Interrater agreement on classification of photoparoxysmal electroencephalographic response

Our goal was to assess the interrater agreement (IRA) of photoparoxysmal response (PPR) using the classification proposed by a task force of the International League Against Epilepsy (ILAE), and a simplified classification system proposed by our group. In addition, we evaluated IRA of epileptiform discharges (EDs) and the diagnostic significance of the electroencephalographic (EEG) abnormalities. We used EEG recordings from the European Reference Network (EpiCARE) and Standardized Computer-based Organized Reporting of EEG (SCORE). Six raters independently scored EEG recordings from 30 patients. We calculated the agreement coefficient (AC) for each feature. IRA of PPR using the classification proposed by the ILAE task force was only fair (AC = 0.38). This improved to a moderate agreement by using the simplified classification (AC = 0.56; P = .004). IRA of EDs was almost perfect (AC = 0.98), and IRA of scoring the diagnostic significance was moderate (AC = 0.51). Our results suggest that the simplified classification of the PPR is suitable for implementation in clinical practice

Symplectic connections and Fedosov's quantization on supermanifolds

A (biased and incomplete) review of the status of the theory of symplectic connections on supermanifolds is presented. Also, some comments regarding Fedosov's technique of quantization are made.Comment: Submitted to J. of Phys. Conf. Se

Cerebrospinal fluid markers of neuronal and glial cell damage in patients with autoimmune neurologic syndromes with and without underlying malignancies

Autoimmune neurologic syndromes can be paraneoplastic (associated with malignancies and/or onconeural antibodies), or non-paraneoplastic. Their clinical presentation is often similar. As prognosis is related to malignancy treatment, better biomarkers are needed to identify patients with malignancy. We investigated cerebrospinal fluid (CSF) markers of neuronal (neurofilament light chain, NFL and total tau protein, T-tau) and glial (glial fibrillary acidic protein) damage. CSF-NFL and T-tau were increased in both paraneoplastic and non-paraneoplastic autoimmune syndromes. Patients with manifest malignancies were older, had less epilepsy, more focal central and peripheral neurological signs and symptoms, and worse long-term outcome, than those without malignancy. CSF-NFL-levels predicted long-term outcome but were not diagnostic for malignancy, after age adjustment

Radiation heating of VVER-4440 thermocouple

coupled eutronphoton Monte Carlo transport to determine radiation heating that serves as the input to heat transfer calculation resulting in temperature bias evaluation. Various nuclear reactions contribute to radiation heating in the active volume of the thermocouple steel. Monte Carlo transport calculation of radiation heating for average fuel assembly in one of latest Dukovany NPP cycles was performed with MCNP code. Heating power was compared to values published previously for Paks and Kola NPPs. Heat transfer calculations were performed with TEPLO code developed in ŠKODA JS. Radiation heating can be considered as negligible if the axial shift between thermocouple active part and thermocouple socket is below 15 mm.TE01020455/Centrum pokročilých jaderných technologií (CANUT)Thermocouple located near the coolant outlet of the fuel assembly head may indicate a temperature biased by radiation heating and subsequently affect accuracy of incore measurements. The analysis splits into two part