Is triple-positive serology for Epstein-Barr virus (VCA-IgG, VCA-IgM, EBNA-IgG) a specific feature of angioimmunoblastic T-cell lymphoma?

Purpose: We assessed the frequency of triple-positive serology (viral capsid antigen [VCA]-immunoglobulin G [IgG], VCA-immunoglobulin M, Epstein-Barr nuclear antigen-IgG) for Epstein-Barr virus (EBV) in a small number of patients with angioimmunoblastic T-cell lymphoma (AITL) at disease onset. Methods: Nine patients with newly diagnosed AITL were retrospectively enrolled in the present study. For all of them, EBV serology data were available. Results: Of 9 patients, 7 (77.7%) had a triple-positive serology (VCA-IgG, VCA-IgM, EBNA-IgG ) for EBV. These patients were characterized by bone marrow involvement, high incidence of thrombocytopenia, and poor prognosis according to Revised International Prognostic Index and Prognostic Index for Angioimmunoblastic T-cell Lymphoma scores. Conclusion: Assessment of both viremia and serology for EBV could be useful in patients with clinical and laboratory data suggesting lymphoma diagnosis; furthermore, although our data need to be validated in a larger cohort of patients, triple positivity for EBV serology might help to direct the diagnosis toward AITL

Anarchism in Arab literature: Radical Thought and its Influence on Art and Literature in Egypt and Syria in the First half of 20th Century

Předkládaná práce se zabývá vznikem a vývojem radikálního myšlení v Sýrii a Egyptě v první polovině 20. století a jeho interakcí s uměním a literaturou. Především se zaměřuje na vztah radikální levice a arabské obrody a na kontiunuitu tohoto myšlení ve vymezeném prostoru v první polovině 20. století. Dále setato práce zaměřuje na společné body radikálního směru arabské obrodys egyptským surrealistickým hnutím ve 30. a 40. letech 20. století. V závěru práce jsou tyto body zasazeny do širšího kulturně-literárního kontextu.The presented work is focused on the birth and evolution of radical thought in Syria and Egypt during the first half of 20th centrury and especially on it's interaction with art and literature. First of all it's focus is on the relation of Arab renaissance and radical left ideas and continuity of this thought in region under the study in the first half of 20th centrury. This work is as well focused on the common grounds of radical trends in Arab renaissance with Egyptian surrealist movement of the 30's and 40's. To this movement is dedicated final part of this work.Institute of Near Eastern and African StudiesÚstav Blízkého východu a AfrikyFilozofická fakultaFaculty of Art

Nationality in international investment arbitration

Nationality in international investment arbitration Abstract The subject of this rigorous thesis is the nationality in international investment arbitration. The objective of this thesis is to provide the insight into the issue of nationality in international investment disputes to the professional community and to introduce significant investment disputes regarding this topic. The paper is divided into six main parts. First chapter describes the international investment arbitration (dispute) in general. Second chapter is devoted to the definition of investor and to various principles that can be used to assess the nationality of investors. Third chapter looks at the nationality of investors from the perspective of Washington Treaty, whereas fourth chapter looks at the nationality from the perspective of Energy Charter Treaty. Fifth chapter introduces some significant bilateral investment treaties signed by Czech Republic and their approaches for defining the nationality of investors. Finally six chapter looks at some particular issues through case studies of arbitration tribunals' decisions.Státní příslušnost v mezinárodních investičních sporech Abstrakt Předmětem této rigorózní práce je státní příslušnost v mezinárodních investičních sporech. Cílem práce je poskytnout odborné veřejnosti náhled na problematiku státní příslušnosti v mezinárodních investičních sporech a přiblížit významné investiční spory týkající se této problematiky. Práce je rozdělena do šesti hlavních části. První kapitola popisuje mezinárodní investiční arbitráže (spory) obecně. Druhá kapitola je věnována definici investora a různým principům, které mohou být použity pro určení státní příslušnosti. Třetí kapitola nahlíží na státní příslušnost z pohledu Washingtonské úmluvy, zatímco čtvrtá kapitola na státní příslušnost z pohledu Smlouvy o energetické chartě. Pátá kapitola představuje některé významné bilaterální investiční dohody podepsané Českou republikou a jejich přístupy pro určení státní příslušnosti investorů. Na závěr šestá kapitola nahlíží na některé dílčí problémy prostřednictvím případových studií rozhodnutí rozhodčích tribunálů.Katedra obchodního právaDepartment of Business LawFaculty of LawPrávnická fakult

