143 research outputs found

    Próba ukierunkowania rehabilitacji u pacjentów ze stwardnieniem rozsianym w zależności od typu klinicznego choroby = The attempt conditions for the rehabilitation of patients with multiple sclerosis, depending on the type of clinical disease

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    Garczyński Wojciech, Krajewski Stanisław. Próba ukierunkowania rehabilitacji u pacjentów ze stwardnieniem rozsianym w zależności od typu klinicznego choroby = The attempt conditions for the rehabilitation of patients with multiple sclerosis, depending on the type of clinical disease. Journal of Education, Health and Sport. 2016;6(7):35-58. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.56870http://ojs.ukw.edu.pl/index.php/johs/article/view/3655  The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 25.05.2016. Revised 25.06.2016. Accepted: 28.06.2016. Próba ukierunkowania rehabilitacji u pacjentów ze stwardnieniem rozsianym w zależności od typu klinicznego choroby The attempt conditions for the rehabilitation of patients with multiple sclerosis, depending on the type of clinical disease Wojciech Garczyński 1,2, Stanisław Krajewski 3,4 1 Wyższa Szkoła Edukacji i Terapii w Poznaniu, Wydział Studiów Edukacyjnych, ul. Grabowa 22, 61-473 Poznań2 Indywidualna Praktyka Fizjoterapeutyczna, ul. Biskupa Bandurskiego 71/17, 71-685 Szczecin3 Bydgoska Szkoła Wyższa ul. Unii Lubelskiej 4; 85-059 Bydgoszcz4 Klinika Neurochirurgii 10 Wojskowy Szpital Kliniczny z Polikliniką, ul. Powstańców Warszawy 5, 85-681 Bydgoszcz Autor korespondencyjny: dr n. o zdr. Wojciech GarczyńskiIndywidualna Praktyka Fizjoterapeutycznaul. Biskupa Bandurskiego 71/1771-685 [email protected] Słowa kluczowe: rehabilitacja, stwardnienie rozsiane. Key words: rehabilitation, multiple sclerosis.   WSTĘP. Stwardnienie rozsiane (łac. sclerosis multiplex, SM) jest to choroba o podłożu zapalno-demielinizacyjnym ośrodkowego układu nerwowego, w której dochodzi do wieloogniskowych zmian. Etiopatogeneza związana jest z uwarunkowaniami genetycznymi i immunologicznymi. Stwardnienie rozsiane może mieć przebieg z rzutami lub bez. Forma kliniczna pierwotnie postępująca (PPMS) stwardnienia rozsianego występuje bez rzutów, pozostałe formy kliniczne: rzutowo – remisyjna (RRMS), wtórnie postępująca (SPMS) i postępująco – nawracająca (PRMS) charakteryzują się pojawianiem się rzutów choroby, forma łagodna (BNMS) może występować bez rzutów.CEL BADAŃ. Głównym celem podjętych badań było poszukiwanie zależności pomiędzy zróżnicowaniem funkcji fizycznych chorych na stwardnienie rozsiane a typem klinicznym schorzenia. Ewentualne znalezienie takich zależności w konsekwencji pozwoliłoby na wczesne ukierunkowanie procesu rehabilitacji dostosowanej do potrzeb pacjentów z określonym typem klinicznym  choroby.MATERIAŁ I METODA. W badaniu wzięło udział 313 osób ze zdiagnozowanym stwardnieniem rozsianym, przebywających na czterotygodniowych turnusach rehabilitacyjnych w Centrum Rehabilitacji dla Osób Chorych na Stwardnienie Rozsiane im. Jana Pawła II w Bornym Sulinowie. Zastosowano metodę sondażu diagnostycznego z wykorzystaniem standaryzowanych kwestionariuszy, typowych do oceny funkcji u chorych na stwardnienie rozsiane (EDSS, MFIS, MDST, HADS, EQUI – SCAL). Do obliczeń statystycznych wykorzystano program Statistica 10 firmy StatSoft.WYNIKI. Uzyskano statystycznie istotne różnice w wieku zachorowania na stwardnienie rozsiane oraz w średnim czasie trwania choroby z podziałem na formy kliniczne (odpowiednio p<0,001 i p<0,01). Na podstawie testu Kruskala - Wallisa stwierdzono istotne statystycznie różnice w poziomie niewydolności ruchowej - EDSS (p<0,001), zmęczenia – MFIS (p<0,05), równowagi – EQUI SCALE (p<0,001) i niesprawności – MDST (p<0,01) w typach klinicznych stwardnienia rozsianego.WNIOSKI. 1. Poziom zmęczenia, zakres zaburzeń równowagi, poziom niewydolności ruchowej oraz niesprawności zależą od typu klinicznego SM. 2. Poziom objawów lękowych i depresyjnych nie wykazuje zróżnicowania pod względem typu klinicznego SM. 3. Pomimo występowania pewnego zróżnicowania poziomu wybranych funkcji fizycznych i społecznych zależnie od typu SM, trudnym wydaje się ukierunkowanie rehabilitacji w oparciu o te założenia.   INTRODUCTION. Multiple sclerosis (eng. Multiple sclerosis, MS) is an inflammatory-demyelinating disease of the central nervous system, wherein the multifocal changes occur. Etiopathogenesis is related to genetics and immune. Lesions are characterized by rapid progression and are mainly found in the white matter, brainstem, cerebellum, spinal cord and optic nerve. In remission, remyelination occurs, following which the inflammation subsides. Multiple sclerosis can run with or without relapses. Clinical form of primary progressive (PPMS), multiple sclerosis occurring without relapses, other clinical forms: relapsing - remitting (RRMS), secondary progressive (SPMS) and progressive - relapsing (PRMS) are characterized by the appearance of relapses, a form of benign (BNMS) may be present without relapses.OBJECTIVES. The main objective of this study was to examine correlations between the diversity of physical and social functions in patients with multiple sclerosis and the type and form of the disease. Possible to find such relations, in consequence,  would enable an early orientation of rehabilitation process for needs of patients with a particular type and form of the disease.MATERIAL AND METHODS. The study involved 313 patients (215 women and 98 men) diagnosed with multiple sclerosis staying on the four-week rehabilitation courses at the Pope John Paul II Center of Rehabilitation for People with Multiple Sclerosis in Borne Sulinowo. The method of diagnostic survey, based on a survey technique using standardized scales and questionnaires to assess the typical functions in patients with multiple sclerosis (EDSS, MFIS, MDST, HADS, EQUI - SCAL). For the statistical calculation StatSoft Statistica 10 was used.RESULTS. On the basis of the Kruskal – Wallis test statistically significant differences in the level of physical failure were found - EDSS (p <0.001), fatigue - MFIS (p <0.05), balance - EQUI SCALE (p <0.001) and disability - MDST (p <0.01) in clinical forms of multiple sclerosis.CONCLUSIONS. 1. The level of fatigue, imbalances, motor failure experienced by the patient depends on the clinical form of MS and shows no variation with respect to the type of disease. 2. Level of anxiety and depression symptoms does not have diversity in terms of form of multiple sclerosis. 3. Despite the prevalence of certain differentiation in some of the physical and social functions depending on the form and type of multiple sclerosis, it seems difficult to orientate rehabilitation based on these assumptions. It seems more important to individualize the process based on the nature and pace of the disease and taking into account the current patient's symptoms

