the interaction between the antigenic experience of the population and the evolution of the influenza virus itself, mortality patterns of the elderly appear to be molded by broader cohort factors. The latter would reflect the processes of physiological capital improvement in successive birth cohorts through secular changes in early-life conditions. Antigenic imprinting, cohort morbidity phenotype, and other mechanisms that can generate the observed cohort effects, including the baby boom, are discussed

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic.

Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 "swine flu" pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 "Spanish flu." Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 "swine flu" pandemic and during the resurgent 2013-2014 H1N1 outbreak for those born at the time of the 1957 H2N2 "Asian flu" pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.IMPORTANCE The relatively low mortality experienced by older individuals during the 2009 H1N1 influenza virus pandemic has been well documented. However, reported situations in which previous influenza virus exposures have enhanced susceptibility are rare and poorly understood. One such instance occurred in 1918-when those born during the heterosubtypic 1890 H3Nx influenza virus pandemic experienced the highest levels of excess mortality. Here, we demonstrate that this phenomenon was not unique to the 1918 H1N1 pandemic but that it also occurred during the contemporary 2009 H1N1 pandemic and 2013-2014 H1N1-dominated season for those born during the heterosubtypic 1957 H2N2 "Asian flu" pandemic. These data highlight the heretofore underappreciated phenomenon that, in certain instances, prior exposure to pandemic influenza virus strains can enhance susceptibility during subsequent pandemics. These results have important implications for pandemic risk assessment and should inform laboratory studies aimed at uncovering the mechanism responsible for this effect

Resistivity-driven State Changes in Vertically Stratified Accretion Disks

We investigate the effect of shear viscosity and Ohmic resistivity on the magnetorotational instability (MRI) in vertically stratified accretion disks through a series of local simulations with the Athena code. First, we use a series of unstratified simulations to calibrate physical dissipation as a function of resolution and background field strength; the effect of the magnetic Prandtl number, Pm = viscosity/resistivity, on the turbulence is captured by ~32 grid zones per disk scale height, H. In agreement with previous results, our stratified disk calculations are characterized by a subthermal, predominately toroidal magnetic field that produces MRI-driven turbulence for |z| < 2 H. Above |z| = 2 H, magnetic pressure dominates and the field is buoyantly unstable. Large scale radial and toroidal fields are also generated near the mid-plane and subsequently rise through the disk. The polarity of this mean field switches on a roughly 10 orbit period in a process that is well-modeled by an alpha-omega dynamo. Turbulent stress increases with Pm but with a shallower dependence compared to unstratified simulations. For sufficiently large resistivity, on the order of cs H/1000, where cs is the sound speed, MRI turbulence within 2 H of the mid-plane undergoes periods of resistive decay followed by regrowth. This regrowth is caused by amplification of toroidal field via the dynamo. This process results in large amplitude variability in the stress on 10 to 100 orbital timescales, which may have relevance for partially ionized disks that are observed to have high and low accretion states.Comment: very minor changes, accepted to Ap

Where is the Radiation Edge in Magnetized Black Hole Accretion discs?

General Relativistic (GR) Magnetohydrodynamic (MHD) simulations of black hole accretion find significant magnetic stresses near and inside the innermost stable circular orbit (ISCO), suggesting that such flows could radiate in a manner noticeably different from the prediction of the standard model, which assumes that there are no stresses in that region. We provide estimates of how phenomenologically interesting parameters like the ``radiation edge", the innermost ring of the disc from which substantial thermal radiation escapes to infinity, may be altered by stresses near the ISCO. These estimates are based on data from a large number of three-dimensional GRMHD simulations combined with GR ray-tracing. For slowly spinning black holes ($a/M<0.9$), the radiation edge lies well inside where the standard model predicts, particularly when the system is viewed at high inclination. For more rapidly spinning black holes, the contrast is smaller. At fixed total luminosity, the characteristic temperature of the accretion flow increases between a factor of $1.2-2.4$ over that predicted by the standard model, whilst at fixed mass accretion rate, there is a corresponding enhancement of the accretion luminosity which may be anywhere from tens of percent to order unity. When all these considerations are combined, we find that, for fixed black hole mass, luminosity, and inclination angle, our uncertainty in the characteristic temperature of the radiation reaching distant observers due to uncertainty in dissipation profile (around a factor of 3) is {\it greater} than the uncertainty due to a complete lack of knowledge of the black hole's spin (around a factor of 2) and furthermore that spin estimates based on the stress-free inner boundary condition provide an upper limit to $a/M$.Comment: 20 pages, 17 figures, accepted by MNRAS; major changes to original, including entirely new sections discussing characteristic temperature of black hole accretion flows and implications for measurements of black hole spin, along with substantially expanded conclusio

Phase II Trial of Dasatinib for Patients with Acquired Resistance to Treatment with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Erlotinib or Gefitinib

