Saturation effect for dependence of the electrical conductivity of planar oriented nematic liquid crystal 6CB on the concentration of Cu7PS6 nanoparticles

The influence of Cu7PS6 nanoparticles with the average size 117 nm on the dielectric properties of planar oriented nematic liquid crystal 6CB has been investigated within the frequency range 10(1) ...10(6) Hz and at the temperature 293 K. It has been shown that when changing the concentration of nanoparticles within the range 0 to 1 wt.%, the conductivity of the liquid crystal changes stronger than its dielectric permittivity. It has been shown that the electrical conductivity increases monotonously with increasing the concentration of nanoparticles. However, for this dependence a saturation effect is observed. The mechanism of this effect was proposed.info:eu-repo/semantics/publishedVersio

ВЗАЄМОЗВ’ЯЗКИ ОСТЕОКАЛЬЦИНУ З ГОРМОНАЛЬНО-МЕТАБОЛІЧНИМИ ПОРУШЕННЯМИ ЧОЛОВІКІВ З ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ З РІЗНИМ СТУПЕНЕМ ОЖИРІННЯ (огляд літератури і власні дослідження)

The bone hormone osteocalcin is formed by osteoblasts and is partially released into the bloodstream during bone resorption, being a biomarker of bone remodeling. Osteocalcin also plays an important role in the endocrine regulation of metabolic and energy processes in the body and in their coordination. Osteocalcin uses a feedback mechanism to regulate insulin secretion, insulin sensitivity of peripheral tissues, and adipokine levels. In general, the secretion of osteocalcin and insulin are important factors in the formation of hormonal-metabolic phenotype, body composition, determination of regional distribution and metabolic activity of both bone and adipose tissue.The aim of this study was to establish the relationship between osteocalcin concentration and hormonal changes in men with type 2 diabetes with and without obesity on the background of involutive changes. Results. 64 men with type 2 diabetes, older than 50 years, were divided into 2 groups by BMI: 1) non-obese, BMI <30 kg / m2 (n = 31); 2) -obese, BMI ≥ 30 kg / m2 (n = 33). Lower levels of insulin secretion (lower serum C-peptide and insulin levels) were observed in non-obese patients in the absence of a compensatory increase in proinsulin levels. It can be assumed that the increase in the concentration of osteocalcin in group 1 is compensatory, although it does not have a significant effect on blood glucose levels. However, it may have a protective effect on the severity of insulin resistance syndrome and related metabolic disorders. Lower levels of osteocalcin in the obese group were associated with a higher degree of insulin resistance and insulin secretion. There was no significant difference between the two groups in serum proinsulin levels, as well as in androgen supply, which was assessed by the levels of total testosterone, testosteronestradiol-binding globulin, and free testosterone index. Conclusion. Lower levels of osteocalcin may be a marker of an increased risk of adverse metabolic changes in obese patients with type 2 diabetes, followed by complications compared to non-overweight patientsThe bone hormone osteocalcin is formed by osteoblasts and is partially released into the bloodstream during bone resorption, being a biomarker of bone remodeling. Osteocalcin also plays an important role in the endocrine regulation of metabolic and energy processes in the body and in their coordination. Osteocalcin uses a feedback mechanism to regulate insulin secretion, insulin sensitivity of peripheral tissues, and adipokine levels. In general, the secretion of osteocalcin and insulin are important factors in the formation of hormonal-metabolic phenotype, body composition, determination of regional distribution and metabolic activity of both bone and adipose tissue.The aim of this study was to establish the relationship between osteocalcin concentration and hormonal changes in men with type 2 diabetes with and without obesity on the background of involutive changes. Results. 64 men with type 2 diabetes, older than 50 years, were divided into 2 groups by BMI: 1) non-obese, BMI <30 kg / m2 (n = 31); 2) -obese, BMI ≥ 30 kg / m2 (n = 33). Lower levels of insulin secretion (lower serum C-peptide and insulin levels) were observed in non-obese patients in the absence of a compensatory increase in proinsulin levels. It can be assumed that the increase in the concentration of osteocalcin in group 1 is compensatory, although it does not have a significant effect on blood glucose levels. However, it may have a protective effect on the severity of insulin resistance syndrome and related metabolic disorders. Lower levels of osteocalcin in the obese group were associated with a higher degree of insulin resistance and insulin secretion. There was no significant difference between the two groups in serum proinsulin levels, as well as in androgen supply, which was assessed by the levels of total testosterone, testosteronestradiol-binding globulin, and free testosterone index. Conclusion. Lower levels of osteocalcin may be a marker of an increased risk of adverse metabolic changes in obese patients with type 2 diabetes, followed by complications compared to non-overweight patient

