1,027 research outputs found
Fermentation of Pineapple Taste Juice for the Production of Citric Acid Using Candida Lipolytica ATCC 8661
- Author
- Publication venue
- Publication date
- 01/01/1990
- Field of study
Fermentation of pineapple waste juice.using Candida lipolytica ATCC 8661 for production of citric acid was
conducted. A comparison study was also carried out using the
pineapple flesh juice (edible portion). Maximum production of
citric acid obtained from the flesh juice and waste juice was
2.5 g/l and 3.2 g/l respectively after 4 Days under submerged
fermentation using shake flasks at 30°C .The addition of 0.1% potassium dihydrogen phosphate in the
10Z pure glucose media increased the production of total acids
(citric acid). Addition of 3% methanol prior to incubation
into the pineapple waste juice showed a remarkable increase in citric acid production. Fermentation of pineapple waste juice
using Candida lipolytica ATCC 8661 was also conducted in LH
fermentor (Model 500). The effect of different levels of
dissolved oxygen saturation (10%, 20%, 30% and 40%) with and
without 3% methanol on citric acid production of pineapple
waste juice was studied over a 10-day fermentation period at
30C. The maximum citric acid production was 8.2 g/l in sample
with 3% methanol having 40% dissolved oxygen saturation after 8
days of fermentation. Maximum of biomass production of 12. 37
mg/ml juice (dry cell weight) was obtained from fermented
pineapple waste juice inoculated with C. lipolytica ATCC 8661
having 30% dissolved oxygen saturation after 8-10 days of
fermentation
High In-Vitro Antitumour Activity of Triphenyltin Coumarin 3-Carboxylate and its Coordination Complexes With Monodentate Oxygen Donor Ligands Against the Epstein Barr Virus (EBV)-DNA Positive Raji and the P-388 Murine Leukaemia Cell Lines, and Evidence for the Suppression by Organotin of the Early Antigen Complex in the EBV Lytic Cycle
- Publication venue
- Hindawi Publishing Corporation
- Publication date
- 01/01/2000
- Field of study
Triphenyltin coumarin-3-carboxylate and its coordination complexes with ethanol, triphenylphosphine oxide, triphenylarsine oxide, diphenylcyclopropenone and quinoline N-oxide exhibited high in vitro cytotoxicity (LC50 values in the range 0.25-3.4 μg/mL) when tested against EBV-DNA positive Raji cells and P-388 leukaemia cells, compared to the standard drug 5-Fluorouracil, which showed LC50 values of 11 and >50 μg/mL, respectively, against these cells. Additional tests performed on the Raji cells incubated with the quinoline N-oxide complex in the presence of the tumour promoters, TPA and sodium butyrate, revealed that the diffused and restricted protein components of the early antigen complex were suppressed relative to the control containing only the promoters, indicating impaired function of the genes involved as transactivators in the early lytic cycle of the EBV. The failure of the restriction enzymes Eco R1 and Hind III to cleave the extracted DNA from such treated cells in contrast to the control, coupled with the amplification of the BMLF-1 gene by the PCR technique which was realised only with the DNA of the control and not of the treated sample, point to a punitive interaction of the organotin with the nuclear DNA of the Raji cells
Ozone in the Pacific tropical troposphere from ozonesonde observations
- Author
- Anne M. Thompson
- Ansari Samad
- Bryan J. Johnson
- Fishman
- Francisco Paredes
- Fujiwara
- Fumio Hasebe
- Gopal Sami
- Gregory
- Harris
- Harris
- Harris
- Hoell
- Holger Vömel
- Humberto Enriquez
- Jaime Cornejo
- Jennifer A. Logan
- Jioji Tabuadravu
- Joyce M. Harris
- Kanatathu Koshy
- Kirchhoff
- Kley
- Kley
- Komhyr
- Mario Agama
- Masato Shiotani
- Matakite Maata
- Merrill
- Olson
- Patrick Simon
- Randriambelo
- Randriambelo
- Richard J. Bendura
- Samuel J. Oltmans
- Singh
- Stoller
- Thompson
- Thompson
- Thompson
- Volker W. J. H. Kirchhoff
- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- 04/02/2004
- Field of study