Introduction:Dual inhibition of SRC- and EGFR-dependent pathways may overcome acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients with lung adenocarcinoma with EGFR mutations. The SRC inhibitor dasatinib demonstrates antitumor activity in gefitinib-resistant cells lines and xenografts. Dasatinib is tolerable for patients with advanced non-small cell lung cancer, and in combination with erlotinib.Methods:We conducted this phase II study of dasatinib 70 mg twice daily in patients with EGFR-mutant lung adenocarcinoma and acquired resistance to EGFR-TKIs. After a protocol amendment based on evolving data about both drugs, patients received dasatinib at a dose of 100 mg daily with continued erlotinib after developing acquired resistance. Enrolled patients either harbored an activating mutation in EGFR or experienced clinical benefit with single-agent erlotinib or gefitinib, followed by RECIST documented progression while being treated with an EGFR-TKI.Results:Twenty-one patients were enrolled, 9 under the original trial design and 12 after the protocol amendments. We observed no complete or partial responses (0% observed rate, 95% confidence interval: 0–18%). The median time to progression was 0.5 months (range, 0.2–1.8 months) in patients treated with dasatinib and 0.9 months (range, 0.4–5 months) for patients treated with dasatinib and erlotinib in combination. Pleural effusions and dyspnea were frequent toxicities.Conclusions:Dasatinib has no activity in patients with EGFR-mutant lung adenocarcinoma with acquired resistance to erlotinib and gefitinib

Pedicle ties provide a rapid and safe method for feline ovariohysterectomy

OBJECTIVES: The specific objectives of the present study were to 1) evaluate the rate of hemorrhage-related complications across a large number of feline pedicle tie procedures and 2) evaluate for a difference in surgical time between traditional pedicle double-ligation and pedicle tie procedures. METHODS: In the initial phase of the study 2136 intact female cats underwent an ovariohysterectomy using the pedicle tie technique. Hemorrhagic complications not detected intra-operatively were to be confirmed via exploratory surgery or necropsy. The second phase of the study recorded the duration of surgery for 4 groups: kittens undergoing pedicle ties (n=50), kittens undergoing pedicle double ligation (n=49), adult cats undergoing pedicle ties (n=50), and adult cats undergoing pedicle double ligation (n=54). Kittens were defined as a cat 4 months old or younger. Statistical comparisons of age, body weight, and surgical times between the pedicle tie and pedicle double ligation groups were performed within, but not between, kitten and adult cat categories. RESULTS: Six of 2136 cats (0.281%) experienced a hemorrhage-related complication associated with the ovarian pedicle. Five of the 6 ovarian pedicle hemorrhage-related complications were recognized and corrected intra-operatively, with the remaining hemorrhagic event being detected post-operatively. Surgical times were significantly shorter in pedicle tie kittens compared to pedicle double ligature kittens (4.7 ± 0.1 minutes and 6.7 ± 0.1 minutes, respectively) and pedicle tie adult cats compared to pedicle double ligature adult cats (5.0 ± 0.2 minutes and 7.0 ± 0.2 minutes, respectively). CONCLUSIONS AND RELEVANCE: The present study demonstrates that the pedicle tie technique is associated with a very low risk for hemorrhage-related complications and is significantly faster than double ligating the ovarian pedicle in both kittens and adult cats. Use of the pedicle tie technique has the potential to be of significant economic benefit in institutions that are performing large numbers of feline ovariohysterectomies

Multivariate time-series analysis of biomarkers from a dengue cohort offers new approaches for diagnosis and prognosis

Dengue is a major public health problem worldwide with distinct clinical manifestations: an acute presentation (dengue fever, DF) similar to other febrile illnesses (OFI) and a more severe, life-threatening form (severe dengue, SD). Due to nonspecific clinical presentation during the early phase of dengue infection, differentiating DF from OFI has remained a chal-lenge, and current methods to determine severity of dengue remain poor early predictors. We present a prospective clinical cohort study conducted in Caracas, Venezuela from 2001–2005, designed to determine whether clinical and hematological parameters could distinguish DF from OFI, and identify early prognostic biomarkers of SD. From 204 enrolled suspected dengue patients, there were 111 confirmed dengue cases. Piecewise mixed effects regression and nonparametric statistics were used to analyze longitudinal records. Decreased serum albumin and fibrinogen along with increased D-dimer, thrombin-anti-thrombin complex, activated partial thromboplastin time and thrombin time were prognostic of SD on the day of defervescence. In the febrile phase, the day-to-day rates of change in serum albumin and fibrinogen concentration, along with platelet counts, were significantly decreased in dengue patients compared to OFI, while the day-to-day rates of change of lym-phocytes (%) and thrombin time were increased. In dengue patients, the absolute lympho-cytes to neutrophils ratio showed specific temporal increase, enabling classification of dengue patients entering the critical phase with an area under the ROC curve of 0.79. Secondary dengue patients had elongation of Thrombin time compared to primary cases while the D-dimer formation (fibrinolysis marker) remained always lower for secondary compared to primary cases. Based on partial analysis of 31 viral complete genomes, a high frequency of C-to-T transitions located at the third codon position was observed, suggesting deamina-tion events with five major hot spots of amino acid polymorphic sites outside in non-structural proteins. No association of severe outcome was statistically significant for any of the five major polymorphic sites found. This study offers an improved understanding of dengue hemostasis and a novel way of approaching dengue diagnosis and disease prognosis using piecewise mixed effect regression modeling. It also suggests that a better discrimination of the day of disease can improve the diagnostic and prognostic classification power of clinical variables using ROC curve analysis. The piecewise mixed effect regression model corroborated key early clinical determinants of disease, and offers a time-series approach for future vaccine and pathogenesis clinical studies