The Separation of Facts and Values

Dr. Kantrowitz maintains that much modern pessimism derives from failure to separate what is from what ought to be and urges that scientific conflicts be resolved as value neutrally as possible

Elitism vs. Checks and Balances in Communicating Scientific Information to the Public

The father of the Science Court describes his objective in proposing the institution as it has come to be known, his efforts to get a major public test of the concept, and insights gained since the initial proposal was made in 1967

Laser propulsion to earth orbit. Has its time come?

Recent developments in high energy lasers, adaptive optics, and atmospheric transmission bring laser propulsion much closer to realization. Proposed here is a reference vehicle for study which consists of payload and solid propellant (e.g. ice). A suitable laser pulse is proposed for using a Laser Supported Detonation wave to produce thrust efficiently. It seems likely that a minimum system (10 Mw CO2 laser and 10 m dia. mirror) could be constructed for about $150 M. This minimum system could launch payloads of about 13 kg to a 400 km orbit every 10 minutes. The annual launch capability would be about 683 tons times the duty factor. Laser propulsion would be an order of magnitude cheaper than chemical rockets if the duty factor was 20 percent (10,000 launches/yr). Launches beyond that would be even cheaper. The chief problem which needs to be addressed before these possibilities could be realized is the design of a propellant to turn laser energy into thrust efficiently and to withstand the launch environment

The Other Thirteenth Amendment: Free African Americans and the Constitution That Wasn\u27t

Non

The Other Thirteenth Amendment: Free African Americans and the Constitution That Wasn\u27t

Non

Cwbr Author Interview: More Than Freedom: Fighting For Black Citizenship In A White Republic 1829-1889

Interview with Stephen Kantrowitz, Professor of History and Director of Graduate Studies at the University of Wisconsin, and recently named a finalist for the Gilder Lehrman Douglass Prize Interviewed by Michael Frawley Civil War Book Review (CWBR): Today the Civil War Book Review is proud to speak with Stephen Kantrowitz, Professor of History and Director of Graduate Studies at the University of Wisconsin. We will be discussing his recent book More than Freedom: Fighting for Black Citizenship in a White Republic 1829-1889. Thank you for joining us today. Stephen Kantrowitz (SK): I am really happy to be with you

The Financial Value of a Higher Education

Five years have passed since the U.S. Census Bureau published synthetic estimates of work-life earnings by educational attainment. This paper updates those figures with the most recent data from the U.S. Census Bureau\u27s annual Current Population Surveys, and adds net present value analysis of the financial benefit of a college degree to the individual and to the federal government. The added value of a bachelor\u27s degree over a high school diploma or GED has increased to $1.2 million in 2005 from$910,000 in 1997-1999. Compared with the average out-of-pocket costs of a college education, this represents a return on investment in excess of 27%. The added value also corresponds to an additional $133,000 in cumulative federal income tax revenue. Accordingly, it would be financially worthwhile for the federal government to replace loans with grants in the financial aid packages of low income students if this yielded at least a 32% increase in the number of low income students graduating with bachelor\u27s degrees

Stability of Castering Wheels for Aircraft Landing Gears, Special Report

In many installations of castering rubber-tired wheels there is a tendency for the wheel to oscillate violently about the spindle axis. This phenomenon, popularly called 'shimmy,' has occurred in some airplane tail wheels and has been corrected in two ways: first by the application of friction in the spindles of the tail wheels; and, second, by locking the wheels while taxiing at high speeds. Shimmy is common with the large wheels used as nose wheels in tricycle landing gears and, since it is impossible to lock the wheels, friction in the nose-wheel spindle has been the sole means of correction. Because the nose wheel is larger than the conventional tail wheel and usually carries a greater load, the larger amounts of spindle friction necessary to prevent shimmy are objectionable. the present paper presents a theoretical and experimental study of the problem of the stability of castering wheels for airplane landing gears. On the basis of simplified assumptions induced from experimental observations, a theoretical study has been made of the shimmy of castering wheels. The theory is based on the discovery of a phenomenon called 'kinematic shimmy' and is compared quantitatively with the results of model experiments. Experimental checks, using a model having low-pressure tires, are reported and the applicability of the results to full scale is discussed. Theoretical methods of estimating the spindle viscous damping and spindle solid friction necessary to avoid shimmy - lateral freedom - is introduced

Transcriptomic alterations underlying pathogenesis and carcinogenesis in COPD

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is a risk factor for lung cancer development. COPD encompasses both emphysema and chronic bronchitis, the pathogenesis of which are unclear. In this dissertation, I leveraged genome-wide gene-expression studies of emphysema and lung cancer to investigate pathogenesis and carcinogenesis in COPD. Tobacco smoke is the primary cause of emphysema. The most severe form is also associated with alpha1-antitrypsin deficiency (AATD) resulting from a mutation. In this study, I leveraged multiple lung samples from patients with emphysema, with or without AATD. While genes involved in tissue repair decreased with emphysema severity, the unfolded protein response (UPR) was uniquely changed in AATD lungs. AATD may play multiple roles in emphysema and UPR activation suggests AAT replacement therapy may be insufficient to treat this form of emphysema. Emphysema is a progressive disease, and the mean linear intercept (Lm) can serve as a surrogate of progression. I evaluated whether Lm increases in non-diseased lungs may represent similar processes to those occurring in emphysema, and could offer insight into early stages of disease or homeostasis. Genes involved in tissue repair increased with Lm in controls but decreased in disease. Tissue repair processes may be active in even the non-insulted lung, suggesting their activity is necessary for lung homeostasis and their deficiency may drive emphysema progression. Finally, COPD patients are at increased lung cancer risk, and transcriptomic changes common to both diseases could explain this risk. In both COPD and lung cancer, I discovered that H3K27Me3 regulated genes are repressed, and that the methyltransferase responsible for H3K27me3, EZH2, is induced. H3K27Me3, an oncogenic histone modification, may drive carcinogenesis and pathogenesis in COPD. Though usual and AATD emphysema share transcriptomic signatures associated with tissue repair, which may be active in the normal homeostatic lung, the UPR changes in AATD emphysema only; successful therapeutic strategies in emphysema will need to account for this difference. In COPD, H3K27Me3 may play a role in both pathogenesis and carcinogenesis, making it an attractive target for therapeutic interventions, but one that would need further augmentation in AATD.2019-11-01T00:00:00