РОЛЬ ОСТЕОКАЛЬЦИНУ В РЕГУЛЯЦІЇ СЕКРЕЦІЇ ІНСУЛІНУ ТА ОСТЕОТРОПНИХ ЕФЕКТІВ РІЗНИХ КЛАСІВ ПРОТИДІАБЕТИЧНИХ ПРЕПАРАТІВ (огляд літератури і власні дослідження)

Background. Current data suggest that bone tissue produces hormonally active factors - modulators of metabolic processes throughout the body. The most significant osteoproteins is osteocalcin, the non-collagen structural protein of the bone matrix, which is synthesized by osteoblasts and enters the bloodstream during the resorption of bone tissue. Osteocalcin is involved in the regulation of energy balance, insulin secretion, peripheric insulin sensitivity, and adipocyte’s function, while being an important marker of bone remodeling. The aim of this study was to investigate the relationship between osteocalcin levels and metabolic parameters in 97 patients with type 2 diabetes over 50 years of age, in the course of pharmacotherapy using different classes of antidiabetic drugs, namely human insulin, glucagon-like peptide-1 agonists (aGLP), and sodium-glucose co-transporter 2 (SGLT2) inhibitors, depending on presence of obesity. Results. There was found the highest serum osteocalcin level in patients without obese who received a metabolically active therapy with insulin or aGLP-1, comparing to nonobese subjects of SGLT2 inhibitors therapy group. The lowest level of HbA1c and triglycerides observed in non-obese patients on the background of taking aGLP-1. Conclusion. It can be assumed that the factor determining the hypoglycemic efficacy of investigated drugs may be the pathogenesis of type 2 diabetes which depends on the degree of obesity, while the type of antidiabetic therapy has a corrective effect, probably mediated by changes in body weight and fat distribution.Background. Current data suggest that bone tissue produces hormonally active factors - modulators of metabolic processes throughout the body. The most significant osteoproteins is osteocalcin, the non-collagen structural protein of the bone matrix, which is synthesized by osteoblasts and enters the bloodstream during the resorption of bone tissue. Osteocalcin is involved in the regulation of energy balance, insulin secretion, peripheric insulin sensitivity, and adipocyte’s function, while being an important marker of bone remodeling. The aim of this study was to investigate the relationship between osteocalcin levels and metabolic parameters in 97 patients with type 2 diabetes over 50 years of age, in the course of pharmacotherapy using different classes of antidiabetic drugs, namely human insulin, glucagon-like peptide-1 agonists (aGLP), and sodium-glucose co-transporter 2 (SGLT2) inhibitors, depending on presence of obesity. Results. There was found the highest serum osteocalcin level in patients without obese who received a metabolically active therapy with insulin or aGLP-1, comparing to nonobese subjects of SGLT2 inhibitors therapy group. The lowest level of HbA1c and triglycerides observed in non-obese patients on the background of taking aGLP-1. Conclusion. It can be assumed that the factor determining the hypoglycemic efficacy of investigated drugs may be the pathogenesis of type 2 diabetes which depends on the degree of obesity, while the type of antidiabetic therapy has a corrective effect, probably mediated by changes in body weight and fat distribution

Остатки рыб из раскопок кургана эпохи бронзы около с. Марьянское (Днепропетровская область, Украина)

