Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016

BACKGROUND: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. OBJECTIVE: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. DESIGN: Descriptive, using GeoSentinel records. SETTING: 63 travel and tropical medicine clinics in 30 countries. PATIENTS: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016. MEASUREMENTS: Frequencies of demographic, trip, and clinical characteristics and complications. RESULTS: Starting in May 2015, 93 cases of Zika virus disease were reported. Common symptoms included exanthema (88%), fever (76%), and arthralgia (72%). Fifty-nine percent of patients were exposed in South America; 71% were diagnosed in Europe. Case status was established most commonly by polymerase chain reaction (PCR) testing of blood and less often by PCR testing of other body fluids or serology and plaque-reduction neutralization testing. Two patients developed Guillain–Barre syndrome, and 3 of 4 pregnancies had adverse outcomes (microcephaly, major fetal neurologic abnormalities, and intrauterine fetal death). LIMITATION: Surveillance data collected by specialized clinics may not be representative of all ill returned travelers, and denominator data are unavailable. CONCLUSION: These surveillance data help characterize the clinical manifestations and adverse outcomes of Zika virus disease among travelers infected in the Americas and show a need for global standardization of diagnostic testing. The serious fetal complications observed in this study highlight the importance of travel advisories and prevention measures for pregnant women and their partners. Travelers are sentinels for global Zika virus circulation and may facilitate further transmission

Pre-Travel Preparation of US Travelers Going Abroad to Provide Humanitarian Service, Global TravEpiNet 2009–2011

We analyzed characteristics of humanitarian service workers (HSWs) seen pre-travel at Global TravEpiNet (GTEN) practices during 2009–2011. Of 23,264 travelers, 3,663 (16%) travelers were classified as HSWs. Among HSWs, 1,269 (35%) travelers were medical workers, 1,298 (35%) travelers were non-medical service workers, and 990 (27%) travelers were missionaries. Median age was 29 years, and 63% of travelers were female. Almost one-half (49%) traveled to 1 of 10 countries; the most frequent destinations were Haiti (14%), Honduras (8%), and Kenya (6%). Over 90% of travelers were vaccinated for or considered immune to hepatitis A, typhoid, and yellow fever. However, for hepatitis B, 292 (29%) of 990 missionaries, 228 (18%) of 1,298 non-medical service workers, and 76 (6%) of 1,269 medical workers were not vaccinated or considered immune. Of HSWs traveling to Haiti during 2010, 5% of travelers did not receive malaria chemoprophylaxis. Coordinated efforts from HSWs, HSW agencies, and clinicians could reduce vaccine coverage gaps and improve use of malaria chemoprophylaxis

Malaria after international travel: a GeoSentinel analysis, 2003-2016.

BACKGROUND: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. METHODS: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria. RESULTS: There were 5689 travellers included; 325 were children <18 years. More than half (53%) were visiting friends and relatives (VFRs). Most (83%) were exposed in sub-Saharan Africa. The median trip duration was 32 days (interquartile range 20-75); 53% did not have a pre-travel visit. More than half (62%) were hospitalized; children were hospitalized more frequently than adults (73 and 62%, respectively). Ninety-two per cent had a single Plasmodium species diagnosis, most frequently Plasmodium falciparum (4011; 76%). Travellers with P. falciparum were most frequently VFRs (60%). More than 40% of travellers with a trip duration ≤7 days had Plasmodium vivax. There were 444 (8%) travellers with severe malaria; 31 children had severe malaria. Twelve travellers died. CONCLUSION: Malaria remains a serious threat to international travellers. Efforts must focus on preventive strategies aimed on children and VFRs, and chemoprophylaxis access and preventive measure adherence should be emphasized

Differential diagnosis of illness in travelers arriving from sierra Leone, Liberia, or guinea: A cross-sectional study from the Geosentinel surveillance network

Background: The largest-ever outbreak of Ebola virus disease (EVD), ongoing in West Africa since late 2013, has led to export of cases to Europe and North America. Clinicians encountering ill travelers arriving from countries with widespread Ebola virus transmission must be aware of alternate diagnoses associated with fever and other nonspecific symptoms. Objective: To define the spectrum of illness observed in persons returning from areas of West Africa where EVD transmission has been widespread. Design: Descriptive, using GeoSentinel records. Setting: 57 travel or tropical medicine clinics in 25 countries. Patients: 805 ill returned travelers and new mmigrants from Sierra Leone, Liberia, or Guinea seen between September 2009 and August 2014. Measurements: Frequencies of demographic and travelrelated characteristics and illnesses reported. Results: The most common specific diagnosis among 770 nonimmigrant travelers was malaria (n = 310 [40.3%]), with Plasmodium falciparum or severe malaria in 267 (86%) and non–P. falciparum malaria in 43 (14%). Acute diarrhea was the second most common diagnosis among nonimmigrant travelers (n= 95 [12.3%]). Such common diagnoses as upper respiratory tract infection, urinary tract infection, and influenza-like illness occurred in only 26, 9, and 7 returning travelers, respectively. Few instances of typhoid fever (n = 8), acute HIV infection (n = 5), and dengue (n = 2) were encountered. Limitation: Surveillance data collected by specialist clinics may not be representative of all ill returned travelers. Conclusion: Although EVD may currently drive clinical evaluation of ill travelers arriving from Sierra Leone, Liberia, and Guinea, clinicians must be aware of other more common, potentially fatal diseases. Malaria remains a common diagnosis among travelers seen at GeoSentinel sites. Prompt exclusion of malaria and other life-threatening conditions is critical to limiting morbidity and mortality