Ozone vertical profile measurements obtained from ozonesondes flown at Fiji, Samoa, Tahiti, and the Galapagos are used to characterize ozone in the troposphere over the tropical Pacific. There is a significant seasonal variation at each of these sites. At sites in both the eastern and western Pacific, ozone mixing ratios are greatest at almost all levels in the troposphere during the September‐November season and smallest during March‐May. The vertical profile has a relative maximum at all of the sites in the midtroposphere throughout the year (the largest amounts are usually found near the tropopause). This maximum is particularly pronounced during the September‐November season. On average, throughout the troposphere, the Galapagos has larger ozone amounts than the western Pacific sites. A trajectory climatology is used to identify the major flow regimes that are associated with the characteristic ozone behavior at various altitudes and seasons. The enhanced ozone seen in the midtroposphere during September‐November is associated with flow from the continents. In the western Pacific this flow is usually from southern Africa (although 10‐day trajectories do not always reach the continent) but also may come from Australia and Indonesia. In the Galapagos the ozone peak in the midtroposphere is seen in flow from the South American continent and particularly from northern Brazil. High ozone concentrations within potential source regions and flow characteristics associated with the ozone mixing ratio peaks seen in both the western and eastern Pacific suggest that these enhanced ozone mixing ratios result from biomass burning. In the upper troposphere, low ozone amounts are seen with flow that originates in the convective western Pacific
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
- Author
- Abrams Simon
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W A
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Cupitt Jason
- Cutino-moguel Maria-teresa
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- De Silva Thushan
- De Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donnison Phil
- Donohue Chloe
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Dunn Chris
- Dunning Jake
- Durand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Eunice Zhang J
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fegan Christopher
- Filipe Ana Da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W S
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Girvan Michelle
- Gkrania-klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Greenhalf William
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-langham Lara
- Law Andrew
- Law Andrew
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyons Ruth
- Lyttle Mark
- Maclean Alan
- Macmahon Michael
- Macnaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Matthew Ridley P
- Maziere Nicole
- Mccafferty Sarah
- Mccullough Katherine
- Mcdonald Sara
- Mcdonald Sarah
- Mcevoy Laurence
- Mcewen Ruth
- Mclauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Noursadeghi Mahdad
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J M
- Openshaw Peter J M
- Ostermann Marlies
- Otahal Igor
- O’shea Matthew K
- Pais Mark
- Palmarini Massimo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Relph Katharine A
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Roger Thompson A A
- Rose Alistair
- Rousseau Guy
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-shimizu Vanessa
- Saviciute Egle
- Scott Janet T
- Scott-brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Sigfrid Louise
- Siggins Matthew K
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tanianis-hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-carey Darell
- Turtle Lance
- Turtle Lance C W
- Twagira Mary
- Ustianowski Andrew
- Vallotton Nick
- Van Tonder Libby
- Vincent-smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/04/2022
- Field of study
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p
Implementation of corticosteroids in treating COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK:prospective observational cohort study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin WA
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Richard
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donegan Cara
- Donegan Cara
- Donelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gon alo
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis WS
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Griffin Julian
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia YW
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Say
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moonesinghe S Ramani
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Rachel H
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Nguyen-Van-Tam Jonathan S
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- Närhi Fiina