    Granulomatosis With Polyangiitis in Otolaryngologist Practice: A Review of Current Knowledge

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    Granulomatosis with polyangiitis (GPA) is an idiopathic vasculitis of medium and small arteries, characterized by necrotizing granulomatous inflammation. GPA typically affects upper and lower respiratory tract with coexisting glomerulonephritis. This disease is generally characterized by antineutrophil cytoplasm antibodies (ANCA), nevertheless, there are rare cases with negative ANCA. GPA affects people at any age, with predominance of the sixth and seventh decade of life. In 80%–95% of the patients the first symptoms of GPA are otorhinolaryngological manifestations of head and neck including nose/sinuses, ears, eyes, larynx/trachea, oral cavity, and salivary glands. Diagnosis of GPA is based on Criteria of the American College of Rheumatology. In clinical practice diagnosis, the presence of distinctive ANCA antibodies and biopsy of affected organ are crucial. GPA must be differentiated from neoplastic, infectious or inflammatory ulcerative lesions of the head and neck. The standard treatment procedure is divided into two essential phases, induction and maintenance. The induction phase is based on combination of systemic corticosteroid and immunosuppressant therapy, whereas the maintenance phase comprises corticosteroids and azathioprine/methotrexate supplementation. Surgical treatment ought to be considered for patients who are not responding to pharmacotherapy

    Thoraco-omphalopagus twins: different perinatal circumstances, different outcome

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    Two pairs of omphalopagus twins were encountered at the Polish Mother's Health Institution in Lodz, Poland during the past 15 years. In the first set the prenatal diagnosis was not established and the delivery of the twins in a regional hospital was a complete surprise. Both babies died. In the second case the conjoined twins were diagnosed prenatally, surgical separation was successful, and both twins survived. The prenatal identification of conjoined twins is of cardinal importance for the planning of delivery and possible separation

    Automatyka pożarowa budynku w cyklu jego życia – metody weryfikacji działania, problemy z rozbudową systemów

