330 research outputs found
A multimission three-axis stabilized spacecraft flight dynamics ground support system
The Multimission Three-Axis Stabilized Spacecraft (MTASS) Flight Dynamics Support System (FDSS) has been developed in an effort to minimize the costs of ground support systems. Unlike single-purpose ground support systems, which attempt to reduce costs by reusing software specifically developed for previous missions, the multimission support system is an intermediate step in the progression to a fully generalized mission support system in which numerous missions may be served by one general system. The benefits of multimission attitude ground support systems extend not only to the software design and coding process, but to the entire system environment, from specification through testing, simulation, operations, and maintenance. This paper reports the application of an MTASS FDSS to multiple scientific satellite missions. The satellites are the Upper Atmosphere Research Satellite (UARS), the Extreme Ultraviolet Explorer (EUVE), and the Solar Anomalous Magnetospheric Particle Explorer (SAMPEX). Both UARS and EUVE use the multimission modular spacecraft (MMS) concept. SAMPEX is part of the Small Explorer (SMEX) series and uses a much simpler set of attitude sensors. This paper centers on algorithm and design concepts for a multimission system and discusses flight experience from UARS
Solid state crystal physics at very low temperatures
The properties of nearly perfect crystals was studied at cryogenic temperatures. A large Helium 3 and Helium 4 dilution refrigerator has been assembled, and is described. A cryostat suitable for cooling a 35 liter volume to .020 Kelvin was designed and constructed, together with instrumentation to observe the properties of nearly perfect crystals
Properties of large nearly perfect crystals at very low temperatures
A liquid helium cryostat of a size and construction unavailable commercially, was built for use in measuring the Q of several materials at milli-Kelvin temperatures. The design and testing of the cryostat is described as well as the design of the experiment vacuum chamber and adaptor for the dilution refrigerator insert. Theory, design, and testing are also discussed for the magnetic coils built to levitate the materials so as to isolate them and increase the measured Q. A four point suspension with capacitor end plates as the transducer was used to obtain preliminary Q measurements of 6061 aluminum alloy and single crystal silicon. Results are tabulated
A case series and systematic review of rapid eye movement sleep behavior disorder outcome after deep brain stimulation in Parkinson’s disease
Comparison between control-based continuation and phase-locked loop methods for the identification of backbone curves and nonlinear frequency responses
Control-based continuation (CBC) and phase-locked loops (PLL) are two experimental testing methods that have demonstrated great potential for the non-parametric identification of key nonlinear dynamic features such as nonlinear frequency responses and backbone curves. Both CBC and PLL exploit stabilizing feedback control to steer the dynamics of the tested system towards the responses of interest and overcome important difficulties experienced when applying conventional testing methods such as sine sweeps to nonlinear systems. For instance, if properly designed, the feedback controller can prevent the system from exhibiting untimely transitions between coexisting responses or even losing stability due to bifurcations. This contribution aims to highlight the similarities that exist between CBC and PLL and present the first thorough comparison of their capabilities. Comparisons are supported by numerical simulations as well as experimental data collected on a conceptually simple nonlinear structure primarily composed of a thin curved beam. The beam is doubly clamped and exhibits nonlinear geometric effects for moderate excitation amplitudes
A novel penalty-based reduced order modelling method for dynamic analysis of joint structures
This work proposes a new reduced order modelling method to improve the computational efficiency for the dynamic simulation of a jointed structures with localized contact friction non-linearities. We reformulate the traditional equation of motion for a joint structure by linearising the non-linear system on the contact interface and augmenting the linearised system by introducing an internal non-linear penalty variable. The internal variable is used to compensate the possible non-linear effects from the contact interface. Three types of reduced basis are selected for the Galerkin projection, namely, the vibration modes (VMs) of the linearised system, static modes (SMs) and also the trial vector derivatives (TVDs) vectors. Using these reduced basis, it would allow the size of the internal variable to change correspondingly with the number of active non-linear DOFs. The size of the new reduced order model therefore can be automatically updated depending on the contact condition during the simulations. This would reduce significantly the model size when most of the contact nodes are in a stuck condition, which is actually often the case when a jointed structure vibrates. A case study using a 2D joint beam model is carried out to demonstrate the concept of the proposed method. The initial results from this case study is then compared to the state of the art reduced order modeling
Predicting anisotropic displacement parameters using molecular dynamics:density functional theory plus dispersion modelling of thermal motion in benzophenone
Comparative classical and ab initio Molecular Dynamics study of molten and glassy germanium dioxide
A Molecular Dynamics (MD) study of static and dynamic properties of molten
and glassy germanium dioxide is presented. The interactions between the atoms
are modelled by the classical pair potential proposed by Oeffner and Elliott
(OE) [Oeffner R D and Elliott S R 1998, Phys. Rev. B, 58, 14791]. We compare
our results to experiments and previous simulations. In addition, an ab initio
method, the so-called Car-Parrinello Molecular Dynamics (CPMD), is applied to
check the accuracy of the structural properties, as obtained by the classical
MD simulations with the OE potential. As in a similar study for SiO2, the
structure predicted by CPMD is only slightly softer than that resulting from
the classical MD. In contrast to earlier simulations, both the static structure
and dynamic properties are in very good agreement with pertinent experimental
data. MD simulations with the OE potential are also used to study the
relaxation dynamics. As previously found for SiO2, for high temperatures the
dynamics of molten GeO2 is compatible with a description in terms of mode
coupling theory.Comment: 27 pages, 16 figure
Endotoxaemia in Haemodialysis: A Novel Factor in Erythropoetin Resistance?
Background/Objectives
Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of mortality risk, and associated with inflammation and malnutrition. This study aims to explore the potential link between previously unrecognised endotoxaemia and EPO Resistance Index (ERI) in HD patients.
Methodology/Principal Findings
50 established HD patients were studied at a routine dialysis session. Data collection included weight, BMI, ultrafiltration volume, weekly EPO dose, and blood sampling pre and post HD. ERI was calculated as ratio of total weekly EPO dose to body weight (U/kg) to haemoglobin level (g/dL). Mean haemoglobin (Hb) was 11.3±1.3 g/dL with a median EPO dose of 10,000 [IQR 7,500–20,000] u/wk and ERI of 13.7 [IQR 6.9–23.3] ((U/Kg)/(g/dL)). Mean pre-HD serum ET levels were significantly elevated at 0.69±0.30 EU/ml. Natural logarithm (Ln) of ERI correlated to predialysis ET levels (r = 0.324, p = 0.03) with a trend towards association with hsCRP (r = 0.280, p = 0.07). Ln ERI correlated with ultrafiltration volume, a driver of circulatory stress (r = 0.295, p = 0.046), previously identified to be associated with increased intradialytic endotoxin translocation. Both serum ET and ultrafiltration volume corrected for body weight were independently associated with Ln ERI in multivariable analysis.
Conclusions
This study suggests that endotoxaemia is a significant factor in setting levels of EPO requirement. It raises the possibility that elevated EPO doses may in part merely be identifying patients subjected to significant circulatory stress and suffering the myriad of negative biological consequences arising from sustained systemic exposure to endotoxin
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