Business intelligence gap analysis: a user, supplier and academic perspective

Business intelligence (BI) takes many different forms, as indicated by the varying definitions of BI that can be found in industry and academia. These different definitions help us understand of what BI issues are important to the main players in the field of BI; users, suppliers and academics. The goal of this research is to discover gaps and trends from the standpoints of BI users, BI suppliers and academics, and to examine their effects on business and academia. Consultants also play an important role since they can be seen as the link between users and suppliers. Two research methods are combined to accomplish this goal. We examine the BI focus of users and suppliers through a survey, and we gain insight to the BI focus of academics, vendor-neutral consultants (typical representatives like Forrester, Gartner and IDC) and vendor- specific consultants (typical representatives like IBM, Information builders, Microsoft, Oracle and SAP) through their publications. Previous studies indicate that similar article analyses often focus on academic research methods only. That means that the results so far often reveal the academic perspective. Unlike these previous studies, the perspective of this research is not limited to academics. Our results provide insight of the BI trends and BI issue ranking of BI users, suppliers, academics, vendors neutral consultants and vendor specific consultant

Mismorphism: a Semiotic Model of Computer Security Circumvention (Extended Version)

In real world domains, from healthcare to power to finance, we deploy computer systems intended to streamline and improve the activities of human agents in the corresponding non-cyber worlds. However, talking to actual users (instead of just computer security experts) reveals endemic circumvention of the computer-embedded rules. Good-intentioned users, trying to get their jobs done, systematically work around security and other controls embedded in their IT systems. This paper reports on our work compiling a large corpus of such incidents and developing a model based on semiotic triads to examine security circumvention. This model suggests that mismorphisms---mappings that fail to preserve structure---lie at the heart of circumvention scenarios; differential perceptions and needs explain users\u27 actions. We support this claim with empirical data from the corpus

Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters

Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system

Are care staff equipped for end-of-life communication? : a cross-sectional study in long-term care facilities to identify determinants of self-efficacy

Background: End-of-life conversations are rarely initiated by care staff in long-term care facilities. A possible explanation is care staff's lack of self-efficacy in such conversations. Research into the determinants of self-efficacy for nurses and care assistants in end-of-life communication is scarce and self-efficacy might differ between care staff of mental health facilities, nursing homes, and care homes. This study aimed to explore differences between care staff in mental health facilities, nursing homes, and care homes with regard to knowledge about palliative care, time pressure, and self-efficacy in end-of-life communication, as well as aiming to identify determinants of high self-efficacy in end-of-life communication. Methods: Two cross-sectional Dutch studies, one in mental health facilities and one in nursing and care homes (PACE study). Nurses and care assistants were invited to complete a questionnaire in 2015. Multivariable logistic regression analyses were performed to identify determinants of high self-efficacy. Results: Five hundred forty one nurses and care assistants completed a survey; 137 worked in mental health facilities, 172 in nursing homes, and 232 in care homes. Care staff at mental health facilities were the most knowledgeable about the World Health Organization's definition of palliative care: 76% answered 4-5 out of 5 items correctly compared to 38% of nursing home staff and 40% of care home staff (p 36, female, with formal palliative care training, and knowledge of the palliative care definition. Conclusion: Mental healthcare staff knew more about palliative care and had higher self-efficacy in end-of-life communication compared to nursing and care home staff. Educating care staff about providing palliative care and training them in it might improve end-of-life communication in these facilities

Mitochondrial DNA Manipulations Affect Tau Oligomerization

Background:Mitochondrial dysfunction and tau aggregation occur in Alzheimer’s disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. Objective:To further explore how mitochondria influence tau, we measured tau oligomer levels in human neuronal SH-SY5Y cells with different mitochondrial DNA (mtDNA) manipulations. Methods:Specifically, we analyzed cells undergoing ethidium bromide-induced acute mtDNA depletion, ρ0 cells with chronic mtDNA depletion, and cytoplasmic hybrid (cybrid) cell lines containing mtDNA from AD subjects. Results:We found cytochrome oxidase activity was particularly sensitive to acute mtDNA depletion, evidence of metabolic re-programming in the ρ0 cells, and a relatively reduced mtDNA content in cybrids generated through AD subject mitochondrial transfer. In each case tau oligomer levels increased, and acutely depleted and AD cybrid cells also showed a monomer to oligomer shift. Conclusion:We conclude a cell’s mtDNA affects tau oligomerization. Overlapping tau changes across three mtDNA-manipulated models establishes the reproducibility of the phenomenon, and its presence in AD cybrids supports its AD-relevance