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    This article presents the issues with the marketing of construction products that are part of fire automation of a building. The issues in marketing of the newest solutions are localised already within the testing process and the slow process of updating current standards. Also mounting the construction product bring new challenges – authors present a method of hot smoke testing, that allows for a quick and reliable assesment of system cooperation, also in the life of the building.W artykule przedstawiono problematykę wprowadzania do obrotu wyrobów budowlanych stanowiących elementy automatyki pożarowej. Problemy z wprowadzaniem do obrotu nowoczesnych rozwiązań zlokalizowano już w samym procesie badawczym oraz powolnej aktualizacji norm wyrobu. Także zastosowanie wyrobu w samym budynku przysparza trudności – autorzy przedstawiają zatem metodę gorącego dymu, pozwalającą na rzetelną i szybką ocenę tego współdziałania, także w trakcie użytkowania obiektu

    Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complex

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    Homologous recombination DNA repair requires double-strand break resection by helicase–nuclease enzymes. The crystal structure of bacterial AddAB in complex with DNA substrates shows that it employs an inactive helicase site to recognize ‘Chi' recombination hotspot sequences that regulate resection

    The Measurement of Territorial Differences in the Information Society

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    Glutamine synthetase (GS, EC 6.3.1.2; also known as γ-glutamyl:ammonia ligase) catalyzes the ATP-dependent condensation of glutamate and ammonia to form glutamine. The enzyme has essential roles in different tissues and species, which have led to its consideration as a drug or an herbicide target. In this article, we describe studies aimed at the discovery of new antimicrobial agents targeting Mycobacterium tuberculosis, the causative pathogen of tuberculosis. A number of distinct classes of GS inhibitors with an IC50 of micromolar value or better were identified via high-throughput screening. A commercially available purine analogue similar to one of the clusters identified (the diketopurines), 1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-8-morpholin-4-yl-purine-2,6-dione, was also shown to inhibit the enzyme, with a measured IC50 of 2.5 ± 0.4 μM. Two X-ray structures are presented: one is a complex of the enzyme with the purine analogue alone (2.55-Å resolution), and the other includes the compound together with methionine sulfoximine phosphate, magnesium and phosphate (2.2-Å resolution). The former represents a relaxed, inactive conformation of the enzyme, while the latter is a taut, active one. These structures show that the compound binds at the same position in the nucleotide site, regardless of the conformational state. The ATP-binding site of the human enzyme differs substantially, explaining why it has an ∼ 60-fold lower affinity for this compound than the bacterial GS. As part of this work, we devised a new synthetic procedure for generating l-(SR)-methionine sulfoximine phosphate from l-(SR)-methionine sulfoximine, which will facilitate future investigations of novel GS inhibitors

    Comparative analysis of GOLPH3 expression in lymph node-positive prostate cancer: immunohistochemistry staining patterns and clinical significance

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    IntroductionProstate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Lymph node metastasis is a poor prognostic factor for PCa. Previous studies have found that Golgi phosphoprotein 3 (GOLPH3) is overexpressed in various cancers, including PCa. We examined GOLPH3 expression in PCa cells from primary tumor and, as the first, also in metastatic lymph nodes to assess its potential as a new risk factor for PCa progression.MethodsThe study included 78 patients diagnosed with lymph node-positive PCa confirmed in the postoperative material. All the patients underwent radical prostatectomy (RP) with extended lymphadenectomy. The clinical data of the patients were retrospectively analyzed, and their histopathological specimens were selected for further analysis. Immunohistochemistry (IHC) staining was performed and the expression of GOLPH3 was assessed by an experienced uropathologist using an immunoreactive scale (IRS). A correlational analysis of the obtained data with the clinicopathological data of patients was performed.ResultsA positive IHC reaction for GOLPH3 was observed in all samples. IRS score for GOLPH3 expression was higher in the metastatic lymph nodes than in the prostate (not statistically significant; p=0.056). Several significant correlations were identified in connection with GOLPH3 expression levels in the prostate and metastatic lymph node tissues. No significant correlations were found between GOLPH3 expression and patient characteristics (e.g. BMI, EAU risk group, or preoperative PSA level), pathological features, or postoperative outcomes. However, we found that lymphovascular invasion (LVI) tended to be more common in patients with a higher percentage of GOLPH3-positive cells (p=0.02). We also found a positive association between the intensity of GOLPH3 staining in metastatic lymph nodes and the EAU classification. Finally, we found a significant negative correlation between the GOLPH3 expression and the efficacy of RP – the higher the expression of GOLPH3, the lower the efficacy of RP was (p<0.05).ConclusionGOLPH3 is expressed in both prostate and metastatic lymph nodes, with higher expression in metastatic lymph nodes. High GOLPH3 expression was associated with the occurrence of LVI, higher-risk group in the EAU classification, and lower efficacy of the RP, but there was no significant correlation with other pathological features or postoperative outcomes
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