Now I Know the Law : Empowerment of Mining Communities by an Environmental Non-Government Organisation (ENGO)

Environmental non-governmental organizations (ENGOs) became very prominent after the Rio Earth Summit in 1992 as vibrant social movements. Since then, ENGOs operat-ing at the local, regional, or global levels have been instrumental in environmental man-agement in both developed and developing countries. This study sought to investigate the performance of the Wassa Association of Communities Affected by Mining (WACAM), a local ENGO, in some selected mining communities in the Tarkwa-Nsuaem Municipali-ty, in the Western Region of Ghana. Situated in the intepretivist research philosophy, the study employed in-depth interviews, focus group discussions, and observations to collect data from some staff of WACAM, community residents and some government agencies. Purposive and snowball sampling techniques were used to select 77 respondents for the study. Data collected was transcribed and manually coded into themes and categories for analyses. From the perspective of the respondents and participants, the study found that WACAM performed well in mitigating the environmental ills caused to the mining com-munities. WACAM employed the use of advocacy and capacity building as the means to empower poor and vulnerable groups of people and also to influence public decision making and implementation, to challenge the status quo of social injustices, and to defend their human rights. It is recommended that local and/or international donor agencies should sponsor the activities of such ENGOs. Moreover, there should be healthy collabo-ration between WACAM, government agencies, especially the Environmental Protection Agency, and local community residents to sustainably manage the exploitation of natural resources

Drama without drama: The late rise of scripted TV formats

This article revisits the history of TV formats - concepts of TV shows that are licensed for local adaptations – focusing on scripted entertainment. While the TV format revolution of the 1990s bypassed scripted formats, they have been catching up in recent years. This paper analyses both the reasons for this late rise and the factors behind the recent growth. It argues that the adaptation of scripted formats is more complex and risks remain higher than for other genres. The underlying economics of their production and distribution also differs from non-scripted formats. Stars came together when demand for drama increased worldwide, Hollywood studios began to mine their catalogues, new exporters and scripted genres emerged, and knowledge transfer techniques improved. Finally, this paper analyses the significance of the rise of scripted entertainment in the global TV format trading system

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of polysaccharides, nucleic acids and proteins. We hypothesised that carbohydrates could contribute to immune recognition of Pseudomonas aeruginosa biofilms by engaging C-type lectins. Here we show binding of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), mannose receptor (MR, CD206) and Dectin-2 to P. aeruginosa biofilms. We also demonstrate that DC-SIGN, unlike MR and Dectin-2, recognises planktonic P. aeruginosa cultures and this interaction depends on the presence of the common polysaccharide antigen. Within biofilms DC-SIGN, Dectin-2 and MR ligands appear as discrete clusters with dispersed DC-SIGN ligands also found among bacterial aggregates. DC-SIGN, MR and Dectin-2 bind to carbohydrates purified from P. aeruginosa biofilms, particularly the high molecular weight fraction (HMW; >132,000 Da), with KDs in the nM range. These HMW carbohydrates contain 74.9–80.9% mannose, display α-mannan segments, interfere with the endocytic activity of cell-associated DC-SIGN and MR and inhibit Dectin-2-mediated cellular activation. In addition, biofilm carbohydrates reduce the association of the DC-SIGN ligand Lewisx, but not fucose, to human monocyte-derived dendritic cells (moDCs), and alter moDC morphology without affecting early cytokine production in response to lipopolysaccharide or P. aeruginosa cultures. This work identifies the presence of ligands for three important C-type lectins within P. aeruginosa biofilm structures and purified biofilm carbohydrates and highlights the potential for these receptors to impact immunity to P. aeruginosa infection

The global burden of injury: Incidence, mortality, disability-adjusted life years and time trends from the global burden of disease study 2013

Background The Global Burden of Diseases (GBD), Injuries, and Risk Factors study used the disabilityadjusted life year (DALY) to quantify the burden of diseases, injuries, and risk factors. This paper provides an overview of injury estimates from the 2013 update of GBD, with detailed information on incidence, mortality, DALYs and rates of change from 1990 to 2013 for 26 causes of injury, globally, by region and by country. Methods Injury mortality was estimated using the extensive GBD mortality database, corrections for illdefined cause of death and the cause of death ensemble modelling tool. Morbidity estimation was based on inpatient and outpatient data sets, 26 cause-of-injury and 47 nature-of-injury categories, and seven follow-up studies with patient-reported long-term outcome measures. Results In 2013, 973 million (uncertainty interval (UI) 942 to 993) people sustained injuries that warranted some type of healthcare and 4.8 million (UI 4.5 to 5.1) people died from injuries. Between 1990 and 2013 the global age-standardised injury DALY rate decreased by 31% (UI 26% to 35%). The rate of decline in DALY rates was significant for 22 cause-of-injury categories, including all the major injuries. Conclusions Injuries continue to be an important cause of morbidity and mortality in the developed and developing world. The decline in rates for almost all injuries is so prominent that it warrants a general statement that the world is becoming a safer place to live in. However, the patterns vary widely by cause, age, sex, region and time and there are still large improvements that need to be made