Celestial Mechanics, Conformal Structures, and Gravitational Waves

The equations of motion for $N$ non-relativistic particles attracting according to Newton's law are shown to correspond to the equations for null geodesics in a $(3N+2)$-dimensional Lorentzian, Ricci-flat, spacetime with a covariantly constant null vector. Such a spacetime admits a Bargmann structure and corresponds physically to a generalized pp-wave. Bargmann electromagnetism in five dimensions comprises the two Galilean electro-magnetic theories (Le Bellac and L\'evy-Leblond). At the quantum level, the $N$-body Schr\"odinger equation retains the form of a massless wave equation. We exploit the conformal symmetries of such spacetimes to discuss some properties of the Newtonian $N$-body problem: homographic solutions, the virial theorem, Kepler's third law, the Lagrange-Laplace-Runge-Lenz vector arising from three conformal Killing 2-tensors, and motions under inverse square law forces with a gravitational constant $G(t)$ varying inversely as time (Dirac). The latter problem is reduced to one with time independent forces for a rescaled position vector and a new time variable; this transformation (Vinti and Lynden-Bell) arises from a conformal transformation preserving the Ricci-flatness (Brinkmann). A Ricci-flat metric representing $N$ non-relativistic gravitational dyons is also pointed out. Our results for general time-dependent $G(t)$ are applicable to the motion of point particles in an expanding universe. Finally we extend these results to the quantum regime.Comment: 26 pages, LaTe

Combining cytotoxicity assessment and Xenopus laevis phenotypic abnormality assay as a predictor of nanomaterial safety

The African clawed frog, Xenopus laevis, has been used as an efficient pre-clinical screening tool to predict drug safety during the early stages of the drug discovery process. X. laevis is a relatively inexpensive model that can be used in whole organism high-throughput assays whilst maintaining a high degree of homology to the higher vertebrate models often used in scientific research. Despite an ever-increasing volume of biomedical nanoparticles (NPs) in development, their unique physico-chemical properties challenge the use of standard toxicology assays. Here, we present a protocol that directly compares the sensitivity of X. laevis development as a tool to assess potential NP toxicity by observation of embryo phenotypic abnormalities/lethality after NP exposure to in vitro cytotoxicity obtained using mammalian cell lines. In combination with conventional cytotoxicity assays, the X. laevis phenotypic assay provides accurate data to efficiently assess the safety of a novel biomedical NP

Using nurses and office staff to report prescribing errors in primary care

Objective. To implement a prescribing-error reporting system in primary care offices and analyze the reports. Design. Descriptive analysis of a voluntary prescribing-error-reporting system Setting. Seven primary care offices in Vermont, USA. Participants. One hundred and three prescribers, managers, nurses and office staff. Intervention. Nurses and office staff were asked to report all communications with community pharmacists regarding prescription problems

Interprofessional Education: An evaluation of a joint learning workshop for podiatry and pharmacy students

"Interprofessional Education occurs when two or more professionals learn with, from and about each other to improve collaboration and the quality of care" (CAIPE 2002). Interprofessional education forms part of the Standards for the Initial Education and Training of Pharmacists. Working with and understanding the role of another profession has been shown to positively impact on the quality of care of the patient. Following positive pharmacy student feedback from visits to podiatry clinics an interprofessional learning workshop with case - based scenarios was developed. These were based on patients with high risk medical conditions that would impact on the work of both professions. Data from the feedback forms was evaluated and analysed to determine whether the workshop increased knowledge of the British National Formulary (BNF), the prescribing process and gave an insight in to the role of other healthcare professionals. We discuss how the student’s learning has been enhanced by the contribution of another professional group. The workshop was positively received. Students were observed working together discussing the patients’ conditions and issues relating to their care. This initially revolved around the students’ area of knowledge; however, as the session progressed it became apparent that the students were learning with, from and about each other for the benefit of patient care