A Class of Distribution Function Processes Which Have Derivatives

1 online resource (PDF, 5 pages

A Fluctuation Theorem and Distribution Free Test

1 online resource (PDF, 4 pages

Theology, News and Notes - Vol. 16, No. 02

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1038/thumbnail.jp

A Multivariate Test of the Null Hypothesis That Two Populations Do Not Differ in the Direction of Their Mean Vectors

1 online resource (PDF, 6 pages

An Application Of Multivariate Analysis To Some Tranquilzer Comparison Experiments

1 online resource (PDF, 13 pages

Theology, News and Notes - Vol. 23, No. 01

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1056/thumbnail.jp

Information Literacy Competencies and Copyright in Brazilian Higher Education Institutions

RESUMEN: La competencia informacional o alfabetización informacional (COINFO/ALFIN) es la evolución natural de la antigua formación de usuarios en las bibliotecas adaptada a los nuevos tiempos, donde la tecnología juega un importante papel. Por su parte, el uso ético y legal de la información es una de las competencias que conforman este tipo de formación dentro de los estándares internacionales COINFO/ALFIN. Con el objetivo de conocer la repercusión del uso ético y legal de la información dentro de estos planes formativos de las bibliotecas de educación superior en Brasil, se diseñó un breve cuestionario en línea para averiguar si poseen un plan de COINFO o de formación de usuarios, si dentro de los planes se trata el uso ético y legal de la información y los derechos de autor, en qué consiste esta información cuando se produce, y si las bibliotecas disponen de personal preparado para atender dudas sobre estas cuestiones. De los resultados se desprende que las bibliotecas de educación superior en Brasil aún tienen un largo camino por recorrer en materia de COINFO. No todas tienen planes adecuados para sus usuarios y entre los que sí tienen, cuando se habla sobre derechos de autor, el discurso se centra en los aspectos sancionadores de los mismos, sin dar cabida a la formación que permita saber a autores y usuarios qué derechos tienen, cómo usar las obras de terceros o cómo pueden compartir sus obras, entre otros.ABSTRACT: Information literacy (IL) is the natural evolution of the old “user training” in libraries, adapted to the new times where technology plays an important role. Legal and ethical use of information is one of the competencies incorporated in important international standards of IL. In order to know the impact of the ethical and legal use of information within these training plans in libraries of higher education entities in Brazil, a brief online questionnaire was designed and executed. The questionnaire aimed to research the existence of plans for IL and/or user training , the ethical and legal use of information, copyright, what kind of information they show, and the availability of staff members at libraries to address concerns on these issues. The results show that libraries of higher education entities in Brazil still have a lot of work to do in our area. Not all of them have adequate education plans for their users and those who do have them, and also include some information about copyright, the discourse focuses on disciplinary aspects, without training authors nor users about their rights, how to use the work of others, how to share their own work, amongst others

Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial

IMPORTANCE: A safe and effective treatment for recurrent Clostridioides difficile infection (CDI) is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted microbiome, which promotes spore germination and infection recurrence. OBJECTIVES: To evaluate the safety and rate of CDI recurrence after administration of investigational microbiome therapeutic SER-109 through 24 weeks. DESIGN, SETTING, AND PARTICIPANTS: This phase 3, single-arm, open-label trial (ECOSPOR IV) was conducted at 72 US and Canadian outpatient sites from October 2017 to April 2022. Adults aged 18 years or older with recurrent CDI were enrolled in 2 cohorts: (1) rollover patients from the ECOSPOR III trial who had CDI recurrence diagnosed by toxin enzyme immunoassay (EIA) and (2) patients with at least 1 CDI recurrence (diagnosed by polymerase chain reaction [PCR] or toxin EIA), inclusive of their acute infection at study entry. INTERVENTIONS: SER-109 given orally as 4 capsules daily for 3 days following symptom resolution after antibiotic treatment for CDI. MAIN OUTCOMES AND MEASURES: The main outcomes were safety, measured as the rate of treatment-emergent adverse events (TEAEs) in all patients receiving any amount of SER-109, and cumulative rates of recurrent CDI (toxin-positive diarrhea requiring treatment) through week 24 in the intent-to-treat population. RESULTS: Of 351 patients screened, 263 were enrolled (180 [68.4%] female; mean [SD] age, 64.0 [15.7] years); 29 were in cohort 1 and 234 in cohort 2. Seventy-seven patients (29.3%) were enrolled with their first CDI recurrence. Overall, 141 patients (53.6%) had TEAEs, which were mostly mild to moderate and gastrointestinal. There were 8 deaths (3.0%) and 33 patients (12.5%) with serious TEAEs; none were considered treatment related by the investigators. Overall, 23 patients (8.7%; 95% CI, 5.6%-12.8%) had recurrent CDI at week 8 (4 of 29 [13.8%; 95% CI, 3.9%-31.7%] in cohort 1 and 19 of 234 [8.1%; 95% CI, 5.0%-12.4%] in cohort 2), and recurrent CDI rates remained low through 24 weeks (36 patients [13.7%; 95% CI, 9.8%-18.4%]). At week 8, recurrent CDI rates in patients with a first recurrence were similarly low (5 of 77 [6.5%; 95% CI, 2.1%-14.5%]) as in patients with 2 or more recurrences (18 of 186 [9.7%; 95% CI, 5.8%-14.9%]). Analyses by select baseline characteristics showed consistently low recurrent CDI rates in patients younger than 65 years vs 65 years or older (5 of 126 [4.0%; 95% CI, 1.3%-9.0%] vs 18 of 137 [13.1%; 95% CI, 8.0%-20.0%]) and patients enrolled based on positive PCR results (3 of 69 [4.3%; 95% CI, 0.9%-12.2%]) vs those with positive toxin EIA results (20 of 192 [10.4%; 95% CI, 6.5%-15.6%]). CONCLUSIONS AND RELEVANCE: In this trial, oral SER-109 was well tolerated in a patient population with recurrent CDI and prevalent comorbidities. The rate of recurrent CDI was low regardless of the number of prior recurrences, demographics, or diagnostic approach, supporting the beneficial impact of SER-109 for patients with CDI. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03183141