Epidemiology of orbital fractures in a large hospital in the Netherlands: results of implementation of a multidisciplinary orbital trauma team

Introduction:This study aims to describe the epidemiology, aetiology and therapy of orbital fractures in a large municipal hospital in The Hague, Netherlands, and to demonstrate the effectiveness of an integrated approach of orbital trauma care with a team consisting of an ophthalmologist, an orthoptist and an oral and maxillofacial (OMF) surgeon.Methods:We obtained data from patients with an orbital fracture between June 2015 until July 2018. Primary outcomes were the classification of orbital fractures and treatment (conservative or surgical).Results:182 patients were included in this study. The most common type of orbital fracture was an isolated orbital floor fracture (n=56, 30.8%). In most cases, therapy was conservative (69.2%). When surgical repair was indicated, a polydioxanone (PDS) plate was most commonly used (11.5%). The main cause of an orbital fracture was a fall accident (38.5%), followed by assault (32.4%). 32.4% of the patients were intoxicated with alcohol.Conclusion:In our study population, almost 70% (69.2%) of the patients were treated conservatively in our study. Compared to the international literature, this percentage is considerably higher than in other studies. In our opinion, our integrated approach to orbital trauma has led to a justifiable reduction of the proportion of cases receiving surgical intervention in orbital fractures. We would like to advocate the implementation of a similar team in other hospitals to improve the quality and cost-effectiveness of treatment in patients with orbital fractures.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Repurposing a chemosensory macromolecular machine

How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost

Repurposing a chemosensory macromolecular machine

Microbial Biotechnolog

Electron Cryotomography of Bacterial Secretion Systems

In biology, function arises from form. For bacterial secretion systems, which often span two membranes, avidly bind to the cell wall, and contain hundreds of individual proteins, studying form is a daunting task, made possible by electron cryotomography (ECT). ECT is the highest-resolution imaging technique currently available to visualize unique objects inside cells, providing a three-dimensional view of the shapes and locations of large macromolecular complexes in their native environment. Over the past 15 years, ECT has contributed to the study of bacterial secretion systems in two main ways: by revealing intact forms for the first time and by mapping components into these forms. Here we highlight some of these contributions, revealing structural convergence in type II secretion systems, structural divergence in type III secretion systems, unexpected structures in type IV secretion systems, and unexpected mechanisms in types V and VI secretion systems. Together, they offer a glimpse into a world of fantastic forms—nanoscale rotors, needles, pumps, and dart guns—much of which remains to be explored

Repurposing a chemosensory macromolecular machine

How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost

50 Jahre Ostfalia – Von der Fachhochschule zur Hochschule für angewandte Wissenschaften

In Form einer nach Dekaden gegliederten Jubiläumschronik wird die Entwicklung der „Fachhochschule Braunschweig/Wolfenbüttel“ zur „Ostfalia Hochschule für angewandte Wissenschaften“ dargestellt. Beginnend mit den Studierendenunruhen im Jahr 1968 über die Gründung der Fachhochschule im Jahr 1971 wird zunächst der fortschreitende Ausbau der praxisorientierten akademischen Berufsausbildung, insbesondere die Ausweitung auf neue Berufsfelder - als Folge des allgemein wachsenden Bedarfs an akademisch qualifiziertem Personal einerseits sowie der steigenden Zahl von Studienberechtigten andererseits - thematisiert. Diese Entwicklung hatte die Einrichtung neuer Standorte, zahlreicher neuer Studiengänge und Fakultäten ab 1987 zur Folge; auch neue Aufgabengebiete und dementsprechend weitere hochschuleigene Einrichtungen kamen von nun an hinzu. Ab Mitte der 1990er Jahre erfolgten weitere Modernisierungs- und Professionalisierungsschritte, die dann 2008/2010 etwa zur Umbenennung in „Hochschule“ sowie zur Umwandlung der Fachbereiche in Fakultäten führten. Die angewandte Forschung und Entwicklung sowie der Wissens- und Technologietransfer gewannen zunehmend an Bedeutung. Seit den 2000er Jahren wird auch die Etablierung einer Gründungskultur an der Hochschule thematisiert und unterstützt. 2009 erfolgte die Einführung der Dachmarke „Ostfalia Hochschule für angewandte Wissenschaften“ für die vier Standorte. Eine besondere Herausforderung war die Bologna-Reform, die Umstellung der Studiengänge auf die Abschlüsse „Bachelor““ und „Master“. Auch wurden neue Studienwege eingerichtet, um weitere Zielgruppen für ein Studium zu erreichen, etwa das „Studium im Praxisverbund“, das Fern- und das Online-Studium. Aktuelle Themen sind die Verstärkung von inter- und transdisziplinären Projekten in Lehre und Forschung und die „Third Mission“, d.h. die Aktivitäten der Hochschule in den Bereichen Wissens- und Technologietransfer, Weiterbildung und Gesellschaftliches Engagement. Mit einem Nachwort der Präsidentin der Hochschule, Prof. Dr. Rosemarie Karger

De concentratie van kaliumchloride, uitgaande van sylviniet

Document(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science