- O'Shea Matthew K
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter JM
- Openshaw Peter JM
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline
- Sarah Sarah
- Saviciute Egle
- Schmid Matthias
- Scott Janet T
- Scott-Brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Shenkin Susan D
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G
- Spencer Rebecca G
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson AA Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance
- Turtle Lance CW
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J Eunice
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
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- Seelarbokus A
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- Sellahewa C
- Selvadurai S
- Sen P
- Seraj SS
- Serry M
- Seth I
- Sethi R
- Shafi A
- Shafiq N
- Shaid M
- Shaman S
- Shang E
- Sharif I
- Sharkey E
- Sharma A
- Sharma E
- Sharma S
- Shaw A
- Shaw C
- Sheik-Ali S
- Sheikh A
- Sheikh S
- Sheikh Z
- Shergill M
- Shergill S
- Sherlock J
- Shields P
- Shingles C
- Shirazi S
- Shurovi BN
- Siddiqui A
- Siddiqui I
- Silke E
- Sim DPY
- Sim R
- Simmonds L
- Simon A
- Simpson L
- Simpson R
- Sinclair E
- Singagireson S
- Singh K
- Singh KKR
- Sinha C
- Sivagnanasithiyar T
- Sivakumar C
- Sivakumar R
- Skulsky S
- Slade G
- Slade RD
- Sleight S
- Small S
- Smallwood J
- Smart B
- Smart G
- Smart YW
- Smith ACD
- Smith C
- Smith F
- Smith H
- Smith J
- Smith M
- Smith R
- Sonagara V
- Song A
- Soonawalla Z
- Soor P
- Spencer R
- Spiers H
- Spoor H
- Springford LR
- Srikanthan M
- Sriram A
- Stageman N
- Standfield N
- Stanger S
- Stanier P
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
- Sureshkumar A
- Suri A
- Svolkinas D
- Swan A
- Swan I
- Swaray A
- Swartbol T
- Symons L
- Szczap A
- Szuman A
- Tailor S
- Tam J
- Tam JP
- Tan CY
- Tan KL
- Tan L
- Tan LC
- Tan S
- Tan TSE
- Tang A
- Tang M
- Tanna A
- Taribagil P
- Tariq A
- Tate S
- Tayeh S
- Taylor K
- Taylor O
- Taylor R
- Taylor Z
- Telfer R
- Teng T
- Tenters F
- Teo R
- Thachettu A
- Thakrar D
- Thatcher A
- Theodoropoulou K
- Thomas A
- Thomas D
- Thomas M
- Thomas O
- Thomas S
- Thompson G
- Thompson J
- Thoms BL
- Thomson F
- Thorley N
- Thorn C
- Thornton T
- Thorpe O
- Tilliridou V
- Titu L
- Tod N
- Toellner H
- Toh C
- Toma T
- Tonks A
- Torrance HD
- Townsend D
- Traish M
- Trenear R
- Tresidder S
- Trevett J
- Triniman MC
- Trotter M
- Tsang JCH
- Tsang K
- Tseu B
- Tsui A
- Tullett A
- Tummon R
- Turlejski T
- Turner J
- Turner S
- Tyson N
- Ubhi HK
- Ujjal S
- Underhill R
- Vadgama N
- Vaidya A
- Vakharia A
- Van Den Berg N
- Van der Laan S
- Van Winsen K
- Vara S
- Varathan Y
- Varatharasasingam K
- Varcada M
- Vaughan R
- Vella-Baldacchino M
- Ventre C
- Venturini S
- Verma N
- Vernet G
- Victor L
- Vig S
- Vine M
- Vipond M
- Virani N
- Vizor R
- Vyas M
- Wadood Q
- Waite K
- Wakeford W
- Walford B
- Walker EY
- Walker G
- Walker K
- Walker L
- Walker NR
- Walls L
- Walsh T
- Wang H
- Wang L
- Wang X
- Ward AE
- Ward J
- Ward N
- Ward T
- Warren L
- Warren O
- Warusavitarne J
- Waterman A
- Waters S
- Watkinson G
- Watson L
- Watson N
- Waugh D
- Wayman J
- Webb E
- Webb R
- Weegenaar C
- Wei R
- Welsh K
- Whewell H
- Whitcroft I
- White C
- White F
- White P
- Whitham R
- Whyte M
- Widdison A
- Wiffen L
- Wigley C
- Wijeyaratne M
- Williams C
- Williams G
- Williams H
- Williams I
- Williams LM
- Williams P
- Williams S
- Wilson H
- Wilson J
- Wilson R
- Wilson V
- Wimalathasan A
- Woin E
- Wong C
- Wong E
- Wong J
- Wong MHY
- Wood CM
- Woodhams K
- Woolley A
- Wootton E
- Worley E
- Worsfold M
- Wright OW
- Wright R
- Wright S
- Wroe N
- Wynell-Mayow W
- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
- Yap J
- Yardimci E
- Yarham E
- Yasin IH
- Yasin T
- Yates J
- Ye W
- Yeo A
- Yeoh T
- Yeung J
- Yin ZD
- Yip J
- Yoganayagam N
- Yogeswara T
- York J
- Yousaf A
- Youssef H
- Yu T
- Yule A
- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Test beam performance of a CBC3-based mini-module for the Phase-2 CMS Outer Tracker before and after neutron irradiation
- Author
- Abbaneo D.
- Abbas M.
- Adam W.
- Agah A.
- Agram J.-L.
- Ahmad A.
- Ahmed I.
- Akpinar A.
- Albergo S.
- Albert E.
- Albrecht A.
- Alexander J.
- Alhusseini M.
- Alibordi M.
- Allard Y.
- Allongue B.
- Ally D.
- Almeida J.
- Anagnostou G.
- Andrea J.
- Androsov K.
- Anguiano J.
- Antonello M.
- Apparu D.
- Ardila L.
- Asenov P.
- Asghar M. I.
