Improved force-directed scheduling in high-throughput digital signal processing

This paper discusses improved force-directed scheduling and its application in the design of high-throughput DSP systems, such as real-time video VLSL circuits. We present a mathematical justification of the technique of force-directed scheduling, introduced by Paulin and Knight (1989), and we show how the algorithm can be used to find cost-effective time assignments and resource allocations, allowing trade-offs between processing units and memories. Furthermore, we present modifications that improve the effectiveness and the efficiency of the algorithm. The significance of the improvements is illustrated by an empirical performance analysis based on a number of problem instance

Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice.

We have previously reported that amifostine potentiates the anti-tumour activity of carboplatin in mice. The present study was carried out in well-established human ovarian cancer xenografts OVCAR-3, A2780 and FMa grown subcutaneously in the nude mouse. It was found that a single dose of amifostine resulted in a higher increase in the anti-tumour activity of carboplatin than three doses of amifostine. A single dose of amifostine increased the AUC (area under the curve) values of total platinum in plasma ultrafiltrate (30.1 vs 18.2 microM x h), liver (307.7 vs 236.4 nmol g(-1) x h), kidney (500.8 vs 368.3 nmol g(-1) x h) and OVCAR-3 tumour tissue (184.0 vs 146.8 nmol g(-1) x h). Despite this increase in total platinum, a decrease in platinum (Pt)-DNA adduct levels was observed in liver, kidney and bone marrow, which was significant in liver. In tumour tissue an insignificant increase in Pt-DNA adduct levels, specifically the Pt-GG adduct, was observed after treatment with a single dose of amifostine, which may explain the increase in anti-tumour activity. The increase in the AUC of total platinum was probably caused by a reduction in body temperature, which was most severe after three doses of amifostine. The extreme hypothermia may be the reason that three doses of amifostine resulted in less potentiation of the efficacy of carboplatin

Metastatic gastric cancer presenting with shoulder-hand syndrome: a case report

<p>Abstract</p> <p>Introduction</p> <p>Shoulder-hand syndrome is a relatively rare clinical entity classified as a complex regional pain syndrome type 1 and consisting essentially of a painful 'frozen shoulder' with disability, swelling, vasomotor or dystrophic changes in the homolateral hand. The pathophysiology is not completely clear but a predominant 'sympathetic' factor affecting the neural and vascular supply to the affected parts seems to be involved. Shoulder-hand syndrome has been related to many surgical, orthopedic, neurological and medical conditions; it is more often seen after myocardial infarction, hemiplegia and painful conditions of neck and shoulder, such as trauma, tumors, cervical discogenic or intraforaminal diseases and shoulder calcific tendinopathy, but has also been associated with herpetic infections, brain and lung tumors, thoracoplasty and drugs including phenobarbitone and isoniazid. The diagnosis of shoulder-hand syndrome is primarily clinical, but imaging studies, particularly bone scintigraphy, may be useful to exclude other disorders.</p> <p>Case presentation</p> <p>We report the case of a 67-year-old woman who presented with shoulder-hand syndrome as the initial manifestation of gastric cancer which had metastasized to bone.</p> <p>Conclusion</p> <p>Wider investigations are advisable in patients with atypical shoulder-hand syndrome. To the best of the authors' knowledge this is the first case of shoulder-hand syndrome associated with metastatic gastric cancer.</p

Some commonly unrecognized manifestations of metabolic arthropathies

The metabolic arthropathies are characterized by the deposition of abnormal substances in or around joints. Certain features of some of these arthropathies and their significance have only recently been recognized and others have been insufficiently emphasized. An important group of conditions are the arthropathies related to renal failure and its treatment, namely, aluminum toxicity, periarticular calcification and crystal deposition, hyperparathyroidism, and dialysis-related amyloidosis. Crystal deposition diseases, specifically, gouty arthritis, calcium pyrophosphate deposition, and calcium hydroxyapatite deposition, are also reviewed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30253/1/0000648.pd

Due diligence. Een beschouwing over het due diligence onderzoek volgens het Nederlands recht Den Haag:Boom Juridische Uitgevers ,2009 9789089743923

Contains fulltext : 85599.pdf (publisher's version ) (Open Access)M. Brink Due diligence. Een beschouwing over het due diligence onderzoek volgens het Nederlands recht Den Haag:Boom Juridische Uitgevers ,2009 978908974392

Discovery in het Nederlands Burgerlijk Procesrecht. 'Advies over gegevensverstrekking in burgerrechtelijke zaken' van de Adviescommissie voor Burgerlijk Procesrecht becommentarieerd

Contains fulltext : 77850.pdf (publisher's version ) (Open Access)4 p

Noot bij: HR 23 september 2005, JOR, 2005, 264 (Staatssecretaris van Financiën/ X Holding)

Item does not contain fulltext23 september 200

De curator/ bewindvoerder en het enquêterecht

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