743 research outputs found
Electronic Social Networks as Supporting Means of Educational Process in Higher Education Institutions
Given research describes experience of electronic social networks use in educational practices. It was determined that electronic social networks can be a powerful tool for support of educational process in higher education institutions, namely to support study of different disciplines. There are main advantages of electronic social networks use for education: universal accessibility and free of charge; possibility of instant messaging and multimedia data; user-friendly intuitive interface; ability to search data and information; availability of event scheduling, invitations, reminder settings; support for synchronous and asynchronous communication between network members; access from different devices. It is emphasized that one of the main advantages of electronic social networks is receipt of quick feedback and convenience of their tools and services. Nowadays, it is important to include network educational interaction in existing models of study organization. It is advisable to use electronic social networks to manage educational process in higher education institution. Efficiency of electronic social networks use depends on intensity and need for their use in educational system management for implementation of organizational, educational, psychological and pedagogical
functions and ensuring universal communication with subjects of educational process. Expediency of electronic social networks use to carry out research work at university is described. Electronic social networks are convenient tool to conduct surveys and questionnaires, to create thematic groups for specific issue discussion. Also it is possible to interact with researchers from different countries, share experiences and disseminate research findings, invite those who wish to participate in various scientific activities using these networks
Influence of tricalcium silicate on course of traumatic pulpitis
The use of Tricalcium Silicate (TS) as an odontotropic preparation makes it possible to create a hermetic crown restoration with a high degree of adhesion. However, the use of TS silicate by direct pulp capping remains disputable. The aim of this study was to determine the effects of TS on course of traumatic pulpitis by detection of morpho-functional peculiarities of changes in pulp tissue. We performed experimental investigation (on rabbits, males, aging three-month) for study of the morphofunctional changes of the pulp tissues with modeling of traumatic pulpitis and direct pulp capping with TS preparation (8 animals, investigated group) and calcium hydroxide (Calasept, NORDISKA DENTAL) preparation (8 animals, comparison group). After 2nd and 6th weeks tissues of tooth were fixed in 10% formalin with performing routine proceeding after decalcification and making histological slides which were investigated. Manifestations of protective adaptive mechanisms have been revealed in the form of inflammatory process two weeks after the injury in the pulp tissue with its resolution six weeks after performing of direct pulp capping with TS with replacement of necrotic area by connective tissue with their delimitation from viable pulp tissue against a background of intensive formation of capillaries. Morphometric study proved dynamical changes of vascular number cross-sections per 1 mm2 from 69.31Β±4.76 (2 weeks) to 47.38Β±4.12 (6 weeks) with 49.2Β±3.47 vascular density in intact group. Cellular density of odontoblasts as changed from 3.92Β±1.03 x103 per 1 mm2 (2 weeks) to 7.49Β±1.51 x103 per 1 mm2 (6 weeks) with 8.3Β±1.02 x103 per 1 mm2 cellular density in intact group. Thus it can be argued that the use of TS as a material for direct pulp capping promotes more active regeneration processes.
Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΠΈΠΊΠ°Π»ΡΡΠΈΠΉΡΠΈΠ»ΠΈΠΊΠ°ΡΠ° Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ»ΡΠΏΠΈΡΠ°. ΠΠΎΡΡΠ°Π²Π»Π΅Π½ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½Ρ Π½Π° 3-ΠΌΠ΅ΡΡΡΠ½ΡΡ
ΠΊΡΠΎΠ»ΠΈΠΊΠ°Ρ
ΡΠ°ΠΌΡΠ°Ρ
Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΡΡΠΎΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΡΠ»ΡΠΏΡ Ρ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ»ΡΠΏΠΈΡΠ° ΠΈ ΠΏΡΡΠΌΡΠΌ ΠΏΠΎΠΊΡΡΡΠΈΠ΅ΠΌ ΠΏΡΠ»ΡΠΏΡ ΡΡΠΈΠΊΠ°Π»ΡΡΠΈΠΉΡΠΈΠ»ΠΈΠΊΠ°ΡΠΎΠΌ (8 ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠ°Ρ Π³ΡΡΠΏΠΏΠ°) ΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ΄ΠΎΠΌ ΠΊΠ°Π»ΡΡΠΈΡ (Calasept, NORDISKA DENTAL) (8 ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, Π³ΡΡΠΏΠΏΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ). Π‘ΠΏΡΡΡΡ 2 ΠΈ 6 Π½Π΅Π΄Π΅Π»ΠΈ ΡΠΊΠ°Π½ΠΈ Π·ΡΠ±Π° ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π»ΠΈ Π² 10% ΡΠΎΡΠΌΠ°Π»ΠΈΠ½Π΅ ΠΈ ΠΏΠΎΡΠ»Π΅ Π΄Π΅ΠΊΠ°Π»ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΡΡΡΠΈΠ½Π½ΠΎΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΊΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ. Π‘ΠΏΡΡΡΡ 2 Π½Π΅Π΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ Π½Π°Π½Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠ°Π²ΠΌΡ Π² ΡΠΊΠ°Π½ΠΈ ΠΏΡΠ»ΡΠΏΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π·Π°ΡΠΈΡΠ½ΠΎ-ΠΏΡΠΈΡΠΏΠΎΡΠΎΠ±ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π² Π²ΠΈΠ΄Π΅ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Ρ Π΅Π³ΠΎ ΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π·ΠΎΠ½Ρ Π½Π΅ΠΊΡΠΎΠ·Π° ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΠΏΠΈΠ»Π»ΡΡΠΎΠ², ΡΡΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΠΈΡΠΊΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ»Π°. ΠΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