- Assiouras P.
- Awais A.
- Awan M. I. M.
- Azzi P.
- Azzurri P.
- Bacchetta N.
- Backhaus M.
- Bagliesi G.
- Bahinipati S.
- Bainbridge R.
- Bakshi A.
- Baldinelli G.
- Balzer M.
- Balázs T.
- Baradia S.
- Barbagli G.
- Bardelli G.
- Barinoff M.
- Bartek R.
- Bartosik N.
- Bartók M.
- Barvich T.
- Basnet A.
- Basti A.
- Batista Lopes J.
- Battacharya R.
- Baulieu G.
- Bean A.
- Beaumont W.
- Beccherle R.
- Becker R.
- Behera P. K.
- Behera S. C.
- Bellan R.
- Benecke A.
- Benelli G.
- Benvenuti D.
- Bergamin G.
- Bergauer T.
- Berger B.
- Berry D. R.
- Bertl W.
- Bevilacqua T.
- Bhardwaj A.
- Bhattacharya S.
- Bianchi F.
- Bianchini L.
- Bilei G. M.
- Bisello D.
- Biskop H.
- Bizzaglia S.
- Blanchot G.
- Blekman F.
- Bloch D.
- Bloom K.
- Boccali T.
- Bonnevaux A.
- Bonnin C.
- Bonomelli G.
- Borg J.
- Bortignon P.
- Bosi F.
- Botta V.
- Boudoul G.
- Boyer F.
- Breugelmans N.
- Brianzi M.
- Bright-Thonney S.
- Brigljević V.
- Brivio F.
- Brom J.-M.
- Brown C.
- Bruner T.
- Bruno G.
- Bruschini D.
- Brücken E.
- Buhmann P.
- Burkett K.
- Bury F.
- Butler D.
- Butz E.
- Bärtschi P.
- Bösiger K.
- Calandri A.
- Calderón A.
- Calligaris L.
- Camaiani B.
- Caminada L.
- Campbell A.
- Canelli F.
- Canepa A.
- Cannaert E.
- Caponetto L.
- Caprai M.
- Caputo C.
- Caratelli A.
- Cardini A.
- Cariola P.
- Carnesecchi R.
- Caselle M.
- Cassese A.
- Castaldi R.
- Ceccarelli R.
- Cerchi S.
- Ceresa D.
- Chabert E.
- Chanon N.
- Charles L.
- Chatterjee S.
- Chawla R.
- Checcucci B.
- Chen P.-H.
- Chen X.
- Cheng C.
- Chertok M.
- Chitroda B.
- Christiansen J.
- Ciangottini D.
- Ciaranfi R.
- Ciocci M. A.
- Ciulli V.
- Civinini C.
- Claes D. R.
- Clement E.
- Clerbaux B.
- Coldham K.
- Cole J.
- Coli S.
- Collard C.
- Connor P.
- Consuegra Rodriguez S.
- Contardo D.
- Conway J.
- Cooperstein S. B.
- Cormier K.
- Costa M.
- Costa S.
- Coubez X.
- Covarelli R.
- Cranshaw D.
- Creanza D.
- Cumalat J. P.
- Cussans D.
- D\u27Alessandro R.
- D\u27Amante V.
- D\u27Angelo P.
- D\u27Hondt J.
- Daguin J.
- Damanakis K.
- Dangelser E.
- Dansana S.
- Darwish M. R.
- Das A. K.
- Das S.
- Dash G.
- Daskalakis G.
- Davis J.
- de Cosa A.
- De Favereau J.
- De Lentdecker G.
- De Moor A.
- de Palma M.
- De Robertis G.
- De Wit A.
- Delaere C.
- Delcourt M.
- Dell\u27Orso R.
- Dellacasa G.
- Demaria N.
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- Publication venue
- Institute of Physics Publishing Ltd
- Publication date
- 05/05/2023
- Field of study
The Large Hadron Collider (LHC) at CERN will undergo major upgrades to increase the instantaneous luminosity up to 5–7.5×1034 cm−2s−1. This High Luminosity upgrade of the LHC (HL-LHC) will deliver a total of 3000–4000 fb-1 of proton-proton collisions at a center-of-mass energy of 13–14 TeV. To cope with these challenging environmental conditions, the strip tracker of the CMS experiment will be upgraded using modules with two closely-spaced silicon sensors to provide information to include tracking in the Level-1 trigger selection. This paper describes the performance, in a test beam experiment, of the first prototype module based on the final version of the CMS Binary Chip front-end ASIC before and after the module was irradiated with neutrons. Results demonstrate that the prototype module satisfies the requirements, providing efficient tracking information, after being irradiated with a total fluence comparable to the one expected through the lifetime of the experiment
Search for invisible decays of the Higgs boson produced via vector boson fusion in proton-proton collisions at s = 13 TeV
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- Yzquierdo A. Pérez-Calero
- Zabi A.