Acute Muscular Sarcocystosis: An International Investigation Among Ill Travelers Returning From Tioman Island, Malaysia, 2011-2012

A large outbreak of acute muscular sarcocystosis (AMS) among international tourists who visited Tioman Island, Malaysia, is described. Clinicians evaluating travelers returning ill from Malaysia with myalgia, with or without fever, should consider AMS in their differential diagnosi

Defining Short- and Long-Term Travel

Medicine, Faculty ofPediatrics, Department ofNon UBCReviewedFacult

Les problèmes de santé de Tintin: plus de traumatismes que de pathologies du voyageur

International audienceBackground : Despite the highly hazardous life-style led by comic book characters such as Tintin, we are unaware of any previous systematic description of the challenges and health impairments faced by Tintin in the course of his adventures.Methods : We evaluated the spectrum of health impairments (HIs) that Tintin sustained in his 23 adventures as well as their causes, consequences, and relation to travel. We diagnosed Tintin's HIs according to descriptive terms in the text. We then classified HIs as traumatic and non-traumatic, and distinguished between intentional (those perpetrated by others) and unintentional events.Results : We found 236 events leading to 244 HIs, 13 kidnappings, six hospitalisations and two surgical procedures. There was a median of 8 HIs/adventure (range 1–30/adventure). The mean number of HIs per adventure was much greater before 1945 than subsequently (14.9 vs. 6.1; P = 0.002), which was also true of the number of kidnappings (11 vs. 2; P = 0.001). Of the 244 HIs, there were 191 cases of trauma (78.3%) and 53 non-traumatic problems (21.7%). The most common form of trauma was concussion (62%) whereas the most common forms of non-traumatic problems were sleep problems (15.1%), depression/anxiety (13%), and gas or chloroform poisoning (13%). Overall, we found 46 losses of consciousness (LoC), including 29 traumatic and 17 non-traumatic LoCs. Of the 236 events, there were 69 (29%) perpetrated by others against Tintin (including 55 homicide attempts), and 167 (71%) events that were not (including 69 events related to Tintin's actions).Conclusion : Tintin's almost superhuman qualities, a luxury afforded him by his fictional status, make him highly resistant to trauma. He is also not susceptible to the usual travel-related illnesses but is easily influenced by his friends and Snowy, his faithful hound.Intérêt : Malgré la vie hasardeuse menée par les héros de bandes dessinées comme Tintin, nous n’avons pas connaissance d’études ayant évalué les événements et les problèmes de santé présentés par Tintin pendant ses aventures.Méthodes : Nous avons évalué le spectre des problèmes de santé (PS) que Tintin a eu au cours de ses 23 aventures, ainsi que leurs causes, conséquences et lien avec le voyage. Les PS ont été diagnostiqués en fonction de leur description dans le texte puis classés en distinguant les problèmes traumatiques des problèmes non traumatiques. Les causes ont été classées en distinguant les événements intentionnels et non intentionnels.Résultats : Nous avons trouvé 236 événements conduisant à 244 PS, 13 kidnappings, six hospitalisations et deux actes chirurgicaux. Le nombre médian de PS est de 8/aventure (1–30/aventure). Le nombre moyen d’événements par aventure était significativement plus élevé avant 1945 (14.9 vs 6.1 ; p = 0,002), de même pour les kidnappings (11 vs 2 ; p = 0,001). Parmi les 244 PS, 191 étaient traumatiques (78.3 %) et 53 non traumatiques (21.7 %). Les plus fréquents des traumatismes étaient les traumatismes crâniens (62 %), et les plus fréquents des PS non traumatiques étaient les problèmes de sommeil (15.1 %), les manifestations anxieuses (13 %), et les intoxications au gaz ou au chloroforme (13 %). Nous avons trouvé 46 pertes de connaissance : 29 d’origine traumatique et 17 non traumatiques. Parmi les 236 événements, 69 (29 %) sont intentionnels, perpétrés par des tiers contre Tintin (dont 55 tentatives d’homicides), et 167 (71 %) non intentionnels (dont 69 sont la conséquence des actions de Tintin).Conclusion : Les qualités presque surhumaines de Tintin font de lui un personnage de fiction très résistant aux traumatismes. Tintin n’a pas de PS liés aux voyages. Mais il semble être très vulnérable aux problèmes affectant ses compagnons de voyage et notamment Milou, son fidèle compagnon