A walk in the PARC:developing and implementing 21st century chemical risk assessment in Europe

Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety

Mixed ligand Ru(II) complexes with 2,2′-bipyridine and 2-(2′-pyridyl)quinoxaline

The synthesis and the physical properties of a new series of Ru(II) mixed ligand tris chelate complexes of the type [LxRu (bpy)3-x], where L = 2-(2′-pyridyl) quinoxaline and bpy = 2,2′-bipyridine, are reported. The complexes were fully characterized by NMR spectroscopic techniques, Electrospray Mass Spectroscopy, UV-visible spectra and elemental analyses. The complex [RuL3](PF6)2 probably has the mer conformation due to the bulky shape of the L on the side of quinoxaline. The complex [RuL2(bpy)](PF6)2 was isolated as a mixture of all three possible geometric isomers, while the [RuL(bpy)2](PF6)2 in only one isomer as theoretically expected. Photoinduced dissociation of one molecule of the ligand L from the complex [RuL3](PF6)2 upon exposure to room light has been studied by 1H NMR and UV-vis Spectroscopies. © 1999 Elsevier Science Ltd. All rights reserved

"SCCS ADDENDUM to the scientific opinion on Zinc pyrithione (P81)" ref. SCCS/1512/13 - SCCS/1593/2018 Final Opinion

The SCCS adopted this document at its plenary meeting on 21-22 February 2018 – 18 pageshttps://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_216.pd

"Opinion on the safety of cosmetic ingredient Phenylene Bis-Diphenyltriazine (CAS No 55514-22-2) -S86 - Submission II" - SCCS/1594/18 - Final Version

International audienceThe SCCS adopted the final Opinion by written procedure on 30 July 2018 (64 pages) - https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_215.pd

Opinion of the Scientific Committee on consumer safety (SCCS) – Final opinion on the safety of fragrance ingredient Acetylated Vetiver Oil (AVO) - (Vetiveria zizanioides root extract acetylated) - Submission III

International audienc

OPINION ON Dihydroxyacetone (DHA) - CAS No. 96-26-4

International audienceOpinion on Dihydroxyacetone (DHA) CAS N° 96-26-4In light of the data provided, does the SCCS consider Dihydroxyacetone safe when used as hair colouring ingredient in leave-on applications up to a maximum concentration of 6.25 %? On the basis of data provided, the SCCS considers Dihydroxyacetone safe when used as hair colouring ingredient in leave-on applications (non-oxidative) up to a maximum concentration of 6.25%. Does the SCCS have any further scientific concerns with regard to the use of Dihydroxyacetone in cosmetic products? The use of Dihydroxyacetone as hair colouring ingredient in leave-on applications (nonoxidative) up to a maximum concentration of 6.25% together with the use of self-tanning lotion and face cream containing up to a maximum concentration of 10% Dihydroxyacetone is considered safe

"SCCS OPINION ON Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) - Submission II"SCCS/1605/19 - Preliminary Opinion

"SCCS OPINION ON Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) - Submission II"SCCS/1605/19 - Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, A. Koutsodimou, A. Simonnard, W. UterThe SCCS adopted this preliminary opinion at its plenary meeting on 26 February 2019 (52 pages)https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_227.pdf"SCCS OPINION ON Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) - Submission II"SCCS/1605/19 - Preliminary OpinionU. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, A. Koutsodimou, A. Simonnard, W. UterThe SCCS adopted this preliminary opinion at its plenary meeting on 26 February 2019 (52 pages)https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_227.pd

"SCCS OPINION on the safety of cosmetic ingredients Phenylene Bis-Diphenyltriazine (CAS No 55514-22-2)- S86 - Submission II"- SCCS/1594/18 Preliminary Opinion

The SCCS adopted this document at its plenary meeting on 21-22 February 2018 – 63 pageshttps://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_215.pd