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- Zeinali M.
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- Zghiche A.
- Zhang F.
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- Zhang Y.
- Zhang Z.
- Zhao J.
- Zhizhin I.
- Zhokin A.
- Zhu R. Y.
- Ziemons T.
- Zipper N.
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- Zolkapli Z.
- Zorbakir I. S.
- Zorbilmez C.
- Zotto P.
- Zotz A.
- Zou D.
- Zou R.
- Zucchetta A.
- Zumerle G.
- Zuo X.
- Zuolo D.
- Zygala L.
- Álvarez C. Ramón
- Özçelik Ö.
- Publication venue
- American Physical Society
- Publication date
- 11/07/2022
- Field of study
A search for invisible decays of the Higgs boson produced via vector boson fusion (VBF) has been performed with 101 fb−1 of proton-proton collisions delivered by the LHC at s =13 TeV and collected by the CMS detector in 2017 and 2018. The sensitivity to the VBF production mechanism is enhanced by constructing two analysis categories, one based on missing transverse momentum and a second based on the properties of jets. In addition to control regions with Z and W boson candidate events, a highly populated control region, based on the production of a photon in association with jets, is used to constrain the dominant irreducible background from the invisible decay of a Z boson produced in association with jets. The results of this search are combined with all previous measurements in the VBF topology, based on data collected in 2012 (at s =8 TeV), 2015, and 2016, corresponding to integrated luminosities of 19.7, 2.3, and 36.3 fb−1, respectively. The observed (expected) upper limit on the invisible branching fraction of the Higgs boson is found to be 0.18 (0.10) at the 95% confidence level, assuming the standard model production cross section. The results are also interpreted in the context of Higgs-portal models
Measurement of the B0s → μ+ μ− decay properties and search for the B0 → μ+μ− decay in proton-proton collisions at √s = 13 TeV
- Author
- Aarrestad T. K.
- Aarup Petersen H.
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdullin S.
- Abercrombie D.
- Abreu A.
- Abu Zeid S.
- Acharya H.
- Acosta D.
- Adam W.
- Adamidis K.
- Adams E.
- Adams M. R.
- Adams T.
- Addesa F. M.
- Adloff C.
- Adzic P.
- Afanasiev S.
- Agapitos A.
- Agarwal G.
- Agram J.-L.
- Aguilar-Benitez M.
- Agyel D.
- Ahmad A.
- Ahmad M.
- Ahmed A.
- Aimè C.
- Akchurin N.
- Akgun B.
- Akpinar A.
- Albert A.
- Albrecht A.
- Albrecht S.
- Albrow M.
- Alcaraz Maestre J.
- Alcerro Alcerro L. F.
- Aldaya Martin M.
- Aldá Júnior W. L.
- Aleksandrov A.
- Alexander J.
- Alhusseini M.
- Alimena J.
- Alison J.
- Allmond B.
- Almond J.
- Alpana A.
- Alvarez Gonzalez B.
- Alverson G.
- Alves Gallo Pereira M.
- Alves G. A.
- Aly R.
- Alyari M.
- Amapane N.
- Ambrozas M.
- Amendola C.
- Amin N.
- Amram O.
- Amsler C.
- An S.
- An Y.
- Anagnostou G.
- Andrea J.
- Andreev V.
- Andreev Yu.
- Andrejkovic J. W.
- Andrews M. B.
- Androsov K.
- Anguiano J.
- Antchev G.
- Anthony D.
- Antonello M.
- Antunovic Z.
- Apollinari G.
- Apparu D.
- Appelt E.
- Apresyan A.
- Araujo M.
- Arcaro D.
- Arcidiacono R.
- Argiro S.
- Arneodo M.
- Aruta C.
- Asawatangtrakuldee C.
- Asenov P.
- Asghar M. I.
- Asilar E.
- Askew A.
- Asmuss P.
- Assiouras P.
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- Vats D.
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- Vazzoler F.
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- Publication venue
- North-Holland Publishing
- Publication date
- 20/06/2023
- Field of study
- …