Prospective relationships between body weight and physical activity: an observational analysis from the NAVIGATOR study

Objectives: While bidirectional relationships exist between body weight and physical activity, direction of causality remains uncertain and previous studies have been limited by self-reported activity or weight and small sample size. We investigated the prospective relationships between weight and physical activity. Design: Observational analysis of data from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) study, a double-blinded randomised clinical trial of nateglinide and valsartan, respectively. Setting Multinational study of 9306 participants. Participants: Participants with biochemically confirmed impaired glucose tolerance had annual measurements of both weight and step count using research grade pedometers, worn for 7 days consecutively. Along with randomisation to valsartan or placebo plus nateglinide or placebo, participants took part in a lifestyle modification programme. Outcome measures: Longitudinal regression using weight as response value and physical activity as predictor value was conducted, adjusted for baseline covariates. Analysis was then repeated with physical activity as response value and weight as predictor value. Only participants with a response value preceded by at least three annual response values were included. Results: Adequate data were available for 2811 (30%) of NAVIGATOR participants. Previous weight (χ2=16.8; p<0.0001), but not change in weight (χ2=0.1; p=0.71) was inversely associated with subsequent step count, indicating lower subsequent levels of physical activity in heavier individuals. Change in step count (χ2=5.9; p=0.02) but not previous step count (χ2=0.9; p=0.34) was inversely associated with subsequent weight. However, in the context of trajectories already established for weight (χ2 for previous weight measurements 747.3; p<0.0001) and physical activity (χ2 for previous step count 432.6; p<0.0001), these effects were of limited clinical importance. Conclusions: While a prospective bidirectional relationship was observed between weight and physical activity, the magnitude of any effect was very small in the context of natural trajectories already established for these variables

Discovery of Seven Companions To Intermediate-Mass Stars With Extreme Mass Ratios in the Scorpius-Centaurus Association

We report the detection of seven low-mass companions to intermediate-mass stars (SpT B/A/F; M similar to 1.5-4.5M(circle dot)) in the Scorpius-Centaurus (Sco-Cen) Association using nonredundant aperture masking interferometry. Our newly detected objects have contrasts Delta L' approximate to 4-6, corresponding to masses as low as similar to 20 M-Jup and mass ratios of q approximate to 0.01-0.08, depending on the assumed age of the target stars. With projected separations rho approximate to 10-30 AU, our aperture masking detections sample an orbital region previously unprobed by conventional adaptive optics imaging of intermediate-mass Sco-Cen stars covering much larger orbital radii (similar to 30-3000 AU). At such orbital separations, these objects resemble higher-mass versions of the directly imaged planetary mass companions to the 10-30 Myr, intermediate-mass stars HR 8799, beta Pictoris, and HD 95086. These newly discovered companions span the brown dwarf desert, and their masses and orbital radii provide a new constraint on models of the Formation of low-mass stellar and substellar companions to intermediate-mass stars.NASA through the Sagan Fellowship ProgramNSF Astronomy and Astrophysics Postdoctoral Fellowship AST-1203023Clay FellowshipNASA through Hubble Fellowship 51257.01AURA, Inc., for NASA NAS 5-26555W. M. Keck FoundationAstronom

System thermal-hydraulic modelling of the phénix dissymmetric test benchmark

Phénix is a French pool-type sodium-cooled prototype reactor; before the definitive shutdown, occurred in 2009, a final set of experimental tests are carried out in order to increase the knowledge on the operation and the safety aspect of the pool-type liquid metal-cooled reactors. One of the experiments was the Dissymmetric End-of-Life Test which was selected for the validation benchmark activity in the frame of SESAME project. The computer code validation plays a key role in the safety assessment of the innovative nuclear reactors and the Phénix dissymmetric test provides useful experimental data to verify the computer codes capability in the asymmetric thermal-hydraulic behaviour into a pool-type liquid metal-cooled reactor. This paper shows the comparison of the outcomes obtained with six different System Thermal-Hydraulic (STH) codes: RELAP5-3D©, SPECTRA, ATHLET, SAS4A/SASSYS-1, ASTEC-Na and CATHARE. The nodalization scheme of the reactor was individually achieved by the participants; during the development of the thermal-hydraulic model, the pool nodalization methodology had a special attention in order to investigate the capability of the STH codes to reproduce the dissymmetric effects which occur in each loop and into pools, caused by the azimuthal asymmetry of the boundary conditions. The modelling methodology of the participants is discussed and the main results are compared in this paper to obtain useful guide lines for the future modelling of innovative liquid metal pool-type reactors

The Gravity Dual of the Ising Model

We evaluate the partition function of three dimensional theories of gravity in the quantum regime, where the AdS radius is Planck scale and the central charge is of order one. The contribution from the AdS vacuum sector can - with certain assumptions - be computed and equals the vacuum character of a minimal model CFT. The torus partition function is given by a sum over geometries which is finite and computable. For generic values of Newton's constant G and the AdS radius L the result has no Hilbert space interpretation, but in certain cases it agrees with the partition function of a known CFT. For example, the partition function of pure Einstein gravity with G=3L equals that of the Ising model, providing evidence that these theories are dual. We also present somewhat weaker evidence that the 3-state and tricritical Potts models are dual to pure higher spin theories of gravity based on SL(3) and E_6, respectively.Comment: 42 page

Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial

Objective: Physical activity is related to clinical outcomes, even after adjusting for body mass, but is rarely assessed in randomized clinical trials. Research design and methods: We conducted an observational analysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial, in which a total of 9306 people from 40 countries with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors were randomized to receive nateglinide or placebo, in a 2-by-2 factorial design with valsartan or placebo. All were asked to also participate in a detailed lifestyle modification programme and followed-up for a median of 6.4 years with progression to diabetes as a co-primary end point. Seven-day ambulatory activity was assessed at baseline using research-grade pedometers. We assessed whether the baseline amount of physical activity was related to subsequent development of diabetes in individuals with impaired glucose tolerance. Results: Pedometer data were obtained on 7118 participants and 35.0% developed diabetes. In an unadjusted analysis each 2000-step increment in the average number of daily steps, up to 10 000, was associated with a 5.5% lower risk of progression to diabetes (HR 0.95, 95%CI 0.92 to 0.97), with >6% relative risk reduction after adjustment. Conclusions: Physical activity should be measured objectively in pharmacologic trials as it is a significant but underappreciated contributor to diabetes outcomes. It should be a regular part of clinical practice as well. © 2018 Author(s) (or their employer(s).Peer reviewe