Images in Pathology - Isolated Splenic Metastases Occurring as an Unknown Primary Lesion

A 62-year-old female was referred for evaluation of enlarged spleen on physical examination. Abdominal examination revealed splenomegaly, the liver was not palpable, and rectal examination was unremarkable. Lactate dehydrogenase level was mildly elevated at 557 U/L (normal range, 240 U/L to 480 U/L). Results of other routine biochemical and hematologic tests were within normal ranges. The carcinoembryonic antigen (CEA) level was 19 ng/mL (normal, 0 ng/mL to 3.4 ng/mL)

Isolated splenic metastases occurring as an unknown primary lesion

A 62-year-old female was referred for evaluation of enlarged spleen on physical examination. Abdominal examination revealed splenomegaly, the liver was not palpable, and rectal examination was unremarkable. Lactate dehydrogenase level was mildly elevated at 557 U/L (normal range, 240 U/L to 480 U/L). Results of other routine biochemical and hematologic tests were within normal ranges. The carcinoembryonic antigen (CEA) level was 19 ng/mL (normal, 0 ng/mL to 3.4 ng/mL)

DutchSemCor: Building a semantically annotated corpus for Dutch

State of the art Word Sense Disambiguation (WSD) systems require large sense-tagged corpora along with lexical databases to reach satisfactory results. The number of English language resources for developed WSD increased in the past years, while most other languages are still under-resourced. The situation is no different for Dutch. In order to overcome this data bottleneck, the DutchSemCor project will deliver a Dutch corpus that is sense-tagged with senses from the Cornetto lexical database. Part of this corpus (circa 300K examples) is manually tagged. The remainder is automatically tagged using different WSD systems and validated by human annotators. The project uses existing corpora compiled in other projects; these are extended with Internet examples for word senses that are less frequent and do not (sufficiently) appear in the corpora. We report on the status of the project and the evaluations of the WSD systems with the current training data

Are there Correleations among histologic radiologic and cytopathologic findings in non-allergic Chronic rinosinusitis without nasal polyposis

Purpose: To investigate any correlations among cytopathologic, radiologic, and historic findings in non-allergic chronic rhinosinusitis without nasal polyposis. Materials and Methods: This prospective study was done on 40 adult patients who had undergone functional endoscopic sinus surgery due to chronic rhinosinusitis. Symptom, nasal smear, paranasal computed tomography, as well as histopathologic findings of uncinate process, anterior ethmoid cells, and ethmoidal infundibulum were scored. Correlations were analysed among symptom, radiologic, and cytopathologic scores. Results: While the symptom scores of patients with chronic rhinosinusitis were positively correlated with only nasal smear scores, it was not correlated with computed tomography and histopathologic scores. On the other hand, radiologic scores were correlated with tissue eosinophils scores of uncinate process, anterior ethmoidal cells, and ethmoidal infundibulum Conclusions: The correlation of symptom score to nasal smear score in chronic sinusitis may be an evidence for the positive relationship symptoms and acute inflammation. The correlation of radiologic score to eosinophilia scores of uncinate process, anterior ethmoidal cells, and infundibulum may signify the importance of tissue eosinophils in chronic sinusitis. Keywords: Rhinosinusitits, nasal polyposis, non-allergic rhinosinusitis. Nigerian Journal of Otorhinolaryngology Vol. 3 (2) 2006: pp. 45-5

The effect of gadolinium-based contrast agents on rat testis

Mercantepe, Tolga/0000-0002-8506-1755; INECIKLI, MEHMET FATIH/0000-0002-9796-8223; yilmaz, adnan/0000-0003-4842-1173; TUMKAYA, Levent/0000-0002-2814-5194WOS: 000438889600019PubMed: 29700836Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. the purpose of this prospective animal study was to investigate the effect of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCAs) on rat testis tissue and to compare these molecules in terms of tissue damage. Thirty-two male Sprague-Dawley rats were kept without drugs for 5weeks after administration of 0.1mmol mg(-1) kg(-1) (0.2ml/kg) gadodiamide and gadoteric acid for 4days over 5weeks. Biochemical, histopathological and immunohistochemical changes in testis tissue were evaluated at the end of 10weeks. When used in repeated clinical doses, gadolinium was observed to increase apoptosis in the Leydig cells of the rat testis, and to increase serum Ca+2 levels and reduce testosterone levels (p.05). Both linear and macrocyclic contrast agents have toxic effects on testis tissue, irrespective of the type of drug.Recep Tayyip Erdogan University Scientific Research Projects Coordination UnitRecep Tayyip Erdogan University [TSA-2016-559]We confirm that all of the materials needed for this experimental study was derived from Recep Tayyip Erdogan University Scientific Research Projects Coordination Unit (code: TSA-2016-559)

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

Arslan, Mustafa/0000-0003-4882-5063; AYDIN, Muhammed Enes/0000-0001-8491-6566WOS: 000392564800007PubMed: 28127969BACKGROUNDAND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross-clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-inflammatory drugs (NSAID) for postoperative analgesia. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg iv) and intravenous ibuprofen (30 mg/kg iv) on erythrocyte deformability in I/R model in rats. MATERIALS AND METHODS: Four study groups, each containing 6 Wistar rats were created. Laparotomy was performed in all groups under general anesthesia with ketamine and xylazine. In all groups except sham group, ischemia and reperfusion were achieved by clamping and declamping the infrarenal abdominal aorta for 120 minutes. Rats in Group IR+L received intravenous infusion of lornoxicam (2 mg/kg) while rats in Group 1R+I received intravenous infusion of ibubrofen (30 mg/kg) following 2 hours of ischemic period. At the end of reperfusion period, erythrocyte packs were prepared from heparinized blood samples. Erythrocyte suspensions with hematocrit at a concentration of 5% in a phosphate-buffered saline (PBS) were used in order to perform deformability measurements. The value of p<0.05 was considered statistically significant. RESULTS: Relative resistance has increased in ischemia reperfusion group when compared to control group (p < 0.0001). Lornoxicam or ibuprofen intravenous treatments did not change the erythrocyte deformability during ischemia reperfusion period in rats (p=0.851, p=0.690). CONCLUSION: Intravenous ibuprofen or lornoxicam administrations during ischemia reperfusion period in rats have no negative effect on erythrocyte deformability. The findings of the study should be supported with more detailed and extensive clinical/experimental studies in the future (Fig. 1, Ref. 18). Text in PDF www.elis.sk