Film Audience and Film Culture in the City of Velvary

This bachelor thesis deals with the analysis of the film audience and film culture in the city of Velvary. The main goal is to reconstruct the history of the cinema with the help of historical documents and interviews with local residents. The second part of the thesis analyses film program. The thesis tries to look at the program throughout its structure, dates of the projections, audience attendance and ticket prices. The last part focuses on the questionnaire which helps to analyse the local spectator. The most important part of the research is to find out how the current spectator feels about the cinema. The result of this bachelor thesis is the history of a particular small town cinema, its program structure from 1960 to 1999 and the research of the current audience in the city of Velvary.Tato bakalářská práce pojednává o filmovém divákovi a filmové kultuře ve Velvarech. Nejdůležitější kulturní institucí ve městě bylo po většinu 20. století kino, proto je mu věnován největší prostor. Práce se snaží zrekonstruovat historii kina pomocí několika dochovaných dokumentů a rozhovorů s pamětníky. Další část má za úkol analyzovat program kina. Práce sleduje, jak byl program strukturován, kdy se promítalo a jak se vyvíjela divácká návštěvnost a cena vstupenek. Poslední část analyzuje na základě dotazníkového šetření, jak vypadá současný velvarský divák. Nejdůležitější částí výzkumu je vyhodnocení vztahu velvarských občanů k zavřenému kinu a filmovému promítání ve městě jako takovému. Výsledkem práce je historie maloměstského kina, jeho programová struktura od roku 1960 do roku 1999 minulého století a výzkum současného diváka ve Velvarech.Katedra filmových studiíFilm Studies DepartmentFaculty of ArtsFilozofická fakult

Energetics of apartment buildings

V této práci je vytvořený ucelený souhrn energetiky rodinných a bytových domů. V práci jsou podrobně popsány jednotlivé druhy zdrojů energie a jednotlivé druhy tepelných izolací pro rodinné a bytové domy. Další část práce se zabývá problematikou komunitní energetiky, jejím současným rozvojem v České republice a ve světě a její závislostí na legislativě a podpoře dané země. V závěru práce jsou jednotlivé varianty zdrojů energie a tepelných izolací pro rodinné a bytové domy vzájemně porovnány z pohledu ročních nákladů na vytápění a z pohledu kritérií ekonomické efektivnosti. Ekonomicky nejpříznivější varianty jsou dále srovnávány s variantou využití technologie řízeného větrání s rekuperací.In this thesis, a comprehensive summary of family and apartment houses energetics is created. The thesis describes the various types of energy sources and various types of thermal insulation for family and apartment buildings. The next part of the thesis addresses the issues of community energetics, its current development in the Czech Republic and in the world and its dependence on legislation and support of the country. At the end of the thesis, the individual variants of energy sources and thermal insulation for family and apartment houses are compared with each other in terms of annual heating costs and in terms of economic efficiency criteria. The most economically favorable variants are further compared with the variant of using controlled ventilation technology with recuperation

Intelligent installation in a family house

Tato práce se zabývá inteligentní elektroinstalací, především pak inteligentní elektroinstalací v rodinném domě. Práce je rozdělená na část teoretickou a praktickou. V teoretické části jsou popsány základní prvky inteligentní elektroinstalace, možnosti jejího využití v rodinném domě a prvky, pomocí kterých celý dům řídíme. Praktická část práce je věnována návrhu dvoupodlažního rodinného domu, včetně prováděcí projektové dokumentace a výkresů obsahujících rozvod elektroinstalace. Závěr práce je zaměřen na porovnání klasické a inteligentní elektroinstalace.This work deals with intelligent wiring, with the focus on intelligent wiring in a family house. The thesis is composed of a theoretical and a practical part. In the theoretical part, basic components of intelligent wiring are described, the possibilities of its use in a family house and the components through which the house is controlled. The main problem addressed in the practical part is the design of a two-storey family house, including the project documentation and the electrical wiring drawings. The conclusion of the thesis is dedicated to the comparison of classical and intelligent wiring