ΡΠ΅ΡΠ΅Π½ΠΈΠΉ Ρ 69,31Β±4,76/ΠΌΠΌ2 (2 Π½Π΅Π΄Π΅Π»ΠΈ) Π΄ΠΎ 47,38Β±4,12/ΠΌΠΌ2 (6 Π½Π΅Π΄Π΅Π»Ρ) ΠΏΡΠΈ 49,2Β±3,47/ΠΌΠΌ2 Π² ΠΈΠ½ΡΠ°ΠΊΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅. ΠΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΎΠ΄ΠΎΠ½ΡΠΎΠ±Π»Π°ΡΡΠΎΠ² ΠΈΠ·ΠΌΠ΅Π½ΠΈΠ»Π°ΡΡ
Ρ 3,92Β±1,03Γ103/ΠΌΠΌ2 (2 Π½Π΅Π΄Π΅Π»ΠΈ) Π΄ΠΎ 7,49Β±1,51Γ103/ΠΌΠΌ2 (6 Π½Π΅Π΄Π΅Π»Ρ) ΠΏΡΠΈ 8,3Β±1,02Γ103/ΠΌΠΌ2 ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ Π² ΠΈΠ½ΡΠ°ΠΊΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΈΠΊΠ°Π»ΡΡΠΈΠΉΡΠΈΠ»ΠΈΠΊΠ°ΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π΄Π»Ρ ΠΏΡΡΠΌΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΡΡΠΈΡ ΠΏΡΠ»ΡΠΏΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ
NO EXCESSIVE CRUSTAL GROWTH IN THE CENTRAL ASIAN OROGENIC BELT: FURTHER EVIDENCE FROM FIELD RELATIONSHIPS AND ISOTOPIC DATA
We provide new field observations and isotopic data for key areas of the Central Asian Orogenic Belt (CAOB), reiterating that no excessive crustal growth occurred during its ca. 800 Ma long orogenic evolution. Many Precambrian blocks (microcontinents) identified in the belt are exotic and are most likely derived from the northern margin of Gondwana, including the Tarim craton.We provide new field observations and isotopic data for key areas of the Central Asian Orogenic Belt (CAOB), reiterating that no excessive crustal growth occurred during its ca. 800 Ma long orogenic evolution. Many Precambrian blocks (microcontinents) identified in the belt are exotic and are most likely derived from the northern margin of Gondwana, including the Tarim craton
Dynamics of findings of non-specific resistance in the mouth cavity in children with lesions of the mucous membrane epithelium of the mouth cavity against acute lymphoblastic leukemia in the treatment process.
There was conΒducted study of dynamics of findings of non-specific resistance in the mouth cavity in children with lesions of the mucous membrane epithelium of the mouth cavity against acute lymphoblastic leukemiaΒ in the treatment process by authors-developed methods. It is known that in children with leukemia immunodeficiency states develop immunological disorders resulted from treatment with cytotoxic drugs. Moreover, not only general, but also the local immunity of the mouth cavity suffers, which is accompanied by development of infectious processes in the tissues that perform the barrier function, which include mucous membrane epithelium of the mouth cavity. A key role in the system of antimicrobial protection of the mouth cavity is performed by mucolytic enzyme lisocyme and Ξ±-defensins (HNP 1-3). 76 children with acute lymphoblastic leukemiaΒ aged from 2 to 18 years sufferingΒ from such dental diseases as generalized chronic catarrhal gingivitis, erosive-ulcerative and candidal stomatitis took part in the clinical study. All children under clinical study were divided into 2 groups - the main and comparison. Standard protocol treatment was used in the comparison group. Developed treatment-and-prophylactic complex was used in the main group. The children of the main group were prescribed developed treatment-and-prophylactic complex depending on the period of the disease: the first version of local treatment was used in the acute period and the relapse of the disease, the second - in the period of remission. The results of research have shown a stimulating effect of therapeutic and prophylactic measures on the natural antimicrobial system of mouth cavity protection, both in children of the main groups under study and in the comparison groups. Such a phenomenon should be considered as a positive process that contributes to the increase of resistance in periodontal tissues and mucous membrane epithelium of the mouth cavity
EARLY NEOPROTEROZOIC CRUST FORMATON IN THE DZABKHAN MICROCONTINENT, CENTRAL ASIAN OROGENIC BELT
The Dzabkhan microcontinent was defined by [Mossakovsky et al., 1994] as a cratonic terrane with an early Precambrian basement that combines highgrade metamorphic complexes of the Songino, Dzabkhan, Otgon, Baidarik, Ider and Jargalant Blocks. However, early Precambrian ages have so far only been recognized in the Baidarik and Ider blocks [Kozakov et al., 2007, 2011; KrΓΆner et al., 2015].The Dzabkhan microcontinent was defined by [Mossakovsky et al., 1994] as a cratonic terrane with an early Precambrian basement that combines highgrade metamorphic complexes of the Songino, Dzabkhan, Otgon, Baidarik, Ider and Jargalant Blocks. However, early Precambrian ages have so far only been recognized in the Baidarik and Ider blocks [Kozakov et al., 2007, 2011; KrΓΆner et al., 2015]
A multiscale analysis of gene flow for the New England cottontail, an imperiled habitat specialist in a fragmented landscape
