922 research outputs found
Serum Neutrophil Gelatinase-Associated Lipocalin - A Sensitive Novel Marker of Renal Impairment in Liver Cirrhosis?
Understanding and predicting size selection in diamond-mesh cod ends for danish seining: A study based on sea trials and computer simulations
Danish seining is an important fishing method used to harvest demersal species. Knowledge about the size selectivity of different demersal species with this type of fishing gear is therefore of importance for managing the exploitation of marine resources. However, there are only limited data on size selection in cod ends in this fishery. Sea trials were therefore carried out to collect size selectivity data for Atlantic Cod Gadus morhua, Haddock Melanogrammus aeglefinus, and Witch Flounder Glyptocephalus cynoglossus for a diamond-mesh cod end. For all three species, the data were best described by a double logistic selection curve, implying that two different size selection processes occur in the cod end. The double selection process could be explained by an additional selection process occurring through slack meshes. The results imply that the escapement of 46% and 34% of the larger Atlantic Cod and Haddock (those above 48 cm), respectively, would be through wide-open or slack meshes. Since these mesh states are only likely to be present in the latest stage of the fishing process (e.g., when the cod end is near the surface), a large fraction of the bigger fish probably escaped near the surface, which might influence their likelihood of survival. Furthermore, based on the models established for explaining the experimental size selection, we were able to predict the effect of changing the mesh size on cod end size selection in the Danish seine fishery
When is enough, enough? Quantifying trade-offs between information quality and sampling effort for fishing gear selectivity data
There is general pressure throughout the world’s fisheries for the industry to have greater involvement not only in the development of fishing gears but also in the testing and documentation of their effect. In the European Union, the Common Fisheries Policy of 2013, together with the proposed reform of the technical measures regulation, highlights the need for greater flexibility in fisheries through increased stakeholder involvement. To achieve this flexibility, there is a need for additional fishing gears available to the fishermen. A way to facilitate this is to have the industry take part in the development and testing of fishing gears, as well as collect data on their performance. However, to have a successful industry-collected data programme, fishermen have to be able to collect data on the length of a portion of the catch. In this study, we determine how many individuals need to be measured to correctly evaluate the relative selective performance of a new gear compared to a standard gear. The evaluation was carried out by analysing catch ratio curves, their associated uncertainties, and the trade-offs between uncertainties and sampling effort. Results show that with relatively small sample sizes (500 to 1000 individuals) it is possible to correctly evaluate the performance of a gear for a given species. By having the industry develop and test their own gears, as well as being involved in the collection of data, the number of potential gear solutions available to address the different issues emerging in the fisheries is increased
Influence of twin and multi-rig trawl systems on CPUE in the Danish Norway lobster (Nephrops norvegicus) fishery
Katalog over selektive redskaber afprøvet i dansk fiskeri:En guide til bedre at undgå uønsket fangst
FLEXSELECT: counter-herding device to reduce bycatch in crustacean trawl fisheries
FLEXSELECT is a simple counter-herding device which aims at reducing the bycatch of fish by scaring them away from the trawl path without affecting the catches of the target species. FLEXSELECT was tested in the Norway lobster (Nephrops norvegicus) directed trawl fishery, as this includes bycatch of both roundfish and flatfish. Length-based data were collected for Nephrops, four roundfish species (cod, haddock, whiting and hake) and two flatfish species (plaice and lemon sole) and length-based catch comparisons performed. No significant effect on the target species, Nephrops, was detected, whereas a reduction of 39% (CI: 29-46 %) was obtained for the overall number of fish. Catches of all the six fish species examined were significantly reduced by FLEXSELECT, with the efficiency varying considerably among species and over length classes. No significant diel differences were found for either roundfish or flatfish species. FLEXSELECT prevents bycatch species from interacting with the trawl, thus most likely enhancing their survival and fitness. Moreover, its fast attachment system makes FLEXSELECT a flexible tool, adaptable to different fisheries and catch goals.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Significant individual variation between pathologists in the evaluation of colon cancer specimens after complete mesocolic excision
Background: After the introduction of complete mesocolic excision, a new pathological evaluation of the resected colon cancer specimen was introduced. This concept has quickly gained acceptance and is often used to compare surgical quality. The grading of colon cancer specimens is likely to depend on both surgical quality and the training of the pathologist. Objective: The purpose of this study was to validate the principles of the pathological evaluation of colon cancer specimens. Design: This was an exploratory study. Settings: The study was conducted in Aarhus, Denmark, and Leeds, United Kingdom. Patients: Colon cancers specimens were used. Main outcome measures: The agreement of gradings between participants was of interest. Four specialist GI pathologists and 2 abdominal surgeons evaluated 2 rounds of colon cancer specimens, each at 2 separate time points. Each round contained 50 specimens. After the first round, a protocol of detailed principles for the grading procedure was agreed on. Results from an experienced pathologist were considered as the reference results. Results: In the first round, the distribution of gradings between participants showed substantial variation. In the second round, the variation was reduced. Intraobserver agreement was mostly fair to good, whereas interobserver agreement was frequently poor. This did not significantly change from round 1 to round 2. Limitations: The small sample size of 100 specimens provided a very small number of specimens resected in the muscularis propria plane, which renders the evaluation of this group potentially unreliable. The evaluations were made on photos and not on fresh specimens. Conclusions: This study demonstrates significant variation in the pathological evaluation of colon cancer specimens. It demonstrates that it cannot be used in clinical studies, and care should be taken when comparing results between different hospitals
Algorithms for early detection of silent liver fibrosis in the primary care setting - a scoping review
Introduction
Fatty liver disease affects almost 30% of the adult population worldwide. Most patients are asymptomatic, and there is not a linear relationship between exposure to risk factors and the risk of developing fibrosis. The combination of a very large, asymptomatic risk population where only a few percent will develop life-threatening liver disease is a growing diagnostic challenge for the health services. Accurate fibrosis assessment in primary care is limited by poor correlation with liver blood tests and low availability of elastography. Non-invasive tests are promising tools, but little is known about their diagnostic accuracy in low-risk populations.
Areas covered
A scoping review was conducted to identify articles that focused on the current use of biomarkers and algorithms in primary care for the detection of patients with fatty liver disease in need of referral for further work-up.
Expert opinion
Currently available algorithms for targeted screening for liver fibrosis perform better than the individual routine liver blood tests or liver ultrasonography. However, primary care physicians urgently need algorithms with even higher diagnostic accuracies than what is available today. The main limitation of the existing widely accessible algorithms, such as the FIB-4, is the large number of false-positive tests, resulting in overdiagnosis and futile referrals to secondary care.publishedVersio
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