Role of mesenchymal stromal cell-derived extracellular vesicles in tumour microenvironment

Abstract Stromal cells, deriving from mesenchymal stromal cells (MSCs), are crucial component of tumour microenvironment and represent key regulators of tumour processes. MSCs can be recruited to the tumour environment and interact with many cellular elements, thus influencing tumour biology. Cell-to-cell communication is in part mediated by the release of extracellular vesicle (EVs). EVs can induce significant molecular changes in recipient cells, delivering bioactive molecules. In this review, we describe the MSC-derived EVs content and discuss their role in different processes related to cancer biology. Furthermore, we summarize chemical or biological EVs modifications aiming to develop more efficient antitumor therapies

Immunological characterization of multipotent mesenchymal stromal cells--The International Society for Cellular Therapy (ISCT) working proposal.

Disclosure of interests: The authors have no commercial, proprietary, or financial interest in the products or companies described in this article.International audienceCultured mesenchymal stromal cells (MSCs) possess immune regulatory properties and are already used for clinical purposes, although preclinical data (both in vitro and in vivo in animal models) are not always homogeneous and unequivocal. However, the various MSC-based clinical approaches to treat immunological diseases would be significantly validated and strengthened by using standardized immune assays aimed at obtaining shared, reproducible and consistent data. Thus, the MSC Committee of the International Society for Cellular Therapy has decided to put forward for general discussion a working proposal for a standardized approach based on a critical view of literature data

The Evolving Knowledge on T and NK Cells in Classic Hodgkin Lymphoma: Insights into Novel Subsets Populating the Immune Microenvironment

Classic Hodgkin lymphoma (cHL) is a unique lymphoid neoplasm characterized by extensive immune infiltrates surrounding rare malignant Hodgkin Reed-Sternberg (HRS) cells. Different subsets of T and NK cells have long been recognized in the cHL microenvironment, yet their distinct contribution to disease pathogenesis has remained enigmatic. Very recently, novel platforms for high dimensional analysis of immune cells, such as single-cell RNA sequencing and mass cytometry, have revealed unanticipated insights into the composition of T- and NK-cell compartments in cHL. Advances in imaging techniques have better defined specific T-helper subpopulations physically interacting with neoplastic cells. In addition, the identification of novel cytotoxic subsets with an exhausted phenotype, typically enriched in cHL milieu, is shedding light on previously unrecognized immune evasion mechanisms. This review examines the immunological features and the functional properties of T and NK subsets recently identified in the cHL microenvironment, highlighting their pathological interplay with HRS cells. We also discuss how this knowledge can be exploited to predict response to immunotherapy and to design novel strategies to improve PD-1 blockade efficacy

Management of Chronic Myeloid Leukemia in Advanced Phase

Management of chronic myeloid leukemia (CML) in advanced phases remains a challenge also in the era of tyrosine kinase inhibitors (TKIs) treatment. Cytogenetic clonal evolution and development of resistant mutations represent crucial events that limit the benefit of subsequent therapies in these patients. CML is diagnosed in accelerated (AP) or blast phase (BP) in <5% of patients, and the availability of effective treatments for chronic phase (CP) has dramatically reduced progressions on therapy. Due to smaller number of patients, few randomized studies are available in this setting and evidences are limited. Nevertheless, three main scenarios may be drawn: (a) patients diagnosed in AP are at higher risk of failure as compared to CP patients, but if they achieve optimal responses with frontline TKI treatment their outcome may be similarly favorable; (b) patients diagnosed in BP may be treated with TKI alone or with TKI together with conventional chemotherapy regimens, and subsequent transplant decisions should rely on kinetics of response and individual transplant risk; (c) patients in CP progressing under TKI treatment represent the most challenging population and they should be treated with alternative TKI according to the mutational profile, optional chemotherapy in BP patients, and transplant should be considered in suitable cases after return to second CP. Due to lack of validated and reliable markers to predict blast crisis and the still unsatisfactory results of treatments in this setting, prevention of progression by careful selection of frontline treatment in CP and early treatment intensification in non-optimal responders remains the main goal. Personalized evaluation of response kinetics could help in identifying patients at risk for progression