Landscape features of anthropogenic or natural origin can influence organisms\u27 dispersal patterns and the connectivity of populations. Understanding these relationships is of broad interest in ecology and evolutionary biology and provides key insights for habitat conservation planning at the landscape scale. This knowledge is germane to restoration efforts for the New England cottontail (Sylvilagus transitionalis), an early successional habitat specialist of conservation concern. We evaluated local population structure and measures of genetic diversity of a geographically isolated population of cottontails in the northeastern United States. We also conducted a multiscale landscape genetic analysis, in which we assessed genetic discontinuities relative to the landscape and developed several resistance models to test hypotheses about landscape features that promote or inhibit cottontail dispersal within and across the local populations. Bayesian clustering identified four genetically distinct populations, with very little migration among them, and additional substructure within one of those populations. These populations had private alleles, low genetic diversity, critically low effective population sizes (3.2-36.7), and evidence of recent genetic bottlenecks. Major highways and a river were found to limit cottontail dispersal and to separate populations. The habitat along roadsides, railroad beds, and utility corridors, on the other hand, was found to facilitate cottontail movement among patches. The relative importance of dispersal barriers and facilitators on gene flow varied among populations in relation to landscape composition, demonstrating the complexity and context dependency of factors influencing gene flow and highlighting the importance of replication and scale in landscape genetic studies. Our findings provide information for the design of restoration landscapes for the New England cottontail and also highlight the dual influence of roads, as both barriers and facilitators of dispersal for an early successional habitat specialist in a fragmented landscape
Common Fronto-temporal Effective Connectivity in Humans and Monkeys
Cognitive pathways supporting human language and declarative memory are thought to have uniquely evolutionarily differentiated in our species. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed a new approach using functional imaging to visualize the impact of direct electrical brain stimulation in human neurosurgery patients. Applying the same approach with macaque monkeys, we found remarkably comparable patterns of effective connectivity between auditory cortex and ventro-lateral prefrontal cortex (vlPFC) and parahippocampal cortex in both species. Moreover, in humans electrical tractography revealed rapid evoked potentials in vlPFC from stimulating auditory cortex and speech sounds drove vlPFC, consistent with prior evidence in monkeys of direct projections from auditory cortex to vocalization responsive regions in vlPFC. The results identify a common effective connectivity signature that from auditory cortex is equally direct to vlPFC and indirect to the hippocampus (via parahippocampal cortex) in human and nonhuman primates
Common Fronto-temporal Effective Connectivity in Humans and Monkeys
Human brain pathways supporting language and declarative memory are thought to have differentiated substantially during evolution. However, cross-species comparisons are missing on site-specific effective connectivity between regions important for cognition. We harnessed functional imaging to visualize the effects of direct electrical brain stimulation in macaque monkeys and human neurosurgery patients. We discovered comparable effective connectivity between caudal auditory cortex and both ventro-lateral prefrontal cortex (VLPFC, including area 44) and parahippocampal cortex in both species. Human-specific differences were clearest in the form of stronger hemispheric lateralization effects. In humans, electrical tractography revealed remarkably rapid evoked potentials in VLPFC following auditory cortex stimulation and speech sounds drove VLPFC, consistent with prior evidence in monkeys of direct auditory cortex projections to homologous vocalization-responsive regions. The results identify a common effective connectivity signature in human and nonhuman primates, which from auditory cortex appears equally direct to VLPFC and indirect to the hippocampus
A Novel Autosomal Dominant Inclusion Body Myopathy Linked to 7q22.1-31.1
We describe a novel autosomal dominant hereditary inclusion body myopathy (HIBM) that clinically mimics limb girdle muscular dystrophy in a Chinese family. We performed a detailed clinical assessment of 36 individuals spanning four generations. The age of onset ranged from the 30s to the 50s. Hip girdle, neck flexion and axial muscle weakness were involved at an early stage. This disease progressed slowly, and a shoulder girdle weakness appeared later in the disease course. Muscle biopsies showed necrotic, regenerating, and rimmed vacuolated fibers as well as congophilic inclusions in some of the fibers. Electron micrograph revealed cytoplasmic inclusions of 15β21 nm filaments. A genomewide scan and haplotype analyses were performed using an Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM), which traced the disease to a new locus on chromosome 7q22.1β31.1 with a maximum multi-point LOD score of 3.65. The critical locus for this unique disorder, which is currently referred to as hereditary inclusion body myopathy 4 (HIBM4), spans 8.78 Mb and contains 65 genes. This localization raises the possibility that one of the genes clustered within this region may be involved in this disorder
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