The Bronze Age mound (2.5–2.3 kya BC) is located near the Maryanskoe village (Apostolovskyi district, Dnepropetrovsk region) and was excavated in 1953. The results of determination of the fish remnants, which were found during the excavation, are presented in the paper. Eleven species belonging to 9 genera, 5 families and 5 orders (Acipenseriformes, Cypriniformes, Siluriformes, Esociformes, Perciformes) were identified: russian sturgeon Acipenser gueldenstaedtii Brandt et Ratzeburg, 1833, stellate sturgeon A. stellatus Pallas, 1771, common ide Idus idus (Linnaeus, 1758), common roach Rutilus rutilus (Linnaeus, 1758), pontic roach R. frisii (Nordmann, 1840), common bream Abramis brama (Linnaeus, 1758), common carp Cyprinus carpio Linnaeus, 1758, tench Tinca tinca (Linnaeus, 1758), european catfish Silurus glanis Linnaeus, 1758, northern pike Esox lucius (Linnaeus, 1758), and zander Sander lucioperca (Linnaeus, 1758). Most of them are quite common in the Dnieper river basin. It was found that carp fishes predominate in the number of species. Most of the bone remnants in the collection belong to zander, catfish and pike, while common roach, pontic roach and common bream are identified by the few bones. This may indicate a different role of these species in the diet of the local population. The ratio of skeletal elements in the collection is the evidence of the fish cutting on the site. Body length and weight was reconstructed for 64 fish specimens. It was found that they were mature and small-sized, except for catfish, pike and perch. Taking into account the characteristics of the funeral rituals of the Yamna culture population, fish bones from the mound near Maryanskoe can be remnants of the parting meal.Представлены результаты определения остатков рыб, обнаруженных в сосуде при раскопках одного из позднеямных погребений в кургане эпохи бронзы, расположенном в окрестностях с. Марьянское Апостоловского района Днепропетровской области. Установлено наличие 11 видов, относящихся к 9 родам 5 семейств 5 отрядов (Acipenseriformes, Cypriniformes, Siluriformes, Esociformes, Perciformes). Установлено, что карповые рыбы преобладают по количеству видов. Большинство костных остатков в сборах принадлежит судаку, сому и щуке, в то время как плотва, вырезуб и лещ идентифицированы по немногочисленным костям. Это может свидетельствовать о различной роли этих видов в рационе местного населения. Соотношение элементов скелета в сборах свидетельствует о разделке рыбы непосредственно на месте. Для 64 особей рыб по целым костям реконструированы длина тела и масса. Установлено, что все они были половозрелыми и, за исключением сома, щуки и судака, имели небольшие размеры. Учитывая особенности погребальной обрядности населения ямной культуры, кости рыб из курганного погребения около с. Марьянское можно рассматривать в качестве остатков напутственной еды

МОДЕЛЮВАННЯ ОПТИМАЛЬНОЇ СТРУКТУРИ АКТИВІВ ПІДПРИЄМСТВ М’ЯСОПЕРЕРОБНОЇ ПРОМИСЛОВОСТІ

In today’s economic conditions, problems of functioning of domestic enterprises are not limited by lack of sources of financing of assets, but also often associated with inefficient investment in specific components of property, which adversely affects the level of economic efficiency of Ukrainian enterprises and the development of the economy as a whole. An important factor in making sound, rational and sound decisions about asset management is to improve existing or develop fundamentally new methods and models for optimizing the structure of assets of Ukrainian enterprises using criteria that are most relevant to current economic requirements, environmental challenges and internal objectives. In view of the above, the article demonstrates a clear dependence of the structure of the assets of the enterprise and the key indicators that characterize the effectiveness of its management. The optimal structure of assets for the studied enterprises and possible ways of their achievement are offered taking into account the defined criteria. A comparative assessment of the assets structure of the surveyed enterprises before and after optimization was carried out and on this basis the latter was confirmed by comparing the key parameters of the enterprise performance — profit and market value. A clear sequence of stages of the asset structure optimization model is proposed and described, along with methodological aspects of determining the effective structure of assets, the feasibility of its practical application at Ukrainian enterprises is proved through the achievement of the key goal of the enterprise activity — maximization of market value and profit.У сучасних умовах господарювання проблеми функціонування вітчизняних підприємств не обмежуються браком джерел фінансування активів, але часто пов’язані з неефективним вкладенням коштів у конкретні складові майна, що негативно позначається на рівні ефективності господарювання підприємств України та розвитку економіки в цілому. Вагомим чинником ухвалення зважених, раціональних та обґрунтованих рішень щодо управління активами є удосконалення наявних або розроблення принципово нових методів і моделей оптимізації структури активів підприємств України з використанням критеріїв, які найбільше відповідають сучасним економічним вимогам, викликам зовнішнього середовища та внутрішнім цільовим орієнтирам діяльності підприємства. Зважаючи на вищезазначене, продемонстровано чітку залежність структури активів підприємства і ключових показників, що характеризують ефективність його господарювання. Запропоновано оптимальну з урахуванням визначених критеріїв структуру активів для досліджуваних підприємств та можливі способи їх досягнення. Проведено порівняльну оцінку структури активів досліджуваних підприємств до і після оптимізації та на цій основі підтверджено ефективність останньої шляхом порівняння ключових параметрів ефективності діяльності підприємства — прибутку та ринкової вартості. Запропоновано та описано послідовність етапів моделі оптимізації структури активів із зазначенням методичних аспектів визначення оптимальної структури активів, доведено доцільність її практичного застосування на підприємствах України через досягнення ключової цілі діяльності підприємства — збільшення ринкової вартості та прибутку

