New Surgical Treatment for Severe Limb Ischemia

Revascularization after prolonged complete limb ischemia may result in severe damage to skeletal muscle and systemic alterations (postischemic syndrome)

Controlled limb reperfusion as a new surgical technique to reduce postischemic syndrome

In cardiac surgical practice, acute limb ischemia may occur as a result of the insertion of an intraaortic balloon pump, emboli, dissections, and other complications

Surgical revascularization in patients with acute myocardial infarction

This retrospective study was done to access the results of emergency revascularization in patients with acute myocardial infarction

Changing patterns of patients undergoing emergency surgical revascularization for acute coronary occlusion

Between 1977 and 1992 a total of 163 consecutive patients underwent emergency coronary artery bypass grafting after acute coronary occlusion

Controlled limb reperfusion in patients having cardiac operations

In cardiac surgical practice, acute limb ischemia may occur as a result of the insertion of an intraaortic balloon pump, emboli, dissections, and other complications

Investigations on the new free radical scavenger polynitroxyl-albumin to prevent ischemia and reperfusion injury after orthotopic heart transplantation in the pig model

Objective: Nitroxides have strong antioxidant capacity but their effectiveness is limited by their rapid intracellular inactivation. Poly nitroxyl-Albumin (PNA) is capable of regenerating inactivated nitroxide. We tested the effect of PNA against reperfusion injury in heart transplantation. Methods: Pig hearts were transplanted orthotopically. In the control group (n = 9) reperfusion was performed without reperfusion modifications. In the experimental group (n = 10) 1 ml/kg PNA was given before cross-clamp release. Results: Hemodynamic performance was impaired after transplantation in both groups without significant intergroup differences. Plasma malonedialdehyde levels were significantly diminished in the PNA group as compared to the controls. CK-MB levels in both groups were increased within the first 2 h of reperfusion without significant intergroup differences. In contrast, there were found significant higher values of myocardial specific lactate dehydrogenase (LD1) in the controls versus PNA group. Conclusions: PNA was able to reduce lipid peroxidation and attenuate free radical activity. Contractile dysfunction could no be improved, indicating that (a) the radical scavenging effect was to weak or (b) other mechanisms than free oxygen radicals are responsible for myocardial damage in this experimental model. (C) 2001 Elsevier B.V. B.V. All rights reserved