Evaluating time-lapse borehole gravity for CO2 plume detection at SECARB Cranfield

Bureau of Economic Geolog

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases

The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects. This document: 1) summarises the protocols and procedures used in published studies focusing on incremental CPET in chronic lung conditions; 2) presents standard incremental protocols for CPET on a stationary cycle ergometer and a treadmill; and 3) provides patients’ perspectives on CPET obtained through an online survey supported by the European Lung Foundation. We systematically reviewed published studies obtained from EMBASE, Medline, Scopus, Web of Science and the Cochrane Library from inception to January 2017. Of 7914 identified studies, 595 studies with 26 523 subjects were included. The literature supports a test protocol with a resting phase lasting at least 3 min, a 3-min unloaded phase, and an 8- to 12-min incremental phase with work rate increased linearly at least every minute, followed by a recovery phase of at least 2–3 min. Patients responding to the survey (n=295) perceived CPET as highly beneficial for their diagnostic assessment and informed the Task Force consensus. Future research should focus on the individualised estimation of optimal work rate increments across different lung diseases, and the collection of robust normative data.The document facilitates standardisation of conducting, reporting and interpreting cardiopulmonary exercise tests in chronic lung diseases for comparison of reference data, multi-centre studies and assessment of interventional efficacy. http://bit.ly/31SXeB

Upholding social hierarchies: Social Dominance Orientation moderates the link between (intergroup) conspiracy exposure and violent extremism

Across two experimental studies, we explored whether exposure to intergroup conspiracy theories can increase violent reactions towards targeted groups. We also examined how ideological attitudes may moderate the effect. In Study 1 (N = 160, pre-registered), we found that exposure to immigrant conspiracy theories (vs control) increased the willingness to use violence for those who reported higher Social Dominance Orientation (SDO) and Right-Wing Authoritarianism (RWA). Study 2 (N = 211, pre-registered) sought to extend these results by focusing on a specific target: Muslim immigrants. Exposure to Muslim immigrant conspiracy theories (vs control) increased motivation and willingness to use violence for those with higher SDO (but not RWA). These findings showcase how exposure to intergroup conspiracy theories and violent reactions are conditional on specific ideological attitudes. Thus, when considering interventions, we argue that it is crucial to consider the role of ideological worldviews when seeking to combat conspiracy-inspired violence

Upholding social hierarchies: Social Dominance Orientation moderates the link between (intergroup) conspiracy exposure and violent extremism

Across two experimental studies, we explored whether exposure to intergroup conspiracy theories can increase violent reactions towards targeted groups. We also examined how ideological attitudes may moderate the effect. In Study 1 (N = 160, pre-registered), we found that exposure to immigrant conspiracy theories (vs control) increased the willingness to use violence for those who reported higher Social Dominance Orientation (SDO) and Right-Wing Authoritarianism (RWA). Study 2 (N = 211, pre-registered) sought to extend these results by focusing on a specific target: Muslim immigrants. Exposure to Muslim immigrant conspiracy theories (vs control) increased motivation and willingness to use violence for those with higher SDO (but not RWA). These findings showcase how exposure to intergroup conspiracy theories and violent reactions are conditional on specific ideological attitudes. Thus, when considering interventions, we argue that it is crucial to consider the role of ideological worldviews when seeking to combat conspiracy-inspired violence

Seismic Characterization of a Landslide Complex: A Case History from Majes, Peru

Seismic characterization of landslides offers the potential for developing high-resolution models on subsurface shear-wave velocity profile. However, seismic methods based on reflection processing are challenging to apply in such scenarios as a consequence of the disturbance to the often well-defined structural and stratigraphic layering by the landslide process itself. We evaluate the use of alternative seismic characterization methods based on elastic full waveform inversion (E-FWI) to probe the subsurface of a landslide complex in Majes, southern Peru, where recent agricultural development and irrigation activities have altered the hydrology and groundwater table and are thought to have contributed to increased regional landslide activities that present continuing sustainability community development challenges. We apply E-FWI to a 2D near-surface seismic data set for the purpose of better understanding the subsurface in the vicinity of a recent landslide location. We use seismic first-arrival travel-time tomography to generate the inputs required for E-FWI to generate the final high-resolution 2D compressional- and shear-wave (P- and S-wave) velocity models. At distances greater than 140 m from the cliff, the inverted models show a predominantly vertically stratified velocity structure with a low-velocity near-surface layer between 5–15 m depth. At distances closer than 140 m from the cliff, though, the models exhibit significantly reduced shear-wave velocities, stronger heterogeneity, and localized shorter wavelength structure in the top 20 m. These observations are consistent with those expected for a recent landslide complex; however, follow-on geotechnical analysis is required to confirm these assertions. Overall, the E-FWI seismic approach may be helpful for future landslide characterization projects and, when augmented with additional geophysical and geotechnical analyses, may allow for improved understanding of the hydrogeophysical properties associated with suspected ground-water-driven landslide activity

Enumeration of Mycobacterium leprae Using Real-Time PCR

Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a real-time PCR assay for quantifying M. leprae DNA in biological samples. Primers were identified to amplify a shared region of the multicopy repeat sequence (RLEP) specific to M. leprae and tested for sensitivity and specificity in the TaqMan format. The assay was specific for M. leprae and able to detect 10 fg of purified M. leprae DNA, or approximately 300 bacteria in infected tissues. We used the RLEP TaqMan PCR to assess the short and long-term growth results of M. leprae in foot pad tissues obtained from conventional mice, a gene knock-out mouse strain, athymic nude mice, as well as from reticuloendothelial tissues of M. leprae–infected nine-banded armadillos. We found excellent correlative results between estimates from RLEP TaqMan PCR and direct microscopic counting (combined r = 0.98). The RLEP TaqMan PCR permitted rapid analysis of batch samples with high reproducibility and is especially valuable for detection of low numbers of bacilli. Molecular enumeration is a rapid, objective and highly reproducible means to estimate the numbers of M. leprae in tissues, and application of the technique can facilitate work with this agent in many laboratories

Pinpointing the source of a lunar meteorite: implications for the evolution of the moon

The lunar meteorite Sayh al Uhaymir 169 consists of an impact melt breccia extremely enriched with potassium, rare earth elements, and phosphorus [thorium, 32.7 parts per million (ppm); uranium, 8.6 ppm; potassium oxide, 0.54 weight percent], and adherent regolith. The isotope systematics of the meteorite record four lunar impact events at 3909 ± 13 million years ago (Ma), 2800 Ma, 200 Ma, and <0.34 Ma, and collision with Earth sometime after 9.7 ± 1.3 thousand years ago. With these data, we can link the impact-melt breccia to Imbrium and pinpoint the source region of the meteorite to the Lalande impact crater

Hydrologic Analysis of an Intensively Irrigated Area in Southern Peru Using a Crop-Field Scale Framework

Majes is one of the largest agricultural areas in the Arequipa region (southern Peru). Low seasonal precipitation and increasing water demands for agricultural irrigation, industry, and human consumption have made water supply projections a major concern. Agricultural development is becoming more extensive in this dry, sunny climate where crops can be grown year-round. However, because this type of project usually involves significant perturbations to the regional water cycle, understanding the effects of irrigation on local hydrology is crucial. Based on the watershed-scale Soil and Water Assessment Tool (SWAT), this investigation focuses on the impacts of intensive irrigation on hydrological responses in the Majes region. This study is unique because we allow for crop-field scale input within our regional-scale model to provide information at this smaller scale, which is important to inform local stakeholders and decision makers. Each hydrologic response unit (HRU) was generated to represent an individual crop field, so that management practices could be applied according to real-world scenarios. The management file of each HRU was modified to include different operation schedules for crop rotation, irrigation, harvest, and tillage. The model was calibrated and validated against monthly observed stream discharge during the 2009–2020 period. Additionally, evapotranspiration, irrigation water volume, and daily stream discharge downstream of the local river (Siguas) were used to verify the model performance. A total of 49 sub-basins and 4222 HRUs were created, with 3000 HRUs designated to represent individual crop fields. The simulation results revealed that infiltration from agricultural activities in Majes represents the majority of annual groundwater return flow, which makes a substantial contribution to streamflow downstream of the Siguas River. Simulations also suggested that groundwater flow processes and the interactions between surface and groundwater have a major impact on the water balance of the study area. Additionally, climate variability had a higher impact on surface runoff than on groundwater return flow, illustrating that the groundwater component in the study area is important for future water resources resiliency under expected climate change scenarios. Finally, there is a need to perform a follow-up implementation to provide a guideline for decision-makers to assess future sustainable water resources management under varying climatic conditions for this arid irrigated system

Hydrologic Analysis of an Intensively Irrigated Area in Southern Peru Using a Crop-Field Scale Framework

Majes is one of the largest agricultural areas in the Arequipa region (southern Peru). Low seasonal precipitation and increasing water demands for agricultural irrigation, industry, and human consumption have made water supply projections a major concern. Agricultural development is becoming more extensive in this dry, sunny climate where crops can be grown year-round. However, because this type of project usually involves significant perturbations to the regional water cycle, understanding the effects of irrigation on local hydrology is crucial. Based on the watershed-scale Soil and Water Assessment Tool (SWAT), this investigation focuses on the impacts of intensive irrigation on hydrological responses in the Majes region. This study is unique because we allow for crop-field scale input within our regional-scale model to provide information at this smaller scale, which is important to inform local stakeholders and decision makers. Each hydrologic response unit (HRU) was generated to represent an individual crop field, so that management practices could be applied according to real-world scenarios. The management file of each HRU was modified to include different operation schedules for crop rotation, irrigation, harvest, and tillage. The model was calibrated and validated against monthly observed stream discharge during the 2009–2020 period. Additionally, evapotranspiration, irrigation water volume, and daily stream discharge downstream of the local river (Siguas) were used to verify the model performance. A total of 49 sub-basins and 4222 HRUs were created, with 3000 HRUs designated to represent individual crop fields. The simulation results revealed that infiltration from agricultural activities in Majes represents the majority of annual groundwater return flow, which makes a substantial contribution to streamflow downstream of the Siguas River. Simulations also suggested that groundwater flow processes and the interactions between surface and groundwater have a major impact on the water balance of the study area. Additionally, climate variability had a higher impact on surface runoff than on groundwater return flow, illustrating that the groundwater component in the study area is important for future water resources resiliency under expected climate change scenarios. Finally, there is a need to perform a follow-up implementation to provide a guideline for decision-makers to assess future sustainable water resources management under varying climatic conditions for this arid irrigated system