ОБ ГРУНТУВАННЯ ВИБОРУ МЕТОДУ ХІРУРГІЧНОГО ЛІКУВАННЯ ХВОРИХ НА ГОСТРИЙ ХОЛЕЦИСТИТ

The article is devoted to the problems of surgical treatment of 147 patients with acute cholecystitis. 117 patients were operated laparoscopically and 30 patient had the open cholecystectomy. The priority of the invasive surgical approach for patients with acute cholecystitis was proved.У статті висвітлено проблему хірургічного лікування 147 хворих на гострий холецистит. У 117 із них проведено лапароскопічні операції, а в 30 — відкриту холецистектомію. Доведено перевагу активної хірургічної тактики та лапароскопічної холецистектомії у хворих на гострий холецистит

ОСОБЛИВОСТІ ХІРУРГІЧНОЇ ТАКТИКИ ЛІКУВАННЯ КРОВОТОЧИВОЇ ВИРАЗКИ ШЛУНКА

Authors made the analysis of results of research and surgical treatment of 105 patients with a stomach ulcer of a stomach complicated with bleeding. Complex research of central haemodynamic indices, coagulation systems and hemoreological properties of blood, and also the data of endoscopy and clinical research enabled to estimate objectively a degree of weight of a condition of the patient and in due time to prove expediency of surgical intervention in each concrete case of disease.Проаналізовано результати дослідження і хірургічного лікування 105 хворих на виразкову хворобу шлунка, ускладнену кровотечею. Комплексне дослідження показників центральної гемодинамі- ки, згортальної системи і гемореологічних властивостей крові, а також дані ендоскопічного та клінічного дослідження дали можливість об'єктивно оцінити ступінь тяжкості стану хворого з кровоточивою виразкою шлунка та своєчасно обгрунтувати доцільність хірургічного втручання в кожному конкретному випадку захворювання

Determination of Safety Indicators in the Developed Muffins with Non-traditional Raw Materials

The aim of research is studying the effect of unconventional raw materials (buckwheat, oatmeal, rye, corn, milk whey, skimmed milk powder, propolis, flower pollen, bean powder, sesame oil, pumpkin seed oil, walnut oil, walnut kernels, candied fruit mixes (apple-cherry fruits of bilberries, natural honey with floral pollen, natural honey with propolis) for the quality and safety of new muffins. The article analyzes the results of the study of the quality and safety indicators of muffins of improved composition, manufactured using non-traditional raw materials. For the preparation of new types of muffins, part of the wheat flour was replaced with buckwheat, corn, oat, milk whey, skimmed milk powder and additives of vegetable origin. Margarine has been replaced by vegetable oils. It has been established that flour confectionery products have high organoleptic properties. From the physico-chemical parameters, the mass fraction of total sugar was determined, which ranged from 28.17 % to 33.07 %, the mass fraction of fat – 16.2–20.66 %, the mass fraction of moisture – 18.0–22.0, mass fraction of ash – 0.03–1.3 %, alkalinity – 0.03–1.8°, the content of toxic elements (copper, zinc, lead, cadmium, arsenic, mercury) and microbiological indicators were also determined. Based on the data obtained as a research result, the expediency of using non-traditional raw materials to expand the range of flour confectionery products, in particular muffins is substantiated

Building a technology for mass organisation of distance learning for students in quarantine based on the Moodle platform

The COVID-19 pandemic has necessitated the rapid transition to distance learning for students worldwide. This paper examines the current state of distance learning implementation in secondary schools of the Zhytomyr region in Ukraine. A survey of 2445 teachers found that most were using various software tools for distance learning without a unified learning management system. Analysis of the Moodle, Google Classroom, and "My Class" platforms showed Moodle to have significant advantages for supporting distance learning. To enable schools to leverage Moodle, an "Educational Portal for Secondary School" was developed at Zhytomyr Polytechnic State University using the Moodle platform. Based on this Moodle portal, the paper proposes a technology for the mass organisation of distance learning during quarantine. The technology combines the tools, electronic resources, course structure, and tutor competencies required for